The role of lncRNA-mediated pyroptosis in cardiovascular diseases

Cardiovascular disease (CVD) is the leading cause of death worldwide. Pyroptosis is a unique kind of programmed cell death that varies from apoptosis and necrosis morphologically, mechanistically, and pathophysiologically. Long non-coding RNAs (LncRNAs) are thought to be promising biomarkers and the...

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Main Authors: Bo Hu, Wen Chen, Yancheng Zhong, Qinhui Tuo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1217985/full
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author Bo Hu
Wen Chen
Yancheng Zhong
Qinhui Tuo
author_facet Bo Hu
Wen Chen
Yancheng Zhong
Qinhui Tuo
author_sort Bo Hu
collection DOAJ
description Cardiovascular disease (CVD) is the leading cause of death worldwide. Pyroptosis is a unique kind of programmed cell death that varies from apoptosis and necrosis morphologically, mechanistically, and pathophysiologically. Long non-coding RNAs (LncRNAs) are thought to be promising biomarkers and therapeutic targets for the diagnosis and treatment of a variety of diseases, including cardiovascular disease. Recent research has demonstrated that lncRNA-mediated pyroptosis has significance in CVD and that pyroptosis-related lncRNAs may be potential targets for the prevention and treatment of specific CVDs such as diabetic cardiomyopathy (DCM), atherosclerosis (AS), and myocardial infarction (MI). In this paper, we collected previous research on lncRNA-mediated pyroptosis and investigated its pathophysiological significance in several cardiovascular illnesses. Interestingly, certain cardiovascular disease models and therapeutic medications are also under the control of lncRNa-mediated pyroptosis regulation, which may aid in the identification of new diagnostic and therapy targets. The discovery of pyroptosis-related lncRNAs is critical for understanding the etiology of CVD and may lead to novel targets and strategies for prevention and therapy.
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spelling doaj.art-0f9df3d7ee20404ea10c061bce78eff42023-06-16T06:11:17ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-06-011010.3389/fcvm.2023.12179851217985The role of lncRNA-mediated pyroptosis in cardiovascular diseasesBo HuWen ChenYancheng ZhongQinhui TuoCardiovascular disease (CVD) is the leading cause of death worldwide. Pyroptosis is a unique kind of programmed cell death that varies from apoptosis and necrosis morphologically, mechanistically, and pathophysiologically. Long non-coding RNAs (LncRNAs) are thought to be promising biomarkers and therapeutic targets for the diagnosis and treatment of a variety of diseases, including cardiovascular disease. Recent research has demonstrated that lncRNA-mediated pyroptosis has significance in CVD and that pyroptosis-related lncRNAs may be potential targets for the prevention and treatment of specific CVDs such as diabetic cardiomyopathy (DCM), atherosclerosis (AS), and myocardial infarction (MI). In this paper, we collected previous research on lncRNA-mediated pyroptosis and investigated its pathophysiological significance in several cardiovascular illnesses. Interestingly, certain cardiovascular disease models and therapeutic medications are also under the control of lncRNa-mediated pyroptosis regulation, which may aid in the identification of new diagnostic and therapy targets. The discovery of pyroptosis-related lncRNAs is critical for understanding the etiology of CVD and may lead to novel targets and strategies for prevention and therapy.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1217985/fullcardiovascular disease (CVD)LncRNA – long noncoding RNAgasdermins (GSDMs)pyroptosisinflammatory
spellingShingle Bo Hu
Wen Chen
Yancheng Zhong
Qinhui Tuo
The role of lncRNA-mediated pyroptosis in cardiovascular diseases
Frontiers in Cardiovascular Medicine
cardiovascular disease (CVD)
LncRNA – long noncoding RNA
gasdermins (GSDMs)
pyroptosis
inflammatory
title The role of lncRNA-mediated pyroptosis in cardiovascular diseases
title_full The role of lncRNA-mediated pyroptosis in cardiovascular diseases
title_fullStr The role of lncRNA-mediated pyroptosis in cardiovascular diseases
title_full_unstemmed The role of lncRNA-mediated pyroptosis in cardiovascular diseases
title_short The role of lncRNA-mediated pyroptosis in cardiovascular diseases
title_sort role of lncrna mediated pyroptosis in cardiovascular diseases
topic cardiovascular disease (CVD)
LncRNA – long noncoding RNA
gasdermins (GSDMs)
pyroptosis
inflammatory
url https://www.frontiersin.org/articles/10.3389/fcvm.2023.1217985/full
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