Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design
As a kind of nature-derived bioactive materials, polyphenol-based hydrogels possess many unique and outstanding properties such as adhesion, toughness, and self-healing due to their specific crosslinking structures, which have been widely used in biomedical fields including wound healing, antitumor,...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-11-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X22000469 |
| _version_ | 1797203683091415040 |
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| author | Zimu Li Zhidong Chen Hongzhong Chen Kebing Chen Wei Tao Xiao-kun Ouyang Lin Mei Xiaowei Zeng |
| author_facet | Zimu Li Zhidong Chen Hongzhong Chen Kebing Chen Wei Tao Xiao-kun Ouyang Lin Mei Xiaowei Zeng |
| author_sort | Zimu Li |
| collection | DOAJ |
| description | As a kind of nature-derived bioactive materials, polyphenol-based hydrogels possess many unique and outstanding properties such as adhesion, toughness, and self-healing due to their specific crosslinking structures, which have been widely used in biomedical fields including wound healing, antitumor, treatment of motor system injury, digestive system disease, oculopathy, and bioelectronics. In this review, starting with the classification of common polyphenol-based hydrogels, the pyramid evolution process of polyphenol-based hydrogels from crosslinking structures to derived properties and then to biomedical applications is elaborated, as well as the efficient reverse design considerations of polyphenol-based hydrogel systems are proposed. Finally, the existing problems and development prospects of these hydrogel materials are discussed. It is hoped that the unique perspective of the review can promote further innovation and breakthroughs of polyphenol-based hydrogels in the future. |
| first_indexed | 2024-04-24T08:23:13Z |
| format | Article |
| id | doaj.art-0f9e2cad1ed246dcab93da58a08401a6 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:23:13Z |
| publishDate | 2022-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-0f9e2cad1ed246dcab93da58a08401a62024-04-16T23:37:25ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2022-11-01174970Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse designZimu Li0Zhidong Chen1Hongzhong Chen2Kebing Chen3Wei Tao4Xiao-kun Ouyang5Lin Mei6Xiaowei Zeng7Institute of Pharmaceutics, School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, ChinaInstitute of Pharmaceutics, School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, ChinaInstitute of Pharmaceutics, School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, ChinaDepartment of Spine Surgery, Center for Orthopaedic Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China; Corresponding author.Center for Nanomedicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, United StatesSchool of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, 316022, ChinaInstitute of Pharmaceutics, School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, ChinaInstitute of Pharmaceutics, School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, China; Corresponding author.As a kind of nature-derived bioactive materials, polyphenol-based hydrogels possess many unique and outstanding properties such as adhesion, toughness, and self-healing due to their specific crosslinking structures, which have been widely used in biomedical fields including wound healing, antitumor, treatment of motor system injury, digestive system disease, oculopathy, and bioelectronics. In this review, starting with the classification of common polyphenol-based hydrogels, the pyramid evolution process of polyphenol-based hydrogels from crosslinking structures to derived properties and then to biomedical applications is elaborated, as well as the efficient reverse design considerations of polyphenol-based hydrogel systems are proposed. Finally, the existing problems and development prospects of these hydrogel materials are discussed. It is hoped that the unique perspective of the review can promote further innovation and breakthroughs of polyphenol-based hydrogels in the future.http://www.sciencedirect.com/science/article/pii/S2452199X22000469BiomaterialsAdhesive hydrogelsPolyphenolDisease treatmentReverse design |
| spellingShingle | Zimu Li Zhidong Chen Hongzhong Chen Kebing Chen Wei Tao Xiao-kun Ouyang Lin Mei Xiaowei Zeng Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design Bioactive Materials Biomaterials Adhesive hydrogels Polyphenol Disease treatment Reverse design |
| title | Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design |
| title_full | Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design |
| title_fullStr | Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design |
| title_full_unstemmed | Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design |
| title_short | Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design |
| title_sort | polyphenol based hydrogels pyramid evolution from crosslinked structures to biomedical applications and the reverse design |
| topic | Biomaterials Adhesive hydrogels Polyphenol Disease treatment Reverse design |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X22000469 |
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