Gravitational Experimental Platform for Animal Models, a New Platform at ESA’s Terrestrial Facilities to Study the Effects of Micro- and Hypergravity on Aquatic and Rodent Animal Models
Using rotors to expose animals to different levels of hypergravity is an efficient means of understanding how altered gravity affects physiological functions, interactions between physiological systems and animal development. Furthermore, rotors can be used to prepare space experiments, e.g., conduc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/6/2961 |
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| author | Julie Bonnefoy Stéphanie Ghislin Jérôme Beyrend Florence Coste Gaetano Calcagno Isabelle Lartaud Guillemette Gauquelin-Koch Sylvain Poussier Jean-Pol Frippiat |
| author_facet | Julie Bonnefoy Stéphanie Ghislin Jérôme Beyrend Florence Coste Gaetano Calcagno Isabelle Lartaud Guillemette Gauquelin-Koch Sylvain Poussier Jean-Pol Frippiat |
| author_sort | Julie Bonnefoy |
| collection | DOAJ |
| description | Using rotors to expose animals to different levels of hypergravity is an efficient means of understanding how altered gravity affects physiological functions, interactions between physiological systems and animal development. Furthermore, rotors can be used to prepare space experiments, e.g., conducting hypergravity experiments to demonstrate the feasibility of a study before its implementation and to complement inflight experiments by comparing the effects of micro- and hypergravity. In this paper, we present a new platform called the Gravitational Experimental Platform for Animal Models (GEPAM), which has been part of European Space Agency (ESA)’s portfolio of ground-based facilities since 2020, to study the effects of altered gravity on aquatic animal models (amphibian embryos/tadpoles) and mice. This platform comprises rotors for hypergravity exposure (three aquatic rotors and one rodent rotor) and models to simulate microgravity (cages for mouse hindlimb unloading and a random positioning machine (RPM)). Four species of amphibians can be used at present. All murine strains can be used and are maintained in a specific pathogen-free area. This platform is surrounded by numerous facilities for sample preparation and analysis using state-of-the-art techniques. Finally, we illustrate how GEPAM can contribute to the understanding of molecular and cellular mechanisms and the identification of countermeasures. |
| first_indexed | 2024-03-10T13:14:09Z |
| format | Article |
| id | doaj.art-0f9f0bacff4647b79d2f24d35a3f6bf8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:14:09Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0f9f0bacff4647b79d2f24d35a3f6bf82023-11-21T10:30:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01226296110.3390/ijms22062961Gravitational Experimental Platform for Animal Models, a New Platform at ESA’s Terrestrial Facilities to Study the Effects of Micro- and Hypergravity on Aquatic and Rodent Animal ModelsJulie Bonnefoy0Stéphanie Ghislin1Jérôme Beyrend2Florence Coste3Gaetano Calcagno4Isabelle Lartaud5Guillemette Gauquelin-Koch6Sylvain Poussier7Jean-Pol Frippiat8Stress, Immunity, Pathogens Laboratory, SIMPA, Université de Lorraine, F-54000 Nancy, FranceStress, Immunity, Pathogens Laboratory, SIMPA, Université de Lorraine, F-54000 Nancy, FranceAnimalerie du Campus Biologie Santé, ACBS, Université de Lorraine, F-54000 Nancy, FranceStress, Immunity, Pathogens Laboratory, SIMPA, Université de Lorraine, F-54000 Nancy, FranceStress, Immunity, Pathogens Laboratory, SIMPA, Université de Lorraine, F-54000 Nancy, FranceAnimalerie du Campus Biologie Santé, ACBS, Université de Lorraine, F-54000 Nancy, FranceLife Sciences in Microgravity, French National Space Agency, CNES, F-75001 Paris, FranceAnimalerie du Campus Biologie Santé, ACBS, Université de Lorraine, F-54000 Nancy, FranceStress, Immunity, Pathogens Laboratory, SIMPA, Université de Lorraine, F-54000 Nancy, FranceUsing rotors to expose animals to different levels of hypergravity is an efficient means of understanding how altered gravity affects physiological functions, interactions between physiological systems and animal development. Furthermore, rotors can be used to prepare space experiments, e.g., conducting hypergravity experiments to demonstrate the feasibility of a study before its implementation and to complement inflight experiments by comparing the effects of micro- and hypergravity. In this paper, we present a new platform called the Gravitational Experimental Platform for Animal Models (GEPAM), which has been part of European Space Agency (ESA)’s portfolio of ground-based facilities since 2020, to study the effects of altered gravity on aquatic animal models (amphibian embryos/tadpoles) and mice. This platform comprises rotors for hypergravity exposure (three aquatic rotors and one rodent rotor) and models to simulate microgravity (cages for mouse hindlimb unloading and a random positioning machine (RPM)). Four species of amphibians can be used at present. All murine strains can be used and are maintained in a specific pathogen-free area. This platform is surrounded by numerous facilities for sample preparation and analysis using state-of-the-art techniques. Finally, we illustrate how GEPAM can contribute to the understanding of molecular and cellular mechanisms and the identification of countermeasures.https://www.mdpi.com/1422-0067/22/6/2961gravityspaceflightdevelopmentadaptationamphibianmice |
| spellingShingle | Julie Bonnefoy Stéphanie Ghislin Jérôme Beyrend Florence Coste Gaetano Calcagno Isabelle Lartaud Guillemette Gauquelin-Koch Sylvain Poussier Jean-Pol Frippiat Gravitational Experimental Platform for Animal Models, a New Platform at ESA’s Terrestrial Facilities to Study the Effects of Micro- and Hypergravity on Aquatic and Rodent Animal Models International Journal of Molecular Sciences gravity spaceflight development adaptation amphibian mice |
| title | Gravitational Experimental Platform for Animal Models, a New Platform at ESA’s Terrestrial Facilities to Study the Effects of Micro- and Hypergravity on Aquatic and Rodent Animal Models |
| title_full | Gravitational Experimental Platform for Animal Models, a New Platform at ESA’s Terrestrial Facilities to Study the Effects of Micro- and Hypergravity on Aquatic and Rodent Animal Models |
| title_fullStr | Gravitational Experimental Platform for Animal Models, a New Platform at ESA’s Terrestrial Facilities to Study the Effects of Micro- and Hypergravity on Aquatic and Rodent Animal Models |
| title_full_unstemmed | Gravitational Experimental Platform for Animal Models, a New Platform at ESA’s Terrestrial Facilities to Study the Effects of Micro- and Hypergravity on Aquatic and Rodent Animal Models |
| title_short | Gravitational Experimental Platform for Animal Models, a New Platform at ESA’s Terrestrial Facilities to Study the Effects of Micro- and Hypergravity on Aquatic and Rodent Animal Models |
| title_sort | gravitational experimental platform for animal models a new platform at esa s terrestrial facilities to study the effects of micro and hypergravity on aquatic and rodent animal models |
| topic | gravity spaceflight development adaptation amphibian mice |
| url | https://www.mdpi.com/1422-0067/22/6/2961 |
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