Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s
Molecular identification was, at last, successfully accomplished for three types of anion channels that are all implicated in cell volume regulation/dysregulation. LRRC8A plus LRRC8C/D/E, SLCO2A1, and TMEM206 were shown to be the core or pore-forming molecules of the volume-sensitive outwardly recti...
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.805148/full |
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| author | Yasunobu Okada Yasunobu Okada Yasunobu Okada Yasunobu Okada Ravshan Z. Sabirov Petr G. Merzlyak Tomohiro Numata Kaori Sato-Numata Kaori Sato-Numata |
| author_facet | Yasunobu Okada Yasunobu Okada Yasunobu Okada Yasunobu Okada Ravshan Z. Sabirov Petr G. Merzlyak Tomohiro Numata Kaori Sato-Numata Kaori Sato-Numata |
| author_sort | Yasunobu Okada |
| collection | DOAJ |
| description | Molecular identification was, at last, successfully accomplished for three types of anion channels that are all implicated in cell volume regulation/dysregulation. LRRC8A plus LRRC8C/D/E, SLCO2A1, and TMEM206 were shown to be the core or pore-forming molecules of the volume-sensitive outwardly rectifying anion channel (VSOR) also called the volume-regulated anion channel (VRAC), the large-conductance maxi-anion channel (Maxi-Cl), and the acid-sensitive outwardly rectifying anion channel (ASOR) also called the proton-activated anion channel (PAC) in 2014, 2017, and 2019, respectively. More recently in 2020 and 2021, we have identified the S100A10-annexin A2 complex and TRPM7 as the regulatory proteins for Maxi-Cl and VSOR/VRAC, respectively. In this review article, we summarize their biophysical and structural properties as well as their physiological roles by comparing with each other on the basis of their molecular insights. We also point out unsolved important issues to be elucidated soon in the future. |
| first_indexed | 2024-12-19T12:26:15Z |
| format | Article |
| id | doaj.art-0f9f17082b3443d288b812517d2ce886 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-19T12:26:15Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-0f9f17082b3443d288b812517d2ce8862022-12-21T20:21:34ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-12-011210.3389/fphys.2021.805148805148Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’sYasunobu Okada0Yasunobu Okada1Yasunobu Okada2Yasunobu Okada3Ravshan Z. Sabirov4Petr G. Merzlyak5Tomohiro Numata6Kaori Sato-Numata7Kaori Sato-Numata8National Institute for Physiological Sciences (NIPS), Okazaki, JapanDepartment of Physiology, School of Medicine, Aichi Medical University, Nagakute, JapanDepartment of Physiology, Kyoto Prefectural University of Medicine, Kyoto, JapanCardiovascular Research Institute, Yokohama City University, Yokohama, JapanLaboratory of Molecular Physiology, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanLaboratory of Molecular Physiology, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanDepartment of Integrative Physiology, Graduate School of Medicine, Akita University, Akita, JapanDepartment of Integrative Physiology, Graduate School of Medicine, Akita University, Akita, JapanJapan Society for the Promotion of Science, Tokyo, JapanMolecular identification was, at last, successfully accomplished for three types of anion channels that are all implicated in cell volume regulation/dysregulation. LRRC8A plus LRRC8C/D/E, SLCO2A1, and TMEM206 were shown to be the core or pore-forming molecules of the volume-sensitive outwardly rectifying anion channel (VSOR) also called the volume-regulated anion channel (VRAC), the large-conductance maxi-anion channel (Maxi-Cl), and the acid-sensitive outwardly rectifying anion channel (ASOR) also called the proton-activated anion channel (PAC) in 2014, 2017, and 2019, respectively. More recently in 2020 and 2021, we have identified the S100A10-annexin A2 complex and TRPM7 as the regulatory proteins for Maxi-Cl and VSOR/VRAC, respectively. In this review article, we summarize their biophysical and structural properties as well as their physiological roles by comparing with each other on the basis of their molecular insights. We also point out unsolved important issues to be elucidated soon in the future.https://www.frontiersin.org/articles/10.3389/fphys.2021.805148/fullvolume-related anion channelsLRRC8ASLCO2A1TMEM206TRPM7cell swelling |
| spellingShingle | Yasunobu Okada Yasunobu Okada Yasunobu Okada Yasunobu Okada Ravshan Z. Sabirov Petr G. Merzlyak Tomohiro Numata Kaori Sato-Numata Kaori Sato-Numata Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s Frontiers in Physiology volume-related anion channels LRRC8A SLCO2A1 TMEM206 TRPM7 cell swelling |
| title | Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s |
| title_full | Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s |
| title_fullStr | Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s |
| title_full_unstemmed | Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s |
| title_short | Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s |
| title_sort | properties structures and physiological roles of three types of anion channels molecularly identified in the 2010 s |
| topic | volume-related anion channels LRRC8A SLCO2A1 TMEM206 TRPM7 cell swelling |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.805148/full |
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