In Vitro Models in BiocompatibilityAssessment for Biomedical-Grade Chitosan Derivatives in Wound Management
One of the ultimate goals of wound healing research is to find effective healing techniques that utilize the regeneration of similar tissues. This involves the modification of various wound dressing biomaterials for proper wound management. The biopolymer chitosan (b-1,4-D-glucosamine) has natural b...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2009-03-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-0067/10/3/1300/ |
| _version_ | 1811259825535844352 |
|---|---|
| author | Lim Chin Keong Ahmad Sukari Halim |
| author_facet | Lim Chin Keong Ahmad Sukari Halim |
| author_sort | Lim Chin Keong |
| collection | DOAJ |
| description | One of the ultimate goals of wound healing research is to find effective healing techniques that utilize the regeneration of similar tissues. This involves the modification of various wound dressing biomaterials for proper wound management. The biopolymer chitosan (b-1,4-D-glucosamine) has natural biocompatibility and biodegradability that render it suitable for wound management. By definition, a biocompatible biomaterial does not have toxic or injurious effects on biological systems. Chemical and physical modifications of chitosan influence its biocompatibility and biodegradability to an uncertain degree. Hence, the modified biomedical-grade of chitosan derivatives should be pre-examined in vitro in order to produce high-quality, biocompatible dressings. In vitro toxicity examinations are more favorable than those performed in vivo, as the results are more reproducible and predictive. In this paper, basic in vitro tools were used to evaluate cellular and molecular responses with regard to the biocompatibility of biomedical-grade chitosan. Three paramount experimental parameters of biocompatibility in vitro namely cytocompatibility, genotoxicity and skin pro-inflammatory cytokine expression, were generally reviewed for biomedical-grade chitosan as wound dressing. |
| first_indexed | 2024-04-12T18:38:24Z |
| format | Article |
| id | doaj.art-0f9fb4537fc24a5cacebb9e68afa2e57 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T18:38:24Z |
| publishDate | 2009-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0f9fb4537fc24a5cacebb9e68afa2e572022-12-22T03:20:52ZengMDPI AGInternational Journal of Molecular Sciences1422-00672009-03-011031300131310.3390/ijms10031300In Vitro Models in BiocompatibilityAssessment for Biomedical-Grade Chitosan Derivatives in Wound ManagementLim Chin KeongAhmad Sukari HalimOne of the ultimate goals of wound healing research is to find effective healing techniques that utilize the regeneration of similar tissues. This involves the modification of various wound dressing biomaterials for proper wound management. The biopolymer chitosan (b-1,4-D-glucosamine) has natural biocompatibility and biodegradability that render it suitable for wound management. By definition, a biocompatible biomaterial does not have toxic or injurious effects on biological systems. Chemical and physical modifications of chitosan influence its biocompatibility and biodegradability to an uncertain degree. Hence, the modified biomedical-grade of chitosan derivatives should be pre-examined in vitro in order to produce high-quality, biocompatible dressings. In vitro toxicity examinations are more favorable than those performed in vivo, as the results are more reproducible and predictive. In this paper, basic in vitro tools were used to evaluate cellular and molecular responses with regard to the biocompatibility of biomedical-grade chitosan. Three paramount experimental parameters of biocompatibility in vitro namely cytocompatibility, genotoxicity and skin pro-inflammatory cytokine expression, were generally reviewed for biomedical-grade chitosan as wound dressing.http://www.mdpi.com/1422-0067/10/3/1300/biopolymerchitosanbiocompatibilitybiomedical-grade chitosanin vitro toxicity examinationscytocompatibilitygenotoxicityskin pro-inflammatory cytokine expression |
| spellingShingle | Lim Chin Keong Ahmad Sukari Halim In Vitro Models in BiocompatibilityAssessment for Biomedical-Grade Chitosan Derivatives in Wound Management International Journal of Molecular Sciences biopolymer chitosan biocompatibility biomedical-grade chitosan in vitro toxicity examinations cytocompatibility genotoxicity skin pro-inflammatory cytokine expression |
| title | In Vitro Models in BiocompatibilityAssessment for Biomedical-Grade Chitosan Derivatives in Wound Management |
| title_full | In Vitro Models in BiocompatibilityAssessment for Biomedical-Grade Chitosan Derivatives in Wound Management |
| title_fullStr | In Vitro Models in BiocompatibilityAssessment for Biomedical-Grade Chitosan Derivatives in Wound Management |
| title_full_unstemmed | In Vitro Models in BiocompatibilityAssessment for Biomedical-Grade Chitosan Derivatives in Wound Management |
| title_short | In Vitro Models in BiocompatibilityAssessment for Biomedical-Grade Chitosan Derivatives in Wound Management |
| title_sort | in vitro models in biocompatibilityassessment for biomedical grade chitosan derivatives in wound management |
| topic | biopolymer chitosan biocompatibility biomedical-grade chitosan in vitro toxicity examinations cytocompatibility genotoxicity skin pro-inflammatory cytokine expression |
| url | http://www.mdpi.com/1422-0067/10/3/1300/ |
| work_keys_str_mv | AT limchinkeong invitromodelsinbiocompatibilityassessmentforbiomedicalgradechitosanderivativesinwoundmanagement AT ahmadsukarihalim invitromodelsinbiocompatibilityassessmentforbiomedicalgradechitosanderivativesinwoundmanagement |