Evaluation of immunogenicity post two doses of inactivated SARS-CoV-2 vaccine, Covaxin after six months
We have evaluated the immunogenicity of two dose of Covaxin given at a one-month interval to two adult populations, i.e. COVID-19 naïve-vaccinated individuals (n = 118) and COVID-19 recovered individuals (n = 128) with the vaccination. The immune response in the study population were assessed at thr...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2022.2156753 |
| _version_ | 1797673082598457344 |
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| author | Rima R. Sahay Pragya D. Yadav Ashok Nandapurkar Rutuja Dhawde Annasaheb Suryawanshi Deepak Y. Patil Anita M. Shete Gajanan N. Sapkal Milind Kulkarni Yogesh K. Gurav Gururaj R. Deshpande Jagdevi S. Ghodke Rajlaxmi Jain Raj Hawale Kaumudi Kalele Jyoti Yemul Pranita Gawande Priya Abraham |
| author_facet | Rima R. Sahay Pragya D. Yadav Ashok Nandapurkar Rutuja Dhawde Annasaheb Suryawanshi Deepak Y. Patil Anita M. Shete Gajanan N. Sapkal Milind Kulkarni Yogesh K. Gurav Gururaj R. Deshpande Jagdevi S. Ghodke Rajlaxmi Jain Raj Hawale Kaumudi Kalele Jyoti Yemul Pranita Gawande Priya Abraham |
| author_sort | Rima R. Sahay |
| collection | DOAJ |
| description | We have evaluated the immunogenicity of two dose of Covaxin given at a one-month interval to two adult populations, i.e. COVID-19 naïve-vaccinated individuals (n = 118) and COVID-19 recovered individuals (n = 128) with the vaccination. The immune response in the study population were assessed at three follow-ups, namely at one month post first dose, one and six months after the second dose. The persistence of S1RBD IgG and neutralizing antibodies for six months post vaccination was observed at different time intervals. The enhanced immune response was observed in both the participant groups. The study emphasizes the need for a booster dose post six months of vaccination. |
| first_indexed | 2024-03-11T21:39:26Z |
| format | Article |
| id | doaj.art-0f9fc7f50b734e8480929814efe02eb3 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T21:39:26Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-0f9fc7f50b734e8480929814efe02eb32023-09-26T13:25:47ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2022-12-0118710.1080/21645515.2022.21567532156753Evaluation of immunogenicity post two doses of inactivated SARS-CoV-2 vaccine, Covaxin after six monthsRima R. Sahay0Pragya D. Yadav1Ashok Nandapurkar2Rutuja Dhawde3Annasaheb Suryawanshi4Deepak Y. Patil5Anita M. Shete6Gajanan N. Sapkal7Milind Kulkarni8Yogesh K. Gurav9Gururaj R. Deshpande10Jagdevi S. Ghodke11Rajlaxmi Jain12Raj Hawale13Kaumudi Kalele14Jyoti Yemul15Pranita Gawande16Priya Abraham17Indian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyAundh Chest HospitalIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyAundh Chest HospitalIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyAundh Chest HospitalIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyWe have evaluated the immunogenicity of two dose of Covaxin given at a one-month interval to two adult populations, i.e. COVID-19 naïve-vaccinated individuals (n = 118) and COVID-19 recovered individuals (n = 128) with the vaccination. The immune response in the study population were assessed at three follow-ups, namely at one month post first dose, one and six months after the second dose. The persistence of S1RBD IgG and neutralizing antibodies for six months post vaccination was observed at different time intervals. The enhanced immune response was observed in both the participant groups. The study emphasizes the need for a booster dose post six months of vaccination.http://dx.doi.org/10.1080/21645515.2022.2156753sars-cov-2covaxinadult populationimmunogenicity |
| spellingShingle | Rima R. Sahay Pragya D. Yadav Ashok Nandapurkar Rutuja Dhawde Annasaheb Suryawanshi Deepak Y. Patil Anita M. Shete Gajanan N. Sapkal Milind Kulkarni Yogesh K. Gurav Gururaj R. Deshpande Jagdevi S. Ghodke Rajlaxmi Jain Raj Hawale Kaumudi Kalele Jyoti Yemul Pranita Gawande Priya Abraham Evaluation of immunogenicity post two doses of inactivated SARS-CoV-2 vaccine, Covaxin after six months Human Vaccines & Immunotherapeutics sars-cov-2 covaxin adult population immunogenicity |
| title | Evaluation of immunogenicity post two doses of inactivated SARS-CoV-2 vaccine, Covaxin after six months |
| title_full | Evaluation of immunogenicity post two doses of inactivated SARS-CoV-2 vaccine, Covaxin after six months |
| title_fullStr | Evaluation of immunogenicity post two doses of inactivated SARS-CoV-2 vaccine, Covaxin after six months |
| title_full_unstemmed | Evaluation of immunogenicity post two doses of inactivated SARS-CoV-2 vaccine, Covaxin after six months |
| title_short | Evaluation of immunogenicity post two doses of inactivated SARS-CoV-2 vaccine, Covaxin after six months |
| title_sort | evaluation of immunogenicity post two doses of inactivated sars cov 2 vaccine covaxin after six months |
| topic | sars-cov-2 covaxin adult population immunogenicity |
| url | http://dx.doi.org/10.1080/21645515.2022.2156753 |
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