SARS-CoV-2 viral dynamics in non-human primates.
Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large b...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-03-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1008785 |
| _version_ | 1819008101018238976 |
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| author | Antonio Gonçalves Pauline Maisonnasse Flora Donati Mélanie Albert Sylvie Behillil Vanessa Contreras Thibaut Naninck Romain Marlin Caroline Solas Andres Pizzorno Julien Lemaitre Nidhal Kahlaoui Olivier Terrier Raphael Ho Tsong Fang Vincent Enouf Nathalie Dereuddre-Bosquet Angela Brisebarre Franck Touret Catherine Chapon Bruno Hoen Bruno Lina Manuel Rosa Calatrava Xavier de Lamballerie France Mentré Roger Le Grand Sylvie van der Werf Jérémie Guedj |
| author_facet | Antonio Gonçalves Pauline Maisonnasse Flora Donati Mélanie Albert Sylvie Behillil Vanessa Contreras Thibaut Naninck Romain Marlin Caroline Solas Andres Pizzorno Julien Lemaitre Nidhal Kahlaoui Olivier Terrier Raphael Ho Tsong Fang Vincent Enouf Nathalie Dereuddre-Bosquet Angela Brisebarre Franck Touret Catherine Chapon Bruno Hoen Bruno Lina Manuel Rosa Calatrava Xavier de Lamballerie France Mentré Roger Le Grand Sylvie van der Werf Jérémie Guedj |
| author_sort | Antonio Gonçalves |
| collection | DOAJ |
| description | Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large burst size (>104 virus) and a within-host reproductive basic number of approximately 6 and 4 in nasopharyngeal and tracheal compartment, respectively. After peak viral load, infected cells were rapidly lost with a half-life of 9 hours, with no significant association between cytokine elevation and clearance, leading to a median time to viral clearance of 10 days, consistent with observations in mild human infections. Given these parameter estimates, we predict that a prophylactic treatment blocking 90% of viral production or viral infection could prevent viral growth. In conclusion, our results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments. |
| first_indexed | 2024-12-21T00:35:07Z |
| format | Article |
| id | doaj.art-0fa0b9d2f5e5421e8a4721a215607b84 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-21T00:35:07Z |
| publishDate | 2021-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-0fa0b9d2f5e5421e8a4721a215607b842022-12-21T19:21:49ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582021-03-01173e100878510.1371/journal.pcbi.1008785SARS-CoV-2 viral dynamics in non-human primates.Antonio GonçalvesPauline MaisonnasseFlora DonatiMélanie AlbertSylvie BehillilVanessa ContrerasThibaut NaninckRomain MarlinCaroline SolasAndres PizzornoJulien LemaitreNidhal KahlaouiOlivier TerrierRaphael Ho Tsong FangVincent EnoufNathalie Dereuddre-BosquetAngela BrisebarreFranck TouretCatherine ChaponBruno HoenBruno LinaManuel Rosa CalatravaXavier de LamballerieFrance MentréRoger Le GrandSylvie van der WerfJérémie GuedjNon-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large burst size (>104 virus) and a within-host reproductive basic number of approximately 6 and 4 in nasopharyngeal and tracheal compartment, respectively. After peak viral load, infected cells were rapidly lost with a half-life of 9 hours, with no significant association between cytokine elevation and clearance, leading to a median time to viral clearance of 10 days, consistent with observations in mild human infections. Given these parameter estimates, we predict that a prophylactic treatment blocking 90% of viral production or viral infection could prevent viral growth. In conclusion, our results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.https://doi.org/10.1371/journal.pcbi.1008785 |
| spellingShingle | Antonio Gonçalves Pauline Maisonnasse Flora Donati Mélanie Albert Sylvie Behillil Vanessa Contreras Thibaut Naninck Romain Marlin Caroline Solas Andres Pizzorno Julien Lemaitre Nidhal Kahlaoui Olivier Terrier Raphael Ho Tsong Fang Vincent Enouf Nathalie Dereuddre-Bosquet Angela Brisebarre Franck Touret Catherine Chapon Bruno Hoen Bruno Lina Manuel Rosa Calatrava Xavier de Lamballerie France Mentré Roger Le Grand Sylvie van der Werf Jérémie Guedj SARS-CoV-2 viral dynamics in non-human primates. PLoS Computational Biology |
| title | SARS-CoV-2 viral dynamics in non-human primates. |
| title_full | SARS-CoV-2 viral dynamics in non-human primates. |
| title_fullStr | SARS-CoV-2 viral dynamics in non-human primates. |
| title_full_unstemmed | SARS-CoV-2 viral dynamics in non-human primates. |
| title_short | SARS-CoV-2 viral dynamics in non-human primates. |
| title_sort | sars cov 2 viral dynamics in non human primates |
| url | https://doi.org/10.1371/journal.pcbi.1008785 |
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