The thalamus as a low pass filter: filtering at the cellular level does not equate with filtering at the network level.
In the mammalian central nervous system, most sensory information passes through primary sensory thalamic nuclei, however the consequence of this remains unclear. Various propositions exist, likening the thalamus to a gate, or a high pass filter. Here, using a simple leaky integrate and fire model b...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-01-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncir.2015.00089/full |
| _version_ | 1818197442165735424 |
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| author | William Martin Connelly William Martin Connelly Michael eLaing Adam Clarke Errington Vincenzo eCrunelli Vincenzo eCrunelli |
| author_facet | William Martin Connelly William Martin Connelly Michael eLaing Adam Clarke Errington Vincenzo eCrunelli Vincenzo eCrunelli |
| author_sort | William Martin Connelly |
| collection | DOAJ |
| description | In the mammalian central nervous system, most sensory information passes through primary sensory thalamic nuclei, however the consequence of this remains unclear. Various propositions exist, likening the thalamus to a gate, or a high pass filter. Here, using a simple leaky integrate and fire model based on physiological parameters, we show that the thalamus behaves akin to a low pass filter. Specifically, as individual cells in the thalamus rely on consistent drive to spike, stimuli that is rapidly and continuously changing over time such that it activates sensory cells with different receptive fields are unable to drive thalamic spiking. This means that thalamic encoding is robust to sensory noise, however it induces a lag in sensory representation. Thus the thalamus stabilises encoding of sensory information, at the cost of response rate. |
| first_indexed | 2024-12-12T01:50:02Z |
| format | Article |
| id | doaj.art-0fa11fd667e94ec888bc3b378e028726 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-12T01:50:02Z |
| publishDate | 2016-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-0fa11fd667e94ec888bc3b378e0287262022-12-22T00:42:31ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102016-01-01910.3389/fncir.2015.00089170550The thalamus as a low pass filter: filtering at the cellular level does not equate with filtering at the network level.William Martin Connelly0William Martin Connelly1Michael eLaing2Adam Clarke Errington3Vincenzo eCrunelli4Vincenzo eCrunelli5Australian National UniversityCardiff UniversityCardiff UniversityCardiff UniversityCardiff UniversityUniversity of MaltaIn the mammalian central nervous system, most sensory information passes through primary sensory thalamic nuclei, however the consequence of this remains unclear. Various propositions exist, likening the thalamus to a gate, or a high pass filter. Here, using a simple leaky integrate and fire model based on physiological parameters, we show that the thalamus behaves akin to a low pass filter. Specifically, as individual cells in the thalamus rely on consistent drive to spike, stimuli that is rapidly and continuously changing over time such that it activates sensory cells with different receptive fields are unable to drive thalamic spiking. This means that thalamic encoding is robust to sensory noise, however it induces a lag in sensory representation. Thus the thalamus stabilises encoding of sensory information, at the cost of response rate.http://journal.frontiersin.org/Journal/10.3389/fncir.2015.00089/fullThalamusSensory Neurosciencecomputational neuroscienceintegrate-and-fire neuronneural noise |
| spellingShingle | William Martin Connelly William Martin Connelly Michael eLaing Adam Clarke Errington Vincenzo eCrunelli Vincenzo eCrunelli The thalamus as a low pass filter: filtering at the cellular level does not equate with filtering at the network level. Frontiers in Neural Circuits Thalamus Sensory Neuroscience computational neuroscience integrate-and-fire neuron neural noise |
| title | The thalamus as a low pass filter: filtering at the cellular level does not equate with filtering at the network level. |
| title_full | The thalamus as a low pass filter: filtering at the cellular level does not equate with filtering at the network level. |
| title_fullStr | The thalamus as a low pass filter: filtering at the cellular level does not equate with filtering at the network level. |
| title_full_unstemmed | The thalamus as a low pass filter: filtering at the cellular level does not equate with filtering at the network level. |
| title_short | The thalamus as a low pass filter: filtering at the cellular level does not equate with filtering at the network level. |
| title_sort | thalamus as a low pass filter filtering at the cellular level does not equate with filtering at the network level |
| topic | Thalamus Sensory Neuroscience computational neuroscience integrate-and-fire neuron neural noise |
| url | http://journal.frontiersin.org/Journal/10.3389/fncir.2015.00089/full |
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