Listeria monocytogenes TcyKLMN Cystine/Cysteine Transporter Facilitates Glutathione Synthesis and Virulence Gene Expression

Listeria monocytogenes TcyKLMN Cystine/Cysteine Transporter Facilitates Glutathione Synthesis and Virulence Gene Expression

ABSTRACT Listeria monocytogenes is a saprophyte and a human intracellular pathogen. Upon invasion into mammalian cells, it senses multiple metabolic and environmental signals that collectively trigger its transition to the pathogenic state. One of these signals is the tripeptide glutathione, which a...

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Bibliographic Details
Main Authors: Moran Brenner, Sivan Friedman, Adi Haber, Nurit Livnat-Levanon, Ilya Borovok, Nadejda Sigal, Oded Lewinson, Anat A. Herskovits
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mBio
Subjects:
Listeria monocytogenes
glutathione biosynthesis
GSH
cystine/cysteine importer
branched-chain amino acids
BCAA
Online Access:https://journals.asm.org/doi/10.1128/mbio.00448-22

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