A quantitative modelling approach to zebrafish pigment pattern formation
Pattern formation is a key aspect of development. Adult zebrafish exhibit a striking striped pattern generated through the self-organisation of three different chromatophores. Numerous investigations have revealed a multitude of individual cell-cell interactions important for this self-organisation,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-07-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/52998 |
| _version_ | 1828204000534593536 |
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| author | Jennifer P Owen Robert N Kelsh Christian A Yates |
| author_facet | Jennifer P Owen Robert N Kelsh Christian A Yates |
| author_sort | Jennifer P Owen |
| collection | DOAJ |
| description | Pattern formation is a key aspect of development. Adult zebrafish exhibit a striking striped pattern generated through the self-organisation of three different chromatophores. Numerous investigations have revealed a multitude of individual cell-cell interactions important for this self-organisation, but it has remained unclear whether these known biological rules were sufficient to explain pattern formation. To test this, we present an individual-based mathematical model incorporating all the important cell-types and known interactions. The model qualitatively and quantitatively reproduces wild type and mutant pigment pattern development. We use it to resolve a number of outstanding biological uncertainties, including the roles of domain growth and the initial iridophore stripe, and to generate hypotheses about the functions of leopard. We conclude that our rule-set is sufficient to recapitulate wild-type and mutant patterns. Our work now leads the way for further in silico exploration of the developmental and evolutionary implications of this pigment patterning system. |
| first_indexed | 2024-04-12T12:15:17Z |
| format | Article |
| id | doaj.art-0fa2e796d77240ba9b84f496bf0aed6c |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T12:15:17Z |
| publishDate | 2020-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-0fa2e796d77240ba9b84f496bf0aed6c2022-12-22T03:33:27ZengeLife Sciences Publications LtdeLife2050-084X2020-07-01910.7554/eLife.52998A quantitative modelling approach to zebrafish pigment pattern formationJennifer P Owen0https://orcid.org/0000-0001-8440-6822Robert N Kelsh1Christian A Yates2https://orcid.org/0000-0003-0461-7297Department of Biology and Biochemistry and Department of Mathematical Sciences, University of Bath, Claverton Down, Bath, United KingdomDepartment of Biology and Biochemistry and Department of Mathematical Sciences, University of Bath, Claverton Down, Bath, United KingdomDepartment of Biology and Biochemistry and Department of Mathematical Sciences, University of Bath, Claverton Down, Bath, United KingdomPattern formation is a key aspect of development. Adult zebrafish exhibit a striking striped pattern generated through the self-organisation of three different chromatophores. Numerous investigations have revealed a multitude of individual cell-cell interactions important for this self-organisation, but it has remained unclear whether these known biological rules were sufficient to explain pattern formation. To test this, we present an individual-based mathematical model incorporating all the important cell-types and known interactions. The model qualitatively and quantitatively reproduces wild type and mutant pigment pattern development. We use it to resolve a number of outstanding biological uncertainties, including the roles of domain growth and the initial iridophore stripe, and to generate hypotheses about the functions of leopard. We conclude that our rule-set is sufficient to recapitulate wild-type and mutant patterns. Our work now leads the way for further in silico exploration of the developmental and evolutionary implications of this pigment patterning system.https://elifesciences.org/articles/52998ZebrafishDanio reriodanio |
| spellingShingle | Jennifer P Owen Robert N Kelsh Christian A Yates A quantitative modelling approach to zebrafish pigment pattern formation eLife Zebrafish Danio rerio danio |
| title | A quantitative modelling approach to zebrafish pigment pattern formation |
| title_full | A quantitative modelling approach to zebrafish pigment pattern formation |
| title_fullStr | A quantitative modelling approach to zebrafish pigment pattern formation |
| title_full_unstemmed | A quantitative modelling approach to zebrafish pigment pattern formation |
| title_short | A quantitative modelling approach to zebrafish pigment pattern formation |
| title_sort | quantitative modelling approach to zebrafish pigment pattern formation |
| topic | Zebrafish Danio rerio danio |
| url | https://elifesciences.org/articles/52998 |
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