Control Theory and Systems Biology: Potential Applications in Neurodegeneration and Search for Therapeutic Targets
Control theory, a well-established discipline in engineering and mathematics, has found novel applications in systems biology. This interdisciplinary approach leverages the principles of feedback control and regulation to gain insights into the complex dynamics of cellular and molecular networks und...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/1/365 |
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| author | Andrea Angarita-Rodríguez Yeimy González-Giraldo Juan J. Rubio-Mesa Andrés Felipe Aristizábal Andrés Pinzón Janneth González |
| author_facet | Andrea Angarita-Rodríguez Yeimy González-Giraldo Juan J. Rubio-Mesa Andrés Felipe Aristizábal Andrés Pinzón Janneth González |
| author_sort | Andrea Angarita-Rodríguez |
| collection | DOAJ |
| description | Control theory, a well-established discipline in engineering and mathematics, has found novel applications in systems biology. This interdisciplinary approach leverages the principles of feedback control and regulation to gain insights into the complex dynamics of cellular and molecular networks underlying chronic diseases, including neurodegeneration. By modeling and analyzing these intricate systems, control theory provides a framework to understand the pathophysiology and identify potential therapeutic targets. Therefore, this review examines the most widely used control methods in conjunction with genomic-scale metabolic models in the steady state of the multi-omics type. According to our research, this approach involves integrating experimental data, mathematical modeling, and computational analyses to simulate and control complex biological systems. In this review, we find that the most significant application of this methodology is associated with cancer, leaving a lack of knowledge in neurodegenerative models. However, this methodology, mainly associated with the Minimal Dominant Set (MDS), has provided a starting point for identifying therapeutic targets for drug development and personalized treatment strategies, paving the way for more effective therapies. |
| first_indexed | 2024-03-08T15:04:59Z |
| format | Article |
| id | doaj.art-0fa339f45f0642b69da28a12367b946c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T15:04:59Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0fa339f45f0642b69da28a12367b946c2024-01-10T14:59:12ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0125136510.3390/ijms25010365Control Theory and Systems Biology: Potential Applications in Neurodegeneration and Search for Therapeutic TargetsAndrea Angarita-Rodríguez0Yeimy González-Giraldo1Juan J. Rubio-Mesa2Andrés Felipe Aristizábal3Andrés Pinzón4Janneth González5Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Edf. Carlos Ortiz, Oficina 107, Cra. 7 40-62, Bogotá 110231, ColombiaDepartamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Edf. Carlos Ortiz, Oficina 107, Cra. 7 40-62, Bogotá 110231, ColombiaDepartamento de Estadística, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá 111321, ColombiaDepartamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Edf. Carlos Ortiz, Oficina 107, Cra. 7 40-62, Bogotá 110231, ColombiaLaboratorio de Bioinformática y Biología de Sistemas, Universidad Nacional de Colombia, Bogotá 111321, ColombiaDepartamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Edf. Carlos Ortiz, Oficina 107, Cra. 7 40-62, Bogotá 110231, ColombiaControl theory, a well-established discipline in engineering and mathematics, has found novel applications in systems biology. This interdisciplinary approach leverages the principles of feedback control and regulation to gain insights into the complex dynamics of cellular and molecular networks underlying chronic diseases, including neurodegeneration. By modeling and analyzing these intricate systems, control theory provides a framework to understand the pathophysiology and identify potential therapeutic targets. Therefore, this review examines the most widely used control methods in conjunction with genomic-scale metabolic models in the steady state of the multi-omics type. According to our research, this approach involves integrating experimental data, mathematical modeling, and computational analyses to simulate and control complex biological systems. In this review, we find that the most significant application of this methodology is associated with cancer, leaving a lack of knowledge in neurodegenerative models. However, this methodology, mainly associated with the Minimal Dominant Set (MDS), has provided a starting point for identifying therapeutic targets for drug development and personalized treatment strategies, paving the way for more effective therapies.https://www.mdpi.com/1422-0067/25/1/365control theorysystems biologyneurodegenerative diseasesgenome-scale metabolic networks |
| spellingShingle | Andrea Angarita-Rodríguez Yeimy González-Giraldo Juan J. Rubio-Mesa Andrés Felipe Aristizábal Andrés Pinzón Janneth González Control Theory and Systems Biology: Potential Applications in Neurodegeneration and Search for Therapeutic Targets International Journal of Molecular Sciences control theory systems biology neurodegenerative diseases genome-scale metabolic networks |
| title | Control Theory and Systems Biology: Potential Applications in Neurodegeneration and Search for Therapeutic Targets |
| title_full | Control Theory and Systems Biology: Potential Applications in Neurodegeneration and Search for Therapeutic Targets |
| title_fullStr | Control Theory and Systems Biology: Potential Applications in Neurodegeneration and Search for Therapeutic Targets |
| title_full_unstemmed | Control Theory and Systems Biology: Potential Applications in Neurodegeneration and Search for Therapeutic Targets |
| title_short | Control Theory and Systems Biology: Potential Applications in Neurodegeneration and Search for Therapeutic Targets |
| title_sort | control theory and systems biology potential applications in neurodegeneration and search for therapeutic targets |
| topic | control theory systems biology neurodegenerative diseases genome-scale metabolic networks |
| url | https://www.mdpi.com/1422-0067/25/1/365 |
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