Molecules and targets of antidiabetic interest
Background: The review is a comprehensive overview of targets of antidiabetic interest and molecules that are reported to possess modulatory effects on glucose homeostasis. Drugs available in the market to treat diabetes restore blood glucose levels to normal, but are associated with undesirable eff...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-02-01
|
| Series: | Phytomedicine Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031323001021 |
| _version_ | 1797324311227269120 |
|---|---|
| author | Kavishankar Gawli Kavya Sritha Bojja |
| author_facet | Kavishankar Gawli Kavya Sritha Bojja |
| author_sort | Kavishankar Gawli |
| collection | DOAJ |
| description | Background: The review is a comprehensive overview of targets of antidiabetic interest and molecules that are reported to possess modulatory effects on glucose homeostasis. Drugs available in the market to treat diabetes restore blood glucose levels to normal, but are associated with undesirable effects. This has compelled the investigators to search for a more benign candidate molecule that could counter the high levels of blood glucose, minimize, or diminish further complications and improve lifestyle. Methods: A literature survey was performed using the scientific databases viz., PubMed, Scopus, Google scholar and EMBASE. Results: Twenty targets and 233 molecules, their source, structure, chemical formula, IC50 values and mechanism of action are described. The review has focused on the growing interest in discovering novel targets such as antagonists of glucagon and glucocorticoids receptor, inhibitors of aldose reductase, fructose-1,6-bisphosphatase, and glycogen phosphorylase that have led to effective clinical development. The enzyme inhibitors, antagonists, agonists, and blockers of receptors are reported to be plant-derived metabolites and therefore, can target cellular and molecular mechanisms leading to glucose homeostasis. Conclusions: Overall, the information could serve as a guide for investigators and drug-based companies to explore the molecules for developing potential antidiabetic drug candidates with fewer or no side effects. |
| first_indexed | 2024-03-08T05:54:14Z |
| format | Article |
| id | doaj.art-0fa484ff9f6f48fb86afa1680162454d |
| institution | Directory Open Access Journal |
| issn | 2667-0313 |
| language | English |
| last_indexed | 2024-03-08T05:54:14Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj.art-0fa484ff9f6f48fb86afa1680162454d2024-02-05T04:32:20ZengElsevierPhytomedicine Plus2667-03132024-02-0141100506Molecules and targets of antidiabetic interestKavishankar Gawli0Kavya Sritha Bojja1Corresponding author at: Dept. of Life Sciences, Central University of Karnataka, Aland Road, Kalaburagi Dist., Kadaganchi, 585 367, India.; Department of Life Science, Central University of Karnataka, Kalaburagi, IndiaDepartment of Life Science, Central University of Karnataka, Kalaburagi, IndiaBackground: The review is a comprehensive overview of targets of antidiabetic interest and molecules that are reported to possess modulatory effects on glucose homeostasis. Drugs available in the market to treat diabetes restore blood glucose levels to normal, but are associated with undesirable effects. This has compelled the investigators to search for a more benign candidate molecule that could counter the high levels of blood glucose, minimize, or diminish further complications and improve lifestyle. Methods: A literature survey was performed using the scientific databases viz., PubMed, Scopus, Google scholar and EMBASE. Results: Twenty targets and 233 molecules, their source, structure, chemical formula, IC50 values and mechanism of action are described. The review has focused on the growing interest in discovering novel targets such as antagonists of glucagon and glucocorticoids receptor, inhibitors of aldose reductase, fructose-1,6-bisphosphatase, and glycogen phosphorylase that have led to effective clinical development. The enzyme inhibitors, antagonists, agonists, and blockers of receptors are reported to be plant-derived metabolites and therefore, can target cellular and molecular mechanisms leading to glucose homeostasis. Conclusions: Overall, the information could serve as a guide for investigators and drug-based companies to explore the molecules for developing potential antidiabetic drug candidates with fewer or no side effects.http://www.sciencedirect.com/science/article/pii/S2667031323001021DiabetesMoleculesMechanismTargetGlucose homeostasisSecondary metabolites |
| spellingShingle | Kavishankar Gawli Kavya Sritha Bojja Molecules and targets of antidiabetic interest Phytomedicine Plus Diabetes Molecules Mechanism Target Glucose homeostasis Secondary metabolites |
| title | Molecules and targets of antidiabetic interest |
| title_full | Molecules and targets of antidiabetic interest |
| title_fullStr | Molecules and targets of antidiabetic interest |
| title_full_unstemmed | Molecules and targets of antidiabetic interest |
| title_short | Molecules and targets of antidiabetic interest |
| title_sort | molecules and targets of antidiabetic interest |
| topic | Diabetes Molecules Mechanism Target Glucose homeostasis Secondary metabolites |
| url | http://www.sciencedirect.com/science/article/pii/S2667031323001021 |
| work_keys_str_mv | AT kavishankargawli moleculesandtargetsofantidiabeticinterest AT kavyasrithabojja moleculesandtargetsofantidiabeticinterest |