Comparing trimodal therapy with radical cystectomy in muscle-invasive bladder cancer: an updated meta-analysis
BackgroundWe conducted this meta-analysis to compare the two muscle-invasive bladder cancer (MIBC) treatment modalities in terms of cancer-specific survival (CSS) and other outcome indicators.MethodA systematic review and meta-analysis were performed in accordance with the Preferred Reporting Items...
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| Format: | Article |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2023.1276746/full |
| _version_ | 1827593454794833920 |
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| author | Ahmad R. Al-Qudimat Ahmad R. Al-Qudimat Kalpana Singh Laxmi K. Ojha Diala Alhaj Moustafa Mai Elaarag Raed M. Al-Zoubi Raed M. Al-Zoubi Raed M. Al-Zoubi Omar M. Aboumarzouk Omar M. Aboumarzouk |
| author_facet | Ahmad R. Al-Qudimat Ahmad R. Al-Qudimat Kalpana Singh Laxmi K. Ojha Diala Alhaj Moustafa Mai Elaarag Raed M. Al-Zoubi Raed M. Al-Zoubi Raed M. Al-Zoubi Omar M. Aboumarzouk Omar M. Aboumarzouk |
| author_sort | Ahmad R. Al-Qudimat |
| collection | DOAJ |
| description | BackgroundWe conducted this meta-analysis to compare the two muscle-invasive bladder cancer (MIBC) treatment modalities in terms of cancer-specific survival (CSS) and other outcome indicators.MethodA systematic review and meta-analysis were performed in accordance with the Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines. The search was conducted using various academic databases including Scopus, PubMed, Cochrane database, EMBASE, Chinese biomedical literature database, Wan fang databases, and China National Knowledge Internet databases between 1966 and December 2023. This review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) No. (CRD42023398977).ResultThis study included a total of 54,816 patients diagnosed with bladder cancer from 14 studies, of which 6,228 patients were assigned to the trimodal therapy (TMT) group and 48,588 patients were assigned to the radical cystectomy (RC) group. Based on the results, the RC group exhibited a higher rate of survival than the TMT group [pooled hazard ratio (HR) = 1.23, 95% CI: 1.18–1.28, Z = 1.46, P < 0.001]. In terms of CSS, patients in the RC group had a longer CSS compared with those in the TMT group (pooled HR = 1.47, 95% CI: 1.29–1.67, Z = 5.893, P < 0.001). Compared with RC, TMT is significantly associated with an increased risk of both types of mortality (pooled HR: 1.30, P < 0.001).ConclusionOverall, the findings of this meta-analysis suggest that RC treatment may be associated with improved overall survival. Moreover, it was observed that cancer-specific survival was significantly prolonged among patients in the RC group as opposed to those who received TMT. In addition, it was shown that patients who received TMT exhibited a higher risk of all-cause mortality when compared with those who underwent RC. |
| first_indexed | 2024-03-09T02:11:23Z |
| format | Article |
| id | doaj.art-0fa6f2eaa7a8467ab308f295c18f8525 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-03-09T02:11:23Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-0fa6f2eaa7a8467ab308f295c18f85252023-12-07T10:19:46ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2023-12-011010.3389/fsurg.2023.12767461276746Comparing trimodal therapy with radical cystectomy in muscle-invasive bladder cancer: an updated meta-analysisAhmad R. Al-Qudimat0Ahmad R. Al-Qudimat1Kalpana Singh2Laxmi K. Ojha3Diala Alhaj Moustafa4Mai Elaarag5Raed M. Al-Zoubi6Raed M. Al-Zoubi7Raed M. Al-Zoubi8Omar M. Aboumarzouk9Omar M. Aboumarzouk10Surgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, QatarDepartment of Public Health, College of Health Sciences, Qatar University, Doha, QatarDepartment of Nursing Research, Hamad Medical Corporation, Doha, QatarSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, QatarSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, QatarSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, QatarSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, QatarDepartment of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, QatarDepartment of Chemistry, College of Science, Jordan University of Science and Technology, Irbid, JordanSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, QatarSchool of Medicine, Dentistry and Nursing, The University of Glasgow, Glasgow, United KingdomBackgroundWe conducted this meta-analysis to compare the two muscle-invasive bladder cancer (MIBC) treatment modalities in terms of cancer-specific survival (CSS) and other outcome indicators.MethodA systematic review and meta-analysis were performed in accordance with the Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines. The search was conducted using various academic databases including Scopus, PubMed, Cochrane database, EMBASE, Chinese biomedical literature database, Wan fang databases, and China National Knowledge Internet databases between 1966 and December 2023. This review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) No. (CRD42023398977).ResultThis study included a total of 54,816 patients diagnosed with bladder cancer from 14 studies, of which 6,228 patients were assigned to the trimodal therapy (TMT) group and 48,588 patients were assigned to the radical cystectomy (RC) group. Based on the results, the RC group exhibited a higher rate of survival than the TMT group [pooled hazard ratio (HR) = 1.23, 95% CI: 1.18–1.28, Z = 1.46, P < 0.001]. In terms of CSS, patients in the RC group had a longer CSS compared with those in the TMT group (pooled HR = 1.47, 95% CI: 1.29–1.67, Z = 5.893, P < 0.001). Compared with RC, TMT is significantly associated with an increased risk of both types of mortality (pooled HR: 1.30, P < 0.001).ConclusionOverall, the findings of this meta-analysis suggest that RC treatment may be associated with improved overall survival. Moreover, it was observed that cancer-specific survival was significantly prolonged among patients in the RC group as opposed to those who received TMT. In addition, it was shown that patients who received TMT exhibited a higher risk of all-cause mortality when compared with those who underwent RC.https://www.frontiersin.org/articles/10.3389/fsurg.2023.1276746/fullcancerbladder preservingradical cystectomymuscle-invasivetrimodal |
| spellingShingle | Ahmad R. Al-Qudimat Ahmad R. Al-Qudimat Kalpana Singh Laxmi K. Ojha Diala Alhaj Moustafa Mai Elaarag Raed M. Al-Zoubi Raed M. Al-Zoubi Raed M. Al-Zoubi Omar M. Aboumarzouk Omar M. Aboumarzouk Comparing trimodal therapy with radical cystectomy in muscle-invasive bladder cancer: an updated meta-analysis Frontiers in Surgery cancer bladder preserving radical cystectomy muscle-invasive trimodal |
| title | Comparing trimodal therapy with radical cystectomy in muscle-invasive bladder cancer: an updated meta-analysis |
| title_full | Comparing trimodal therapy with radical cystectomy in muscle-invasive bladder cancer: an updated meta-analysis |
| title_fullStr | Comparing trimodal therapy with radical cystectomy in muscle-invasive bladder cancer: an updated meta-analysis |
| title_full_unstemmed | Comparing trimodal therapy with radical cystectomy in muscle-invasive bladder cancer: an updated meta-analysis |
| title_short | Comparing trimodal therapy with radical cystectomy in muscle-invasive bladder cancer: an updated meta-analysis |
| title_sort | comparing trimodal therapy with radical cystectomy in muscle invasive bladder cancer an updated meta analysis |
| topic | cancer bladder preserving radical cystectomy muscle-invasive trimodal |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2023.1276746/full |
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