Association of Sjögrens Syndrome in Patients with Chronic Hepatitis Virus Infection: A Population-Based Analysis.
The association between Sjögren's syndrome (SS) and chronic hepatitis virus infection is inconclusive. Hepatitis B (HBV) and hepatitis C virus (HCV) infections are highly prevalent in Taiwan. We used a population-based case-control study to evaluate the associations between SS and HBV and HCV i...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4999293?pdf=render |
| _version_ | 1811320993759625216 |
|---|---|
| author | Chih-Ching Yeh Wen-Chang Wang Chien-Sheng Wu Fung-Chang Sung Chien-Tien Su Ying-Hua Shieh Shih-Ni Chang Fu-Hsiung Su |
| author_facet | Chih-Ching Yeh Wen-Chang Wang Chien-Sheng Wu Fung-Chang Sung Chien-Tien Su Ying-Hua Shieh Shih-Ni Chang Fu-Hsiung Su |
| author_sort | Chih-Ching Yeh |
| collection | DOAJ |
| description | The association between Sjögren's syndrome (SS) and chronic hepatitis virus infection is inconclusive. Hepatitis B (HBV) and hepatitis C virus (HCV) infections are highly prevalent in Taiwan. We used a population-based case-control study to evaluate the associations between SS and HBV and HCV infections.We identified 9,629 SS patients without other concomitant autoimmune diseases and 38,516 sex- and age-matched controls without SS from the Taiwan National Health Insurance claims data between 2000 and 2011. We utilized multivariate logistic regression to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of the associations between SS and HBV and HCV infections. Sex- and age-specific (<55 and ≥55 years) risks of SS were evaluated.The risk of SS was higher in patients with HCV than in those without chronic viral hepatitis (OR = 2.49, 95% CI = 2.16-2.86). Conversely, HBV infection was not associated with SS (OR = 1.10, 95% CI = 0.98-1.24). Younger HCV patients were at a higher risk for SS (<55 years: OR = 3.37, 95% CI = 2.62-4.35; ≥55 years: OR = 2.20, 95% CI = 1.84-2.62). Men with HCV were at a greater risk for SS (women: OR = 2.26, 95% CI = 1.94-2.63; men: OR = 4.22, 95% CI = 2.90-6.16). Only men with chronic HBV exhibited a higher risk of SS (OR = 1.61, 95% CI = 1.21-2.14).HCV infection was associated with SS; however, HBV only associated with SS in men. |
| first_indexed | 2024-04-13T13:10:22Z |
| format | Article |
| id | doaj.art-0fa8251421144028b05468063af36f60 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T13:10:22Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0fa8251421144028b05468063af36f602022-12-22T02:45:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01118e016195810.1371/journal.pone.0161958Association of Sjögrens Syndrome in Patients with Chronic Hepatitis Virus Infection: A Population-Based Analysis.Chih-Ching YehWen-Chang WangChien-Sheng WuFung-Chang SungChien-Tien SuYing-Hua ShiehShih-Ni ChangFu-Hsiung SuThe association between Sjögren's syndrome (SS) and chronic hepatitis virus infection is inconclusive. Hepatitis B (HBV) and hepatitis C virus (HCV) infections are highly prevalent in Taiwan. We used a population-based case-control study to evaluate the associations between SS and HBV and HCV infections.We identified 9,629 SS patients without other concomitant autoimmune diseases and 38,516 sex- and age-matched controls without SS from the Taiwan National Health Insurance claims data between 2000 and 2011. We utilized multivariate logistic regression to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of the associations between SS and HBV and HCV infections. Sex- and age-specific (<55 and ≥55 years) risks of SS were evaluated.The risk of SS was higher in patients with HCV than in those without chronic viral hepatitis (OR = 2.49, 95% CI = 2.16-2.86). Conversely, HBV infection was not associated with SS (OR = 1.10, 95% CI = 0.98-1.24). Younger HCV patients were at a higher risk for SS (<55 years: OR = 3.37, 95% CI = 2.62-4.35; ≥55 years: OR = 2.20, 95% CI = 1.84-2.62). Men with HCV were at a greater risk for SS (women: OR = 2.26, 95% CI = 1.94-2.63; men: OR = 4.22, 95% CI = 2.90-6.16). Only men with chronic HBV exhibited a higher risk of SS (OR = 1.61, 95% CI = 1.21-2.14).HCV infection was associated with SS; however, HBV only associated with SS in men.http://europepmc.org/articles/PMC4999293?pdf=render |
| spellingShingle | Chih-Ching Yeh Wen-Chang Wang Chien-Sheng Wu Fung-Chang Sung Chien-Tien Su Ying-Hua Shieh Shih-Ni Chang Fu-Hsiung Su Association of Sjögrens Syndrome in Patients with Chronic Hepatitis Virus Infection: A Population-Based Analysis. PLoS ONE |
| title | Association of Sjögrens Syndrome in Patients with Chronic Hepatitis Virus Infection: A Population-Based Analysis. |
| title_full | Association of Sjögrens Syndrome in Patients with Chronic Hepatitis Virus Infection: A Population-Based Analysis. |
| title_fullStr | Association of Sjögrens Syndrome in Patients with Chronic Hepatitis Virus Infection: A Population-Based Analysis. |
| title_full_unstemmed | Association of Sjögrens Syndrome in Patients with Chronic Hepatitis Virus Infection: A Population-Based Analysis. |
| title_short | Association of Sjögrens Syndrome in Patients with Chronic Hepatitis Virus Infection: A Population-Based Analysis. |
| title_sort | association of sjogrens syndrome in patients with chronic hepatitis virus infection a population based analysis |
| url | http://europepmc.org/articles/PMC4999293?pdf=render |
| work_keys_str_mv | AT chihchingyeh associationofsjogrenssyndromeinpatientswithchronichepatitisvirusinfectionapopulationbasedanalysis AT wenchangwang associationofsjogrenssyndromeinpatientswithchronichepatitisvirusinfectionapopulationbasedanalysis AT chienshengwu associationofsjogrenssyndromeinpatientswithchronichepatitisvirusinfectionapopulationbasedanalysis AT fungchangsung associationofsjogrenssyndromeinpatientswithchronichepatitisvirusinfectionapopulationbasedanalysis AT chientiensu associationofsjogrenssyndromeinpatientswithchronichepatitisvirusinfectionapopulationbasedanalysis AT yinghuashieh associationofsjogrenssyndromeinpatientswithchronichepatitisvirusinfectionapopulationbasedanalysis AT shihnichang associationofsjogrenssyndromeinpatientswithchronichepatitisvirusinfectionapopulationbasedanalysis AT fuhsiungsu associationofsjogrenssyndromeinpatientswithchronichepatitisvirusinfectionapopulationbasedanalysis |