Prenatal exposures to isoflavones and neurobehavioral development in children at 2 and 4 years of age: A birth cohort study
Isoflavones (ISOs) are plant-derived estrogen-like compounds, which were already proved with cognition benefits on elderly people. However, studies assessing the associations between prenatal ISOs exposure and children’s neurodevelopment are scarce. This study aimed to examine the associations betwe...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323006802 |
| _version_ | 1797744108452708352 |
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| author | Lin Zhu Yao Chen Maohua Miao Hong Liang Jianya Xi Yan Wang Kaige Yang Ziliang Wang Wei Yuan |
| author_facet | Lin Zhu Yao Chen Maohua Miao Hong Liang Jianya Xi Yan Wang Kaige Yang Ziliang Wang Wei Yuan |
| author_sort | Lin Zhu |
| collection | DOAJ |
| description | Isoflavones (ISOs) are plant-derived estrogen-like compounds, which were already proved with cognition benefits on elderly people. However, studies assessing the associations between prenatal ISOs exposure and children’s neurodevelopment are scarce. This study aimed to examine the associations between maternal urinary ISOs concentrations, including genistein (GEN), daidzein (DAD), glycitein (GLY), and metabolite equol (EQU), and children’s neurodevelopment, based on a Chinese cohort study. Participants in this study were pregnant women recruited at 12–16 weeks of gestation, and they provided a single spot urine sample for the ISOs assay. Neurodevelopment was measured using the Child Behavior Checklist (CBCL) at 2 and 4 years of age. Negative binomial regression analysis and Generalized Estimating Equation (GEE) were performed to examine the associations between maternal urinary ISOs concentrations and CBCL scores. Associations were observed between moderate levels of prenatal ISOs exposure and decreased risks of childhood neurobehavioral problems, while the highest level of prenatal ISOs exposure was associated with increased risks of neurobehavioral problems among children. The neuroprotective effects were consistently between moderate DAD exposure and specific neurobehavioral problems, across different ages and sexes. For example, compared with the lowest exposure level, the third quartile group was associated with less Anxious/Depressed problems in boys at 2 years of age (RR=0.72 (95%CI: 0.52, 0.99)), girls at 2 years of age (RR=0.70 (95%CI: 0.46, 1.06)), boys at 4 years of age (RR=0.73 (95%CI: 0.55, 0.96)), and girls at 4 years of age (RR=0.95 (95%CI: 0.68, 1.31)). |
| first_indexed | 2024-03-12T15:05:00Z |
| format | Article |
| id | doaj.art-0fa857d3e5344ffebbc782af4305e2cd |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-12T15:05:00Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-0fa857d3e5344ffebbc782af4305e2cd2023-08-13T04:51:53ZengElsevierEcotoxicology and Environmental Safety0147-65132023-09-01262115176Prenatal exposures to isoflavones and neurobehavioral development in children at 2 and 4 years of age: A birth cohort studyLin Zhu0Yao Chen1Maohua Miao2Hong Liang3Jianya Xi4Yan Wang5Kaige Yang6Ziliang Wang7Wei Yuan8Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, ChinaShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, ChinaShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, ChinaShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, ChinaShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, ChinaSchool of Pharmacy, Shanghai Jiaotong University, Shanghai, ChinaSchool of Pharmacy, Shanghai Jiaotong University, Shanghai, ChinaShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, China; Correspondence to: Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, 779 Lao Hu Min Road, Shanghai 200237, China.Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, ChinaIsoflavones (ISOs) are plant-derived estrogen-like compounds, which were already proved with cognition benefits on elderly people. However, studies assessing the associations between prenatal ISOs exposure and children’s neurodevelopment are scarce. This study aimed to examine the associations between maternal urinary ISOs concentrations, including genistein (GEN), daidzein (DAD), glycitein (GLY), and metabolite equol (EQU), and children’s neurodevelopment, based on a Chinese cohort study. Participants in this study were pregnant women recruited at 12–16 weeks of gestation, and they provided a single spot urine sample for the ISOs assay. Neurodevelopment was measured using the Child Behavior Checklist (CBCL) at 2 and 4 years of age. Negative binomial regression analysis and Generalized Estimating Equation (GEE) were performed to examine the associations between maternal urinary ISOs concentrations and CBCL scores. Associations were observed between moderate levels of prenatal ISOs exposure and decreased risks of childhood neurobehavioral problems, while the highest level of prenatal ISOs exposure was associated with increased risks of neurobehavioral problems among children. The neuroprotective effects were consistently between moderate DAD exposure and specific neurobehavioral problems, across different ages and sexes. For example, compared with the lowest exposure level, the third quartile group was associated with less Anxious/Depressed problems in boys at 2 years of age (RR=0.72 (95%CI: 0.52, 0.99)), girls at 2 years of age (RR=0.70 (95%CI: 0.46, 1.06)), boys at 4 years of age (RR=0.73 (95%CI: 0.55, 0.96)), and girls at 4 years of age (RR=0.95 (95%CI: 0.68, 1.31)).http://www.sciencedirect.com/science/article/pii/S0147651323006802Prenatal exposureIsoflavones(ISOs)Neurobehavioral developmentCohort study |
| spellingShingle | Lin Zhu Yao Chen Maohua Miao Hong Liang Jianya Xi Yan Wang Kaige Yang Ziliang Wang Wei Yuan Prenatal exposures to isoflavones and neurobehavioral development in children at 2 and 4 years of age: A birth cohort study Ecotoxicology and Environmental Safety Prenatal exposure Isoflavones(ISOs) Neurobehavioral development Cohort study |
| title | Prenatal exposures to isoflavones and neurobehavioral development in children at 2 and 4 years of age: A birth cohort study |
| title_full | Prenatal exposures to isoflavones and neurobehavioral development in children at 2 and 4 years of age: A birth cohort study |
| title_fullStr | Prenatal exposures to isoflavones and neurobehavioral development in children at 2 and 4 years of age: A birth cohort study |
| title_full_unstemmed | Prenatal exposures to isoflavones and neurobehavioral development in children at 2 and 4 years of age: A birth cohort study |
| title_short | Prenatal exposures to isoflavones and neurobehavioral development in children at 2 and 4 years of age: A birth cohort study |
| title_sort | prenatal exposures to isoflavones and neurobehavioral development in children at 2 and 4 years of age a birth cohort study |
| topic | Prenatal exposure Isoflavones(ISOs) Neurobehavioral development Cohort study |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323006802 |
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