Towards a functional understanding of protein N-terminal acetylation.
Protein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional implications include regulation of protein-protein interactions and targeting to membranes, as demonstrated by studies of a handful of proteins. Fifty years after its discovery, a potential general function...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-05-01
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| Series: | PLoS Biology |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21655309/pdf/?tool=EBI |
| _version_ | 1818834417931517952 |
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| author | Thomas Arnesen |
| author_facet | Thomas Arnesen |
| author_sort | Thomas Arnesen |
| collection | DOAJ |
| description | Protein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional implications include regulation of protein-protein interactions and targeting to membranes, as demonstrated by studies of a handful of proteins. Fifty years after its discovery, a potential general function of the N-terminal acetyl group carried by thousands of unique proteins remains enigmatic. However, recent functional data suggest roles for N-terminal acetylation as a degradation signal and as a determining factor for preventing protein targeting to the secretory pathway, thus highlighting N-terminal acetylation as a major determinant for the life and death of proteins. These contributions represent new and intriguing hypotheses that will guide the research in the years to come. |
| first_indexed | 2024-12-19T02:34:30Z |
| format | Article |
| id | doaj.art-0faccd58079e4e46ab83a328163896c2 |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-19T02:34:30Z |
| publishDate | 2011-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-0faccd58079e4e46ab83a328163896c22022-12-21T20:39:29ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852011-05-0195e100107410.1371/journal.pbio.1001074Towards a functional understanding of protein N-terminal acetylation.Thomas ArnesenProtein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional implications include regulation of protein-protein interactions and targeting to membranes, as demonstrated by studies of a handful of proteins. Fifty years after its discovery, a potential general function of the N-terminal acetyl group carried by thousands of unique proteins remains enigmatic. However, recent functional data suggest roles for N-terminal acetylation as a degradation signal and as a determining factor for preventing protein targeting to the secretory pathway, thus highlighting N-terminal acetylation as a major determinant for the life and death of proteins. These contributions represent new and intriguing hypotheses that will guide the research in the years to come.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21655309/pdf/?tool=EBI |
| spellingShingle | Thomas Arnesen Towards a functional understanding of protein N-terminal acetylation. PLoS Biology |
| title | Towards a functional understanding of protein N-terminal acetylation. |
| title_full | Towards a functional understanding of protein N-terminal acetylation. |
| title_fullStr | Towards a functional understanding of protein N-terminal acetylation. |
| title_full_unstemmed | Towards a functional understanding of protein N-terminal acetylation. |
| title_short | Towards a functional understanding of protein N-terminal acetylation. |
| title_sort | towards a functional understanding of protein n terminal acetylation |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21655309/pdf/?tool=EBI |
| work_keys_str_mv | AT thomasarnesen towardsafunctionalunderstandingofproteinnterminalacetylation |