Alzheimer's disease gene signature says: beware of brain viral infections
<p>Abstract</p> <p>Background</p> <p>Recent findings from a genome wide association investigation in a large cohort of patients with Alzheimer's disease (AD) and non demented controls (CTR) showed that a limited set of genes was in a strong association (p > l0&l...
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| Format: | Article |
| Language: | English |
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BMC
2010-12-01
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| Series: | Immunity & Ageing |
| Online Access: | http://www.immunityageing.com/content/7/1/16 |
| _version_ | 1818661848085430272 |
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| author | Ianni Manuela Carbone Ilaria Porcellini Elisa Licastro Federico |
| author_facet | Ianni Manuela Carbone Ilaria Porcellini Elisa Licastro Federico |
| author_sort | Ianni Manuela |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Recent findings from a genome wide association investigation in a large cohort of patients with Alzheimer's disease (AD) and non demented controls (CTR) showed that a limited set of genes was in a strong association (p > l0<sup>-5</sup>) with the disease.</p> <p>Presentation of the hypothesis</p> <p>In this report we suggest that the polymorphism association in 8 of these genes is consistent with a non conventional interpretation of AD etiology.</p> <p>Nectin-2 (NC-2), apolipoprotein E (APOE), glycoprotein carcinoembryonic antigen related cell adhesion molecule- 16 (CEACAM-16), B-cell lymphoma-3 (Bcl-3), translocase of outer mitochondrial membrane 40 homolog (T0MM-40), complement receptor-1 (CR-l), APOJ or clusterin and C-type lectin domain A family-16 member (CLEC-16A) result in a genetic signature that might affect individual brain susceptibility to infection by herpes virus family during aging, leading to neuronal loss, inflammation and amyloid deposition.</p> <p>Implications of the hypothesis</p> <p>We hypothesized that such genetic trait may predispose to AD via complex and diverse mechanisms each contributing to an increase of individual susceptibility to brain viral infections</p> |
| first_indexed | 2024-12-17T04:51:34Z |
| format | Article |
| id | doaj.art-0fb10261676f4d0fb524ceef247d0c00 |
| institution | Directory Open Access Journal |
| issn | 1742-4933 |
| language | English |
| last_indexed | 2024-12-17T04:51:34Z |
| publishDate | 2010-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Immunity & Ageing |
| spelling | doaj.art-0fb10261676f4d0fb524ceef247d0c002022-12-21T22:02:52ZengBMCImmunity & Ageing1742-49332010-12-01711610.1186/1742-4933-7-16Alzheimer's disease gene signature says: beware of brain viral infectionsIanni ManuelaCarbone IlariaPorcellini ElisaLicastro Federico<p>Abstract</p> <p>Background</p> <p>Recent findings from a genome wide association investigation in a large cohort of patients with Alzheimer's disease (AD) and non demented controls (CTR) showed that a limited set of genes was in a strong association (p > l0<sup>-5</sup>) with the disease.</p> <p>Presentation of the hypothesis</p> <p>In this report we suggest that the polymorphism association in 8 of these genes is consistent with a non conventional interpretation of AD etiology.</p> <p>Nectin-2 (NC-2), apolipoprotein E (APOE), glycoprotein carcinoembryonic antigen related cell adhesion molecule- 16 (CEACAM-16), B-cell lymphoma-3 (Bcl-3), translocase of outer mitochondrial membrane 40 homolog (T0MM-40), complement receptor-1 (CR-l), APOJ or clusterin and C-type lectin domain A family-16 member (CLEC-16A) result in a genetic signature that might affect individual brain susceptibility to infection by herpes virus family during aging, leading to neuronal loss, inflammation and amyloid deposition.</p> <p>Implications of the hypothesis</p> <p>We hypothesized that such genetic trait may predispose to AD via complex and diverse mechanisms each contributing to an increase of individual susceptibility to brain viral infections</p>http://www.immunityageing.com/content/7/1/16 |
| spellingShingle | Ianni Manuela Carbone Ilaria Porcellini Elisa Licastro Federico Alzheimer's disease gene signature says: beware of brain viral infections Immunity & Ageing |
| title | Alzheimer's disease gene signature says: beware of brain viral infections |
| title_full | Alzheimer's disease gene signature says: beware of brain viral infections |
| title_fullStr | Alzheimer's disease gene signature says: beware of brain viral infections |
| title_full_unstemmed | Alzheimer's disease gene signature says: beware of brain viral infections |
| title_short | Alzheimer's disease gene signature says: beware of brain viral infections |
| title_sort | alzheimer s disease gene signature says beware of brain viral infections |
| url | http://www.immunityageing.com/content/7/1/16 |
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