Assessment of Mechanical/Chemical Properties and Cytotoxicity of Resin-Modified Glass Ionomer Cements Containing Sr/F-Bioactive Glass Nanoparticles and Methacrylate Functionalized Polyacids
This study prepared low-toxicity, elemental-releasing resin-modified glass ionomer cements (RMGICs). The effect of 2-hydroxyethyl methacrylate (HEMA, 0 or 5 wt%) and Sr/F-bioactive glass nanoparticles (Sr/F-BGNPs, 5 or 10 wt%) on chemical/mechanical properties and cytotoxicity were examined. Commerc...
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/12/10231 |
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| author | Wisitsin Potiprapanpong Parichart Naruphontjirakul Chutikarn Khamsuk Somruethai Channasanon Arnit Toneluck Siriporn Tanodekaew Naruporn Monmaturapoj Anne M. Young Piyaphong Panpisut |
| author_facet | Wisitsin Potiprapanpong Parichart Naruphontjirakul Chutikarn Khamsuk Somruethai Channasanon Arnit Toneluck Siriporn Tanodekaew Naruporn Monmaturapoj Anne M. Young Piyaphong Panpisut |
| author_sort | Wisitsin Potiprapanpong |
| collection | DOAJ |
| description | This study prepared low-toxicity, elemental-releasing resin-modified glass ionomer cements (RMGICs). The effect of 2-hydroxyethyl methacrylate (HEMA, 0 or 5 wt%) and Sr/F-bioactive glass nanoparticles (Sr/F-BGNPs, 5 or 10 wt%) on chemical/mechanical properties and cytotoxicity were examined. Commercial RMGIC (Vitrebond, VB) and calcium silicate cement (Theracal LC, TC) were used as comparisons. Adding HEMA and increasing Sr/F-BGNPs concentration decreased monomer conversion and enhanced elemental release but without significant effect on cytotoxicity. Rising Sr/F-BGNPs reduced the strength of the materials. The degree of monomer conversion of VB (96%) was much higher than that of the experimental RMGICs (21–51%) and TC (28%). The highest biaxial flexural strength of experimental materials (31 MPa) was significantly lower than VB (46 MPa) (<i>p</i> < 0.01) but higher than TC (24 MPa). The RMGICs with 5 wt% HEMA showed higher cumulative fluoride release (137 ppm) than VB (88 ppm) (<i>p</i> < 0.01). Unlike VB, all experimental RMGICs showed Ca, P, and Sr release. Cell viability in the presence of extracts from experimental RMGICs (89–98%) and TC (93%) was significantly higher than for VB (4%). Experimental RMGICs showed desirable physical/mechanical properties with lower toxicity than the commercial material. |
| first_indexed | 2024-03-11T02:21:01Z |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:21:01Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0fb53975e92a42d09ff1b3e6c883d56f2023-11-18T10:50:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124121023110.3390/ijms241210231Assessment of Mechanical/Chemical Properties and Cytotoxicity of Resin-Modified Glass Ionomer Cements Containing Sr/F-Bioactive Glass Nanoparticles and Methacrylate Functionalized PolyacidsWisitsin Potiprapanpong0Parichart Naruphontjirakul1Chutikarn Khamsuk2Somruethai Channasanon3Arnit Toneluck4Siriporn Tanodekaew5Naruporn Monmaturapoj6Anne M. Young7Piyaphong Panpisut8Faculty of Dentistry, Thammasat University, Pathum Thani 12120, ThailandBiological Engineering Program, Faculty of Engineering, King Mongkut’s University of Technology Thonburi, 126 Pracha Uthit Rd., Bang Mod, Thung Khru, Bangkok 10140, ThailandAssistive Technology and Medical Devices Research Center (A-MED), National Science and Technology Development Agency, Pathum Thani 12120, ThailandNational Metal and Materials Technology Center (MTEC), National Science and Technology Development Agency, Pathum Thani 12120, ThailandFaculty of Dentistry, Thammasat University, Pathum Thani 12120, ThailandNational Metal and Materials Technology Center (MTEC), National Science and Technology Development Agency, Pathum Thani 12120, ThailandAssistive Technology and Medical Devices Research Center (A-MED), National Science and Technology Development Agency, Pathum Thani 12120, ThailandDivision of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, UKFaculty of Dentistry, Thammasat University, Pathum Thani 12120, ThailandThis study prepared low-toxicity, elemental-releasing resin-modified glass ionomer cements (RMGICs). The effect of 2-hydroxyethyl methacrylate (HEMA, 0 or 5 wt%) and Sr/F-bioactive glass nanoparticles (Sr/F-BGNPs, 5 or 10 wt%) on chemical/mechanical properties and cytotoxicity were examined. Commercial RMGIC (Vitrebond, VB) and calcium silicate cement (Theracal LC, TC) were used as comparisons. Adding HEMA and increasing Sr/F-BGNPs concentration decreased monomer conversion and enhanced elemental release but without significant effect on cytotoxicity. Rising Sr/F-BGNPs reduced the strength of the materials. The degree of monomer conversion of VB (96%) was much higher than that of the experimental RMGICs (21–51%) and TC (28%). The highest biaxial flexural strength of experimental materials (31 MPa) was significantly lower than VB (46 MPa) (<i>p</i> < 0.01) but higher than TC (24 MPa). The RMGICs with 5 wt% HEMA showed higher cumulative fluoride release (137 ppm) than VB (88 ppm) (<i>p</i> < 0.01). Unlike VB, all experimental RMGICs showed Ca, P, and Sr release. Cell viability in the presence of extracts from experimental RMGICs (89–98%) and TC (93%) was significantly higher than for VB (4%). Experimental RMGICs showed desirable physical/mechanical properties with lower toxicity than the commercial material.https://www.mdpi.com/1422-0067/24/12/10231resin-modified glass ionomer cementflexural strengthpolymerizationbioactive glasscalcium phosphates |
| spellingShingle | Wisitsin Potiprapanpong Parichart Naruphontjirakul Chutikarn Khamsuk Somruethai Channasanon Arnit Toneluck Siriporn Tanodekaew Naruporn Monmaturapoj Anne M. Young Piyaphong Panpisut Assessment of Mechanical/Chemical Properties and Cytotoxicity of Resin-Modified Glass Ionomer Cements Containing Sr/F-Bioactive Glass Nanoparticles and Methacrylate Functionalized Polyacids International Journal of Molecular Sciences resin-modified glass ionomer cement flexural strength polymerization bioactive glass calcium phosphates |
| title | Assessment of Mechanical/Chemical Properties and Cytotoxicity of Resin-Modified Glass Ionomer Cements Containing Sr/F-Bioactive Glass Nanoparticles and Methacrylate Functionalized Polyacids |
| title_full | Assessment of Mechanical/Chemical Properties and Cytotoxicity of Resin-Modified Glass Ionomer Cements Containing Sr/F-Bioactive Glass Nanoparticles and Methacrylate Functionalized Polyacids |
| title_fullStr | Assessment of Mechanical/Chemical Properties and Cytotoxicity of Resin-Modified Glass Ionomer Cements Containing Sr/F-Bioactive Glass Nanoparticles and Methacrylate Functionalized Polyacids |
| title_full_unstemmed | Assessment of Mechanical/Chemical Properties and Cytotoxicity of Resin-Modified Glass Ionomer Cements Containing Sr/F-Bioactive Glass Nanoparticles and Methacrylate Functionalized Polyacids |
| title_short | Assessment of Mechanical/Chemical Properties and Cytotoxicity of Resin-Modified Glass Ionomer Cements Containing Sr/F-Bioactive Glass Nanoparticles and Methacrylate Functionalized Polyacids |
| title_sort | assessment of mechanical chemical properties and cytotoxicity of resin modified glass ionomer cements containing sr f bioactive glass nanoparticles and methacrylate functionalized polyacids |
| topic | resin-modified glass ionomer cement flexural strength polymerization bioactive glass calcium phosphates |
| url | https://www.mdpi.com/1422-0067/24/12/10231 |
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