Possible Metastatic Stage-Dependent ILC2 Activation Induces Differential Functions of MDSCs through IL-13/IL-13Rα1 Signaling during the Progression of Breast Cancer Lung Metastasis

Possible Metastatic Stage-Dependent ILC2 Activation Induces Differential Functions of MDSCs through IL-13/IL-13Rα1 Signaling during the Progression of Breast Cancer Lung Metastasis

Breast cancer is the most common cancer in women worldwide, and lung metastasis is one of the most frequent distant metastases. When breast cancer metastasizes to the lung, group 2 innate lymphoid cells (ILC2s) are thought to promote tumor growth via the activation of myeloid-derived suppressor cell...

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Bibliographic Details
Main Authors: Atsushi Ito, Yuichi Akama, Naoko Satoh-Takayama, Kanako Saito, Takuma Kato, Eiji Kawamoto, Arong Gaowa, Eun Jeong Park, Motoshi Takao, Motomu Shimaoka
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
group 2 innate lymphoid cells
breast cancer
lung metastasis
micro- and macrometastasis
tumor microenvironment
myeloid-derived suppressor cells
Online Access:https://www.mdpi.com/2072-6694/14/13/3267

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