Fatty-Acid-Rich <i>Agave angustifolia</i> Fraction Shows Antiarthritic and Immunomodulatory Effect
<i>Agave angustifolia</i> is a xerophytic species widely used in Mexico as an ingredient in sweet food and fermented beverages; it is also used in traditional medicine to treat wound pain and rheumatic damage, and as a remedy for psoriasis. Among the various <i>A. angustifolia</...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/21/7204 |
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| author | Enrique Jiménez-Ferrer Gabriela Vargas-Villa Gabriela Belen Martínez-Hernández Manases González-Cortazar Alejandro Zamilpa Maribel Patricia García-Aguilar Martha Lucía Arenas-Ocampo Maribel Herrera-Ruiz |
| author_facet | Enrique Jiménez-Ferrer Gabriela Vargas-Villa Gabriela Belen Martínez-Hernández Manases González-Cortazar Alejandro Zamilpa Maribel Patricia García-Aguilar Martha Lucía Arenas-Ocampo Maribel Herrera-Ruiz |
| author_sort | Enrique Jiménez-Ferrer |
| collection | DOAJ |
| description | <i>Agave angustifolia</i> is a xerophytic species widely used in Mexico as an ingredient in sweet food and fermented beverages; it is also used in traditional medicine to treat wound pain and rheumatic damage, and as a remedy for psoriasis. Among the various <i>A. angustifolia</i> extracts and extract fractions that have been evaluated for their anti-inflammatory effects, the acetonic extract (AaAc) and its acetonic (F-Ac) and methanolic (F-MeOH) fractions were the most active in a xylene-induced ear edema model in mice, when orally administered. Four fractions resulting from chemically resolving F-Ac (F1–F4) were locally applied to mice with phorbol 12-myristate 13-acetate (TPA)-induced ear inflammation; F1 inhibited inflammation by 70% and was further evaluated in a carrageenan-induced mono-arthritis model. When administered at doses of 12.5, 25, and 50 mg/kg, F1 reduced articular edema and the spleen index. In addition, it modulated spleen and joint cytokine levels and decreased pain. According to a GC–MS analysis, the main components of F1 are fatty-acid derivatives: palmitic acid methyl ester, palmitic acid ethyl ester, octadecenoic acid methyl ester, linoleic acid ethyl ester, and oleic acid ethyl ester. |
| first_indexed | 2024-03-09T18:48:35Z |
| format | Article |
| id | doaj.art-0fb8a48cc34f4a42b43721ccfe3c0813 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:48:35Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-0fb8a48cc34f4a42b43721ccfe3c08132023-11-24T06:00:20ZengMDPI AGMolecules1420-30492022-10-012721720410.3390/molecules27217204Fatty-Acid-Rich <i>Agave angustifolia</i> Fraction Shows Antiarthritic and Immunomodulatory EffectEnrique Jiménez-Ferrer0Gabriela Vargas-Villa1Gabriela Belen Martínez-Hernández2Manases González-Cortazar3Alejandro Zamilpa4Maribel Patricia García-Aguilar5Martha Lucía Arenas-Ocampo6Maribel Herrera-Ruiz7Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, MexicoCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, MexicoCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, MexicoCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, MexicoCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, MexicoCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, MexicoCentro de Desarrollo de Productos Bióticos, Instituto Politécnico Nacional, Col. San Isidro, Yautepec 62739, Morelos, MexicoCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico<i>Agave angustifolia</i> is a xerophytic species widely used in Mexico as an ingredient in sweet food and fermented beverages; it is also used in traditional medicine to treat wound pain and rheumatic damage, and as a remedy for psoriasis. Among the various <i>A. angustifolia</i> extracts and extract fractions that have been evaluated for their anti-inflammatory effects, the acetonic extract (AaAc) and its acetonic (F-Ac) and methanolic (F-MeOH) fractions were the most active in a xylene-induced ear edema model in mice, when orally administered. Four fractions resulting from chemically resolving F-Ac (F1–F4) were locally applied to mice with phorbol 12-myristate 13-acetate (TPA)-induced ear inflammation; F1 inhibited inflammation by 70% and was further evaluated in a carrageenan-induced mono-arthritis model. When administered at doses of 12.5, 25, and 50 mg/kg, F1 reduced articular edema and the spleen index. In addition, it modulated spleen and joint cytokine levels and decreased pain. According to a GC–MS analysis, the main components of F1 are fatty-acid derivatives: palmitic acid methyl ester, palmitic acid ethyl ester, octadecenoic acid methyl ester, linoleic acid ethyl ester, and oleic acid ethyl ester.https://www.mdpi.com/1420-3049/27/21/7204<i>Agave angustifolia</i>edible plantfatty acidsrheumatoid arthritispaininflammation |
| spellingShingle | Enrique Jiménez-Ferrer Gabriela Vargas-Villa Gabriela Belen Martínez-Hernández Manases González-Cortazar Alejandro Zamilpa Maribel Patricia García-Aguilar Martha Lucía Arenas-Ocampo Maribel Herrera-Ruiz Fatty-Acid-Rich <i>Agave angustifolia</i> Fraction Shows Antiarthritic and Immunomodulatory Effect Molecules <i>Agave angustifolia</i> edible plant fatty acids rheumatoid arthritis pain inflammation |
| title | Fatty-Acid-Rich <i>Agave angustifolia</i> Fraction Shows Antiarthritic and Immunomodulatory Effect |
| title_full | Fatty-Acid-Rich <i>Agave angustifolia</i> Fraction Shows Antiarthritic and Immunomodulatory Effect |
| title_fullStr | Fatty-Acid-Rich <i>Agave angustifolia</i> Fraction Shows Antiarthritic and Immunomodulatory Effect |
| title_full_unstemmed | Fatty-Acid-Rich <i>Agave angustifolia</i> Fraction Shows Antiarthritic and Immunomodulatory Effect |
| title_short | Fatty-Acid-Rich <i>Agave angustifolia</i> Fraction Shows Antiarthritic and Immunomodulatory Effect |
| title_sort | fatty acid rich i agave angustifolia i fraction shows antiarthritic and immunomodulatory effect |
| topic | <i>Agave angustifolia</i> edible plant fatty acids rheumatoid arthritis pain inflammation |
| url | https://www.mdpi.com/1420-3049/27/21/7204 |
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