Sialic Acid-Siglec-E Interactions During Pseudomonas aeruginosa Infection of Macrophages Interferes With Phagosome Maturation by Altering Intracellular Calcium Concentrations

Sialic Acid-Siglec-E Interactions During Pseudomonas aeruginosa Infection of Macrophages Interferes With Phagosome Maturation by Altering Intracellular Calcium Concentrations

Pseudomonas aeruginosa (PA) is commonly associated with nosocomial and chronic infections of lungs. We have earlier demonstrated that an acidic sugar, sialic acid, is present in PA which is recognized and bound by sialic acid binding immunoglobulin type lectins (siglecs) expressed on neutrophils. He...

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Bibliographic Details
Main Authors: Kaustuv Mukherjee, Biswajit Khatua, Chitra Mandal
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
Pseudomonas aeruginosa
sialic acids
sialic acid-binding immunoglobulin-like lectins (siglecs)
siglec-E
macrophage
calcium
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00332/full

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