Hematological Prognostic Scoring System Can Predict Overall Survival and Can Indicate Response to Immunotherapy in Patients With Osteosarcoma
Osteosarcoma is the most common primary malignant bone tumor with a high metastatic potential. Nowadays, there is a lack of new markers to identify prognosis of osteosarcoma patients with response to medical treatment. Recent studies have shown that hematological markers can reflect to some extent t...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.879560/full |
| _version_ | 1818268950017867776 |
|---|---|
| author | Longqing Li Longqing Li Yang Wang Yang Wang Xuanhong He Xuanhong He Zhuangzhuang Li Zhuangzhuang Li Minxun Lu Minxun Lu Taojun Gong Taojun Gong Qing Chang Jingqi Lin Chuang Liu Yi Luo Yi Luo Li Min Li Min Yong Zhou Yong Zhou Chongqi Tu Chongqi Tu |
| author_facet | Longqing Li Longqing Li Yang Wang Yang Wang Xuanhong He Xuanhong He Zhuangzhuang Li Zhuangzhuang Li Minxun Lu Minxun Lu Taojun Gong Taojun Gong Qing Chang Jingqi Lin Chuang Liu Yi Luo Yi Luo Li Min Li Min Yong Zhou Yong Zhou Chongqi Tu Chongqi Tu |
| author_sort | Longqing Li |
| collection | DOAJ |
| description | Osteosarcoma is the most common primary malignant bone tumor with a high metastatic potential. Nowadays, there is a lack of new markers to identify prognosis of osteosarcoma patients with response to medical treatment. Recent studies have shown that hematological markers can reflect to some extent the microenvironment of an individual with the potential to predict patient prognosis. However, most of the previous studies have studied the prognostic value of a single hematological index, and it is difficult to comprehensively reflect the tumor microenvironment of patients. Here, we comprehensively collected 16 hematological markers and constructed a hematological prognostic scoring system (HPSS) using LASSO cox regression analysis. HPSS contains many indicators such as immunity, inflammation, coagulation and nutrition. Our results suggest that HPSS is an independent prognostic factor for overall survival in osteosarcoma patients and is an optimal addition to clinical characteristics and well suited to further identify high-risk patients from clinically low-risk patients. HPSS-based nomograms have good predictive ability. Finally, HPSS also has some hints for immunotherapy response in osteosarcoma patients. |
| first_indexed | 2024-12-12T20:46:37Z |
| format | Article |
| id | doaj.art-0fbac1b6c95e46f5976343e11578b01a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T20:46:37Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0fbac1b6c95e46f5976343e11578b01a2022-12-22T00:12:34ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-05-011310.3389/fimmu.2022.879560879560Hematological Prognostic Scoring System Can Predict Overall Survival and Can Indicate Response to Immunotherapy in Patients With OsteosarcomaLongqing Li0Longqing Li1Yang Wang2Yang Wang3Xuanhong He4Xuanhong He5Zhuangzhuang Li6Zhuangzhuang Li7Minxun Lu8Minxun Lu9Taojun Gong10Taojun Gong11Qing Chang12Jingqi Lin13Chuang Liu14Yi Luo15Yi Luo16Li Min17Li Min18Yong Zhou19Yong Zhou20Chongqi Tu21Chongqi Tu22Department of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaBone and Joint 3D-Printing and Biomechanical Laboratory, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaBone and Joint 3D-Printing and Biomechanical Laboratory, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaBone and Joint 3D-Printing and Biomechanical Laboratory, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaBone and Joint 3D-Printing and Biomechanical Laboratory, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaBone and Joint 3D-Printing and Biomechanical Laboratory, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaBone and Joint 3D-Printing and Biomechanical Laboratory, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Jinan Yinfeng Medical Laboratory, Yinfeng Gene Technology Co Ltd, Jinan, ChinaDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaBone and Joint 3D-Printing and Biomechanical Laboratory, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaBone and Joint 3D-Printing and Biomechanical Laboratory, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaBone and Joint 3D-Printing and Biomechanical Laboratory, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaBone and Joint 3D-Printing and Biomechanical Laboratory, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, ChinaOsteosarcoma is the most common primary malignant bone tumor with a high metastatic potential. Nowadays, there is a lack of new markers to identify prognosis of osteosarcoma patients with response to medical treatment. Recent studies have shown that hematological markers can reflect to some extent the microenvironment of an individual with the potential to predict patient prognosis. However, most of the previous studies have studied the prognostic value of a single hematological index, and it is difficult to comprehensively reflect the tumor microenvironment of patients. Here, we comprehensively collected 16 hematological markers and constructed a hematological prognostic scoring system (HPSS) using LASSO cox regression analysis. HPSS contains many indicators such as immunity, inflammation, coagulation and nutrition. Our results suggest that HPSS is an independent prognostic factor for overall survival in osteosarcoma patients and is an optimal addition to clinical characteristics and well suited to further identify high-risk patients from clinically low-risk patients. HPSS-based nomograms have good predictive ability. Finally, HPSS also has some hints for immunotherapy response in osteosarcoma patients.https://www.frontiersin.org/articles/10.3389/fimmu.2022.879560/fullosteosarcomahematologicalprognosticinflammationimmunotherapy |
| spellingShingle | Longqing Li Longqing Li Yang Wang Yang Wang Xuanhong He Xuanhong He Zhuangzhuang Li Zhuangzhuang Li Minxun Lu Minxun Lu Taojun Gong Taojun Gong Qing Chang Jingqi Lin Chuang Liu Yi Luo Yi Luo Li Min Li Min Yong Zhou Yong Zhou Chongqi Tu Chongqi Tu Hematological Prognostic Scoring System Can Predict Overall Survival and Can Indicate Response to Immunotherapy in Patients With Osteosarcoma Frontiers in Immunology osteosarcoma hematological prognostic inflammation immunotherapy |
| title | Hematological Prognostic Scoring System Can Predict Overall Survival and Can Indicate Response to Immunotherapy in Patients With Osteosarcoma |
| title_full | Hematological Prognostic Scoring System Can Predict Overall Survival and Can Indicate Response to Immunotherapy in Patients With Osteosarcoma |
| title_fullStr | Hematological Prognostic Scoring System Can Predict Overall Survival and Can Indicate Response to Immunotherapy in Patients With Osteosarcoma |
| title_full_unstemmed | Hematological Prognostic Scoring System Can Predict Overall Survival and Can Indicate Response to Immunotherapy in Patients With Osteosarcoma |
| title_short | Hematological Prognostic Scoring System Can Predict Overall Survival and Can Indicate Response to Immunotherapy in Patients With Osteosarcoma |
| title_sort | hematological prognostic scoring system can predict overall survival and can indicate response to immunotherapy in patients with osteosarcoma |
| topic | osteosarcoma hematological prognostic inflammation immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.879560/full |
| work_keys_str_mv | AT longqingli hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT longqingli hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT yangwang hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT yangwang hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT xuanhonghe hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT xuanhonghe hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT zhuangzhuangli hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT zhuangzhuangli hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT minxunlu hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT minxunlu hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT taojungong hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT taojungong hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT qingchang hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT jingqilin hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT chuangliu hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT yiluo hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT yiluo hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT limin hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT limin hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT yongzhou hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT yongzhou hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT chongqitu hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma AT chongqitu hematologicalprognosticscoringsystemcanpredictoverallsurvivalandcanindicateresponsetoimmunotherapyinpatientswithosteosarcoma |