The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies
Recent evidence demonstrates an involvement of impaired mitochondrial function in peripheral arterial disease (PAD) development. Specific impairments have been assessed by different methodological in-vivo (near-infrared spectroscopy, <sup>31</sup>P magnetic resonance spectroscopy), as we...
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MDPI AG
2021-08-01
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Online Access: | https://www.mdpi.com/1422-0067/22/16/8478 |
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author | Alexandra Gratl Sabine Wipper Jan Paul Frese Ben Raude Andreas Greiner Dominik Pesta |
author_facet | Alexandra Gratl Sabine Wipper Jan Paul Frese Ben Raude Andreas Greiner Dominik Pesta |
author_sort | Alexandra Gratl |
collection | DOAJ |
description | Recent evidence demonstrates an involvement of impaired mitochondrial function in peripheral arterial disease (PAD) development. Specific impairments have been assessed by different methodological in-vivo (near-infrared spectroscopy, <sup>31</sup>P magnetic resonance spectroscopy), as well as in-vitro approaches (Western blotting of mitochondrial proteins and enzymes, assays of mitochondrial function and content). While effects differ with regard to disease severity, chronic malperfusion impacts subcellular energy homeostasis, and repeating cycles of ischemia and reperfusion contribute to PAD disease progression by increasing mitochondrial reactive oxygen species production and impairing mitochondrial function. With the leading clinical symptom of decreased walking capacity due to intermittent claudication, PAD patients suffer from a subsequent reduction of quality of life. Different treatment modalities, such as physical activity and revascularization procedures, can aid mitochondrial recovery. While the relevance of these modalities for mitochondrial functional recovery is still a matter of debate, recent research indicates the importance of revascularization procedures, with increased physical activity levels being a subordinate contributor, at least during mild stages of PAD. With an additional focus on the role of revascularization procedures on mitochondria and the identification of suitable mitochondrial markers in PAD, this review aims to critically evaluate the relevance of mitochondrial function in PAD development and progression. |
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issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-10T08:45:29Z |
publishDate | 2021-08-01 |
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spelling | doaj.art-0fbbc5c5cab54140bf79c89e7e67d4662023-11-22T07:55:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012216847810.3390/ijms22168478The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational StudiesAlexandra Gratl0Sabine Wipper1Jan Paul Frese2Ben Raude3Andreas Greiner4Dominik Pesta5Department of Vascular Surgery, Medical University of Innsbruck, A-6020 Innsbruck, AustriaDepartment of Vascular Surgery, Medical University of Innsbruck, A-6020 Innsbruck, AustriaDepartment of Vascular Surgery, Charité—University Hospital of Berlin, D-12203 Berlin, GermanyDepartment of Vascular Surgery, Charité—University Hospital of Berlin, D-12203 Berlin, GermanyDepartment of Vascular Surgery, Charité—University Hospital of Berlin, D-12203 Berlin, GermanyGerman Aerospace Center (DLR), Institute of Aerospace Medicine, D-51147 Cologne, GermanyRecent evidence demonstrates an involvement of impaired mitochondrial function in peripheral arterial disease (PAD) development. Specific impairments have been assessed by different methodological in-vivo (near-infrared spectroscopy, <sup>31</sup>P magnetic resonance spectroscopy), as well as in-vitro approaches (Western blotting of mitochondrial proteins and enzymes, assays of mitochondrial function and content). While effects differ with regard to disease severity, chronic malperfusion impacts subcellular energy homeostasis, and repeating cycles of ischemia and reperfusion contribute to PAD disease progression by increasing mitochondrial reactive oxygen species production and impairing mitochondrial function. With the leading clinical symptom of decreased walking capacity due to intermittent claudication, PAD patients suffer from a subsequent reduction of quality of life. Different treatment modalities, such as physical activity and revascularization procedures, can aid mitochondrial recovery. While the relevance of these modalities for mitochondrial functional recovery is still a matter of debate, recent research indicates the importance of revascularization procedures, with increased physical activity levels being a subordinate contributor, at least during mild stages of PAD. With an additional focus on the role of revascularization procedures on mitochondria and the identification of suitable mitochondrial markers in PAD, this review aims to critically evaluate the relevance of mitochondrial function in PAD development and progression.https://www.mdpi.com/1422-0067/22/16/8478mitochondrial functionperipheral arterial diseasephysical activitymitochondrial recoveryrevascularization |
spellingShingle | Alexandra Gratl Sabine Wipper Jan Paul Frese Ben Raude Andreas Greiner Dominik Pesta The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies International Journal of Molecular Sciences mitochondrial function peripheral arterial disease physical activity mitochondrial recovery revascularization |
title | The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies |
title_full | The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies |
title_fullStr | The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies |
title_full_unstemmed | The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies |
title_short | The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies |
title_sort | role of mitochondrial function in peripheral arterial disease insights from translational studies |
topic | mitochondrial function peripheral arterial disease physical activity mitochondrial recovery revascularization |
url | https://www.mdpi.com/1422-0067/22/16/8478 |
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