Anti-Inflammatory and Immunomodulatory Effect of High-Dose Immunoglobulins in Children: From Approved Indications to Off-Label Use

Anti-Inflammatory and Immunomodulatory Effect of High-Dose Immunoglobulins in Children: From Approved Indications to Off-Label Use

Background: The large-scale utilization of immunoglobulins in patients with inborn errors of immunity (IEIs) since 1952 prompted the discovery of their key role at high doses as immunomodulatory and anti-inflammatory therapy, in the treatment of IEI-related immune dysregulation disorders, according...

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Bibliographic Details
Main Authors: Francesca Conti, Mattia Moratti, Lucia Leonardi, Arianna Catelli, Elisa Bortolamedi, Emanuele Filice, Anna Fetta, Marianna Fabi, Elena Facchini, Maria Elena Cantarini, Angela Miniaci, Duccio Maria Cordelli, Marcello Lanari, Andrea Pession, Daniele Zama
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
anti-inflammatory
children
high dose immunoglobulin
immune dysregulation
immunomodulation
immunomodulatory
Online Access:https://www.mdpi.com/2073-4409/12/19/2417

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