Bridging the Chemical Profiles and Biological Effects of <i>Spathodea campanulat</i><i>a</i> Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves
<i>Spathodea campanulata</i> is an important medicinal plant with traditional uses in the tropical zone. In the current work, we aimed to determine the chemical profiles and biological effects of extracts (methanolic and infusion (water)) from the leaves and stem bark of <i>S. camp...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/15/4694 |
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| author | Łukasz Świątek Elwira Sieniawska Kouadio Ibrahime Sinan Gokhan Zengin Abdullahi Ibrahim Uba Kouadio Bene Magdalena Maciejewska-Turska Barbara Rajtar Małgorzata Polz-Dacewicz Abdurrahman Aktumsek |
| author_facet | Łukasz Świątek Elwira Sieniawska Kouadio Ibrahime Sinan Gokhan Zengin Abdullahi Ibrahim Uba Kouadio Bene Magdalena Maciejewska-Turska Barbara Rajtar Małgorzata Polz-Dacewicz Abdurrahman Aktumsek |
| author_sort | Łukasz Świątek |
| collection | DOAJ |
| description | <i>Spathodea campanulata</i> is an important medicinal plant with traditional uses in the tropical zone. In the current work, we aimed to determine the chemical profiles and biological effects of extracts (methanolic and infusion (water)) from the leaves and stem bark of <i>S. campanulata</i>. The chemical components of the tested extracts were identified using LC-ESI-QTOF-MS. Biological effects were tested in terms of antioxidant (radical scavenging, reducing power, and metal chelating), enzyme inhibitory (cholinesterase, amylase, glucosidase, and tyrosinase), antineoplastic, and antiviral activities. Fifty-seven components were identified in the tested extracts, including iridoids, flavonoids, and phenolic acids as the main constituents. In general, the leaves-MeOH extract was the most active in the antioxidant assays (DPPH, ABTS, CUPRAC, FRAP, metal chelating, and phosphomolybdenum). Antineoplastic effects were tested in normal (VERO cell line) and cancer cell lines (FaDu, HeLa, and RKO). The leaf infusion, as well as the extracts obtained from stem bark, showed antineoplastic activity (CC<sub>50</sub> 119.03–222.07 µg/mL). Antiviral effects were tested against HHV-1 and CVB3, and the leaf methanolic extract (500 µg/mL) exerted antiviral activity towards HHV-1, inhibiting the viral-induced cytopathic effect and reducing the viral infectious titre by 5.11 log and viral load by 1.45 log. In addition, molecular docking was performed to understand the interactions between selected chemical components and viral targets (HSV-1 DNA polymerase, HSV-1 protease, and HSV-1 thymidine kinase). The results presented suggest that <i>S. campanulata</i> may be a bright spot in moving from natural sources to industrial applications, including novel drugs, cosmeceuticals, and nutraceuticals. |
| first_indexed | 2024-03-09T12:21:28Z |
| format | Article |
| id | doaj.art-0fbe95205db04dacbedfc566065a7660 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T12:21:28Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-0fbe95205db04dacbedfc566065a76602023-11-30T22:39:25ZengMDPI AGMolecules1420-30492022-07-012715469410.3390/molecules27154694Bridging the Chemical Profiles and Biological Effects of <i>Spathodea campanulat</i><i>a</i> Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy ShelvesŁukasz Świątek0Elwira Sieniawska1Kouadio Ibrahime Sinan2Gokhan Zengin3Abdullahi Ibrahim Uba4Kouadio Bene5Magdalena Maciejewska-Turska6Barbara Rajtar7Małgorzata Polz-Dacewicz8Abdurrahman Aktumsek9Department of Virology with SARS Laboratory, Medical University of Lublin, Chodzki 1, 20-093 Lublin, PolandDepartment of Natural Products Chemistry, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Biology, Science Faculty, Selcuk University, 42130 Konya, TurkeyDepartment of Biology, Science Faculty, Selcuk University, 42130 Konya, TurkeyDepartment of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Kadir Has University, Istanbul 34083, TurkeyLaboratoire de Botanique et Phytothérapie, Unité de Formation et de Recherche Sciences de la Nature, Université Nangui Abrogoua, Abidjan 00225, Côte d’IvoireDepartment of Pharmacognosy with Medicinal Plant Garden, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Virology with SARS Laboratory, Medical University of Lublin, Chodzki 1, 20-093 Lublin, PolandDepartment of Virology with SARS Laboratory, Medical University of Lublin, Chodzki 1, 20-093 Lublin, PolandDepartment of Biology, Science Faculty, Selcuk University, 42130 Konya, Turkey<i>Spathodea campanulata</i> is an important medicinal plant with traditional uses in the tropical zone. In the current work, we aimed to determine the chemical profiles and biological effects of extracts (methanolic and infusion (water)) from the leaves and stem bark of <i>S. campanulata</i>. The chemical components of the tested extracts were identified using LC-ESI-QTOF-MS. Biological effects were tested in terms of antioxidant (radical scavenging, reducing power, and metal chelating), enzyme inhibitory (cholinesterase, amylase, glucosidase, and tyrosinase), antineoplastic, and antiviral activities. Fifty-seven components were identified in the tested extracts, including iridoids, flavonoids, and phenolic acids as the main constituents. In general, the leaves-MeOH extract was the most active in the antioxidant assays (DPPH, ABTS, CUPRAC, FRAP, metal chelating, and phosphomolybdenum). Antineoplastic effects were tested in normal (VERO cell line) and cancer cell lines (FaDu, HeLa, and RKO). The leaf infusion, as well as the extracts obtained from stem bark, showed antineoplastic activity (CC<sub>50</sub> 119.03–222.07 µg/mL). Antiviral effects were tested against HHV-1 and CVB3, and the leaf methanolic extract (500 µg/mL) exerted antiviral activity towards HHV-1, inhibiting the viral-induced cytopathic effect and reducing the viral infectious titre by 5.11 log and viral load by 1.45 log. In addition, molecular docking was performed to understand the interactions between selected chemical components and viral targets (HSV-1 DNA polymerase, HSV-1 protease, and HSV-1 thymidine kinase). The results presented suggest that <i>S. campanulata</i> may be a bright spot in moving from natural sources to industrial applications, including novel drugs, cosmeceuticals, and nutraceuticals.https://www.mdpi.com/1420-3049/27/15/4694<i>Spathodea campanulata</i>antioxidantsantineoplasticantiviraliridoidsbioactive agents |
| spellingShingle | Łukasz Świątek Elwira Sieniawska Kouadio Ibrahime Sinan Gokhan Zengin Abdullahi Ibrahim Uba Kouadio Bene Magdalena Maciejewska-Turska Barbara Rajtar Małgorzata Polz-Dacewicz Abdurrahman Aktumsek Bridging the Chemical Profiles and Biological Effects of <i>Spathodea campanulat</i><i>a</i> Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves Molecules <i>Spathodea campanulata</i> antioxidants antineoplastic antiviral iridoids bioactive agents |
| title | Bridging the Chemical Profiles and Biological Effects of <i>Spathodea campanulat</i><i>a</i> Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves |
| title_full | Bridging the Chemical Profiles and Biological Effects of <i>Spathodea campanulat</i><i>a</i> Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves |
| title_fullStr | Bridging the Chemical Profiles and Biological Effects of <i>Spathodea campanulat</i><i>a</i> Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves |
| title_full_unstemmed | Bridging the Chemical Profiles and Biological Effects of <i>Spathodea campanulat</i><i>a</i> Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves |
| title_short | Bridging the Chemical Profiles and Biological Effects of <i>Spathodea campanulat</i><i>a</i> Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves |
| title_sort | bridging the chemical profiles and biological effects of i spathodea campanulat i i a i extracts a new contribution on the road from natural treasure to pharmacy shelves |
| topic | <i>Spathodea campanulata</i> antioxidants antineoplastic antiviral iridoids bioactive agents |
| url | https://www.mdpi.com/1420-3049/27/15/4694 |
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