Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine
We investigated the rapid and sustained antidepressant effects of enantiomers of ketamine in N-methyl-d-aspartate (NMDA) receptor GluN2D subunit knockout (GluN2D-KO) mice. Intraperitoneal administration of ketamine or its enantiomers 10 min before the tail-suspension test exerted significant antidep...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-11-01
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| Series: | Journal of Pharmacological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S134786131730186X |
| _version_ | 1819231631597109248 |
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| author | Soichiro Ide Yuiko Ikekubo Masayoshi Mishina Kenji Hashimoto Kazutaka Ikeda |
| author_facet | Soichiro Ide Yuiko Ikekubo Masayoshi Mishina Kenji Hashimoto Kazutaka Ikeda |
| author_sort | Soichiro Ide |
| collection | DOAJ |
| description | We investigated the rapid and sustained antidepressant effects of enantiomers of ketamine in N-methyl-d-aspartate (NMDA) receptor GluN2D subunit knockout (GluN2D-KO) mice. Intraperitoneal administration of ketamine or its enantiomers 10 min before the tail-suspension test exerted significant antidepressant effects on restraint stress-induced depression in both wildtype and GluN2D-KO mice. The antidepressant effects of (RS)-ketamine and (S)-ketamine were sustained 96 h after the injection in both wildtype and GluN2D-KO mice, but such sustained antidepressant effects of (R)-ketamine were only observed in wildtype mice. These data suggest that the GluN2D subunit is critical for the sustained antidepressant effects of (R)-ketamine. |
| first_indexed | 2024-12-23T11:48:02Z |
| format | Article |
| id | doaj.art-0fc0a8cb963c44c3938dbe348a6d5fc7 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-23T11:48:02Z |
| publishDate | 2017-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-0fc0a8cb963c44c3938dbe348a6d5fc72022-12-21T17:48:17ZengElsevierJournal of Pharmacological Sciences1347-86132017-11-01135313814010.1016/j.jphs.2017.11.001Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamineSoichiro Ide0Yuiko Ikekubo1Masayoshi Mishina2Kenji Hashimoto3Kazutaka Ikeda4Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, JapanAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, JapanBrain Science Laboratory, The Research Organization of Science and Technology, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, JapanCenter for Forensic Mental Health, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, JapanAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, JapanWe investigated the rapid and sustained antidepressant effects of enantiomers of ketamine in N-methyl-d-aspartate (NMDA) receptor GluN2D subunit knockout (GluN2D-KO) mice. Intraperitoneal administration of ketamine or its enantiomers 10 min before the tail-suspension test exerted significant antidepressant effects on restraint stress-induced depression in both wildtype and GluN2D-KO mice. The antidepressant effects of (RS)-ketamine and (S)-ketamine were sustained 96 h after the injection in both wildtype and GluN2D-KO mice, but such sustained antidepressant effects of (R)-ketamine were only observed in wildtype mice. These data suggest that the GluN2D subunit is critical for the sustained antidepressant effects of (R)-ketamine.http://www.sciencedirect.com/science/article/pii/S134786131730186XKetamineDepressionGluN2D |
| spellingShingle | Soichiro Ide Yuiko Ikekubo Masayoshi Mishina Kenji Hashimoto Kazutaka Ikeda Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine Journal of Pharmacological Sciences Ketamine Depression GluN2D |
| title | Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine |
| title_full | Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine |
| title_fullStr | Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine |
| title_full_unstemmed | Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine |
| title_short | Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine |
| title_sort | role of nmda receptor glun2d subunit in the antidepressant effects of enantiomers of ketamine |
| topic | Ketamine Depression GluN2D |
| url | http://www.sciencedirect.com/science/article/pii/S134786131730186X |
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