Cerebral Diseases in Liver Transplant Recipients: Systematic Review of Clinical Evidence
This systematic review presents clinical evidence on early and long-term cerebral diseases in liver transplant recipients. The literature search led to the retrieval of 12 relevant studies. Early postoperative cerebral complications include intracranial hemorrhage associated with a coexisting coagul...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/4/979 |
| _version_ | 1797479091860930560 |
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| author | Paula Dudek Paweł Andruszkiewicz Remigiusz Gelo Rafael Badenes Federico Bilotta |
| author_facet | Paula Dudek Paweł Andruszkiewicz Remigiusz Gelo Rafael Badenes Federico Bilotta |
| author_sort | Paula Dudek |
| collection | DOAJ |
| description | This systematic review presents clinical evidence on early and long-term cerebral diseases in liver transplant recipients. The literature search led to the retrieval of 12 relevant studies. Early postoperative cerebral complications include intracranial hemorrhage associated with a coexisting coagulopathy, perioperative hypertension, and higher MELD scores and is more frequent in critically ill recipients; central pontine and extrapontine myelinolysis are associated with notable perioperative changes in the plasma Na+ concentration and massive transfusion. Long-term follow-up cerebral complications include focal brain lesions, cerebrovascular diseases, and posterior reversible encephalopathy; there is no proven relationship between the toxicity immunosuppressive drugs and cerebral complications. This SR confirms a very low incidence of opportunistic cerebral infections. |
| first_indexed | 2024-03-09T21:41:29Z |
| format | Article |
| id | doaj.art-0fc1c9ed7c814dd1a1c3a3202d458a94 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T21:41:29Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0fc1c9ed7c814dd1a1c3a3202d458a942023-11-23T20:29:50ZengMDPI AGJournal of Clinical Medicine2077-03832022-02-0111497910.3390/jcm11040979Cerebral Diseases in Liver Transplant Recipients: Systematic Review of Clinical EvidencePaula Dudek0Paweł Andruszkiewicz1Remigiusz Gelo2Rafael Badenes3Federico Bilotta42nd Department of Anesthesiology and Intensive Care, Medical University of Warsaw, 02-097 Warsaw, Poland2nd Department of Anesthesiology and Intensive Care, Medical University of Warsaw, 02-097 Warsaw, Poland2nd Department of Anesthesiology and Intensive Care, Medical University of Warsaw, 02-097 Warsaw, PolandDepartment of Anesthesiology and Surgical-Trauma Intensive Care, Hospital Clínic Universitari de Valencia, University of Valencia, 46010 Valencia, SpainDepartment of Emergency Medicine, Anesthesiology and Intensive Care, Policlinico Umberto I, “Sapienza” University of Rome, 00161 Rome, ItalyThis systematic review presents clinical evidence on early and long-term cerebral diseases in liver transplant recipients. The literature search led to the retrieval of 12 relevant studies. Early postoperative cerebral complications include intracranial hemorrhage associated with a coexisting coagulopathy, perioperative hypertension, and higher MELD scores and is more frequent in critically ill recipients; central pontine and extrapontine myelinolysis are associated with notable perioperative changes in the plasma Na+ concentration and massive transfusion. Long-term follow-up cerebral complications include focal brain lesions, cerebrovascular diseases, and posterior reversible encephalopathy; there is no proven relationship between the toxicity immunosuppressive drugs and cerebral complications. This SR confirms a very low incidence of opportunistic cerebral infections.https://www.mdpi.com/2077-0383/11/4/979liver transplantationearly postoperative complicationslong-term follow-up complicationspostoperative neurological complicationsintracranial hemorrhagepostoperative cerebral infection after liver transplant |
| spellingShingle | Paula Dudek Paweł Andruszkiewicz Remigiusz Gelo Rafael Badenes Federico Bilotta Cerebral Diseases in Liver Transplant Recipients: Systematic Review of Clinical Evidence Journal of Clinical Medicine liver transplantation early postoperative complications long-term follow-up complications postoperative neurological complications intracranial hemorrhage postoperative cerebral infection after liver transplant |
| title | Cerebral Diseases in Liver Transplant Recipients: Systematic Review of Clinical Evidence |
| title_full | Cerebral Diseases in Liver Transplant Recipients: Systematic Review of Clinical Evidence |
| title_fullStr | Cerebral Diseases in Liver Transplant Recipients: Systematic Review of Clinical Evidence |
| title_full_unstemmed | Cerebral Diseases in Liver Transplant Recipients: Systematic Review of Clinical Evidence |
| title_short | Cerebral Diseases in Liver Transplant Recipients: Systematic Review of Clinical Evidence |
| title_sort | cerebral diseases in liver transplant recipients systematic review of clinical evidence |
| topic | liver transplantation early postoperative complications long-term follow-up complications postoperative neurological complications intracranial hemorrhage postoperative cerebral infection after liver transplant |
| url | https://www.mdpi.com/2077-0383/11/4/979 |
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