Neurophysiological Biomarkers of Persistent Post-concussive Symptoms: A Scoping Review
Background and Objectives: Persistent post-concussive symptoms (PCS) consist of neurologic and psychological complaints persisting after a mild traumatic brain injury (mTBI). It affects up to 50% of mTBI patients, may cause long-term disability, and reduce patients' quality of life. The aim of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.687197/full |
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| author | Sepehr Mortaheb Sepehr Mortaheb Sepehr Mortaheb Maria Maddalena Filippini Maria Maddalena Filippini Maria Maddalena Filippini Jean-François Kaux Jitka Annen Jitka Annen Nicolas Lejeune Nicolas Lejeune Nicolas Lejeune Géraldine Martens Géraldine Martens Maria Antonia Fuentes Calderón Steven Laureys Steven Laureys Aurore Thibaut Aurore Thibaut |
| author_facet | Sepehr Mortaheb Sepehr Mortaheb Sepehr Mortaheb Maria Maddalena Filippini Maria Maddalena Filippini Maria Maddalena Filippini Jean-François Kaux Jitka Annen Jitka Annen Nicolas Lejeune Nicolas Lejeune Nicolas Lejeune Géraldine Martens Géraldine Martens Maria Antonia Fuentes Calderón Steven Laureys Steven Laureys Aurore Thibaut Aurore Thibaut |
| author_sort | Sepehr Mortaheb |
| collection | DOAJ |
| description | Background and Objectives: Persistent post-concussive symptoms (PCS) consist of neurologic and psychological complaints persisting after a mild traumatic brain injury (mTBI). It affects up to 50% of mTBI patients, may cause long-term disability, and reduce patients' quality of life. The aim of this review was to examine the possible use of different neuroimaging modalities in PCS.Methods: Articles from Pubmed database were screened to extract studies that investigated the relationship between any neuroimaging features and symptoms of PCS. Descriptive statistics were applied to report the results.Results: A total of 80 out of 939 papers were included in the final review. Ten examined conventional MRI (30% positive finding), 24 examined diffusion weighted imaging (54.17% positive finding), 23 examined functional MRI (82.61% positive finding), nine examined electro(magneto)encephalography (77.78% positive finding), and 14 examined other techniques (71% positive finding).Conclusion: MRI was the most widely used technique, while functional techniques seem to be the most sensitive tools to evaluate PCS. The common functional patterns associated with symptoms of PCS were a decreased anti-correlation between the default mode network and the task positive network and reduced brain activity in specific areas (most often in the prefrontal cortex).Significance: Our findings highlight the importance to use functional approaches which demonstrated a functional alteration in brain connectivity and activity in most studies assessing PCS. |
| first_indexed | 2024-12-16T14:36:52Z |
| format | Article |
| id | doaj.art-0fc2059b859341dcab3e785e7803bd54 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-16T14:36:52Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-0fc2059b859341dcab3e785e7803bd542022-12-21T22:28:04ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-09-011210.3389/fneur.2021.687197687197Neurophysiological Biomarkers of Persistent Post-concussive Symptoms: A Scoping ReviewSepehr Mortaheb0Sepehr Mortaheb1Sepehr Mortaheb2Maria Maddalena Filippini3Maria Maddalena Filippini4Maria Maddalena Filippini5Jean-François Kaux6Jitka Annen7Jitka Annen8Nicolas Lejeune9Nicolas Lejeune10Nicolas Lejeune11Géraldine Martens12Géraldine Martens13Maria Antonia Fuentes Calderón14Steven Laureys15Steven Laureys16Aurore Thibaut17Aurore Thibaut18Coma Science Group, GIGA-Consciousness, University of Liège, Liège, BelgiumBrain Clinic, University Hospital of Liège, Liège, BelgiumPhysiology of Cognition Lab., GIGA-Consciousness, University of Liège, Liège, BelgiumComa Science Group, GIGA-Consciousness, University of Liège, Liège, BelgiumBrain Clinic, University Hospital of Liège, Liège, BelgiumNeuromotor and Rehabilitation Department, Azienda Unita Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico (USL-IRCSS) di Reggio Emilia, Reggio Emilia, ItalyPhysical Medicine and Sport Traumatology Department, Sports, FIFA Medical Centre of Excellence, IOC Research Centre for Prevention of Injury and Protection of Athletes Health, FIMS Collaborative Centre of Sport Medicine, University and University Hospital of Liège, Liège, BelgiumComa Science Group, GIGA-Consciousness, University of Liège, Liège, BelgiumBrain Clinic, University Hospital of Liège, Liège, BelgiumComa Science Group, GIGA-Consciousness, University of Liège, Liège, BelgiumBrain Clinic, University Hospital of Liège, Liège, BelgiumInstitute of NeuroScience, University of Louvain, Brussels, BelgiumComa Science Group, GIGA-Consciousness, University of Liège, Liège, BelgiumPhysical Medicine and Sport Traumatology Department, Sports, FIFA Medical Centre of Excellence, IOC Research Centre for Prevention of Injury and Protection of Athletes Health, FIMS Collaborative Centre of Sport Medicine, University and University Hospital of Liège, Liège, BelgiumNeurorehabilitation (NEURORHB) Servicio de Neurorrehabilitación de Hospitales Vithas, Valencia, SpainComa Science Group, GIGA-Consciousness, University of Liège, Liège, BelgiumBrain Clinic, University Hospital of Liège, Liège, BelgiumComa Science Group, GIGA-Consciousness, University of Liège, Liège, BelgiumBrain Clinic, University Hospital of Liège, Liège, BelgiumBackground and Objectives: Persistent post-concussive symptoms (PCS) consist of neurologic and psychological complaints persisting after a mild traumatic brain injury (mTBI). It affects up to 50% of mTBI patients, may cause long-term disability, and reduce patients' quality of life. The aim of this review was to examine the possible use of different neuroimaging modalities in PCS.Methods: Articles from Pubmed database were screened to extract studies that investigated the relationship between any neuroimaging features and symptoms of PCS. Descriptive statistics were applied to report the results.Results: A total of 80 out of 939 papers were included in the final review. Ten examined conventional MRI (30% positive finding), 24 examined diffusion weighted imaging (54.17% positive finding), 23 examined functional MRI (82.61% positive finding), nine examined electro(magneto)encephalography (77.78% positive finding), and 14 examined other techniques (71% positive finding).Conclusion: MRI was the most widely used technique, while functional techniques seem to be the most sensitive tools to evaluate PCS. The common functional patterns associated with symptoms of PCS were a decreased anti-correlation between the default mode network and the task positive network and reduced brain activity in specific areas (most often in the prefrontal cortex).Significance: Our findings highlight the importance to use functional approaches which demonstrated a functional alteration in brain connectivity and activity in most studies assessing PCS.https://www.frontiersin.org/articles/10.3389/fneur.2021.687197/fullneuroimagingpersistent post-concussive symptomsdiffusion weighted imagingfunctional MRIelectroencephalographymTBI |
| spellingShingle | Sepehr Mortaheb Sepehr Mortaheb Sepehr Mortaheb Maria Maddalena Filippini Maria Maddalena Filippini Maria Maddalena Filippini Jean-François Kaux Jitka Annen Jitka Annen Nicolas Lejeune Nicolas Lejeune Nicolas Lejeune Géraldine Martens Géraldine Martens Maria Antonia Fuentes Calderón Steven Laureys Steven Laureys Aurore Thibaut Aurore Thibaut Neurophysiological Biomarkers of Persistent Post-concussive Symptoms: A Scoping Review Frontiers in Neurology neuroimaging persistent post-concussive symptoms diffusion weighted imaging functional MRI electroencephalography mTBI |
| title | Neurophysiological Biomarkers of Persistent Post-concussive Symptoms: A Scoping Review |
| title_full | Neurophysiological Biomarkers of Persistent Post-concussive Symptoms: A Scoping Review |
| title_fullStr | Neurophysiological Biomarkers of Persistent Post-concussive Symptoms: A Scoping Review |
| title_full_unstemmed | Neurophysiological Biomarkers of Persistent Post-concussive Symptoms: A Scoping Review |
| title_short | Neurophysiological Biomarkers of Persistent Post-concussive Symptoms: A Scoping Review |
| title_sort | neurophysiological biomarkers of persistent post concussive symptoms a scoping review |
| topic | neuroimaging persistent post-concussive symptoms diffusion weighted imaging functional MRI electroencephalography mTBI |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.687197/full |
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