Myeloid-derived suppressor cell: A crucial player in autoimmune diseases
Myeloid-derived suppressor cells (MDSCs) are identified as a highly heterogeneous group of immature cells derived from bone marrow and play critical immunosuppressive functions in autoimmune diseases. Accumulating evidence indicates that the pathophysiology of autoimmune diseases was closely related...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1021612/full |
| _version_ | 1828117908825309184 |
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| author | Dandan Xu Cheng Li Yushan Xu Mingyue Huang Dawei Cui Jue Xie |
| author_facet | Dandan Xu Cheng Li Yushan Xu Mingyue Huang Dawei Cui Jue Xie |
| author_sort | Dandan Xu |
| collection | DOAJ |
| description | Myeloid-derived suppressor cells (MDSCs) are identified as a highly heterogeneous group of immature cells derived from bone marrow and play critical immunosuppressive functions in autoimmune diseases. Accumulating evidence indicates that the pathophysiology of autoimmune diseases was closely related to genetic mutations and epigenetic modifications, with the latter more common. Epigenetic modifications, which involve DNA methylation, covalent histone modification, and non-coding RNA-mediated regulation, refer to inheritable and potentially reversible changes in DNA and chromatin that regulate gene expression without altering the DNA sequence. Recently, numerous reports have shown that epigenetic modifications in MDSCs play important roles in the differentiation and development of MDSCs and their suppressive functions. The molecular mechanisms of differentiation and development of MDSCs and their regulatory roles in the initiation and progression of autoimmune diseases have been extensively studied, but the exact function of MDSCs remains controversial. Therefore, the biological and epigenetic regulation of MDSCs in autoimmune diseases still needs to be further characterized. This review provides a detailed summary of the current research on the regulatory roles of DNA methylation, histone modifications, and non-coding RNAs in the development and immunosuppressive activity of MDSCs, and further summarizes the distinct role of MDSCs in the pathogenesis of autoimmune diseases, in order to provide help for the diagnosis and treatment of diseases from the perspective of epigenetic regulation of MDSCs. |
| first_indexed | 2024-04-11T13:23:08Z |
| format | Article |
| id | doaj.art-0fc28d4183034b39b56f51eda4db9e9e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T13:23:08Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0fc28d4183034b39b56f51eda4db9e9e2022-12-22T04:22:09ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-12-011310.3389/fimmu.2022.10216121021612Myeloid-derived suppressor cell: A crucial player in autoimmune diseasesDandan Xu0Cheng Li1Yushan Xu2Mingyue Huang3Dawei Cui4Jue Xie5Department of Blood Transfusion, The First Affiliated Hospital, School of Medicine, Hangzhou, Zhejiang University, ChinaSchool of Medicine, Southern University of Science and Technology, Shenzhen, ChinaDepartment of Blood Transfusion, The First Affiliated Hospital, School of Medicine, Hangzhou, Zhejiang University, ChinaSchool of Medicine, Southern University of Science and Technology, Shenzhen, ChinaDepartment of Blood Transfusion, The First Affiliated Hospital, School of Medicine, Hangzhou, Zhejiang University, ChinaDepartment of Blood Transfusion, The First Affiliated Hospital, School of Medicine, Hangzhou, Zhejiang University, ChinaMyeloid-derived suppressor cells (MDSCs) are identified as a highly heterogeneous group of immature cells derived from bone marrow and play critical immunosuppressive functions in autoimmune diseases. Accumulating evidence indicates that the pathophysiology of autoimmune diseases was closely related to genetic mutations and epigenetic modifications, with the latter more common. Epigenetic modifications, which involve DNA methylation, covalent histone modification, and non-coding RNA-mediated regulation, refer to inheritable and potentially reversible changes in DNA and chromatin that regulate gene expression without altering the DNA sequence. Recently, numerous reports have shown that epigenetic modifications in MDSCs play important roles in the differentiation and development of MDSCs and their suppressive functions. The molecular mechanisms of differentiation and development of MDSCs and their regulatory roles in the initiation and progression of autoimmune diseases have been extensively studied, but the exact function of MDSCs remains controversial. Therefore, the biological and epigenetic regulation of MDSCs in autoimmune diseases still needs to be further characterized. This review provides a detailed summary of the current research on the regulatory roles of DNA methylation, histone modifications, and non-coding RNAs in the development and immunosuppressive activity of MDSCs, and further summarizes the distinct role of MDSCs in the pathogenesis of autoimmune diseases, in order to provide help for the diagnosis and treatment of diseases from the perspective of epigenetic regulation of MDSCs.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1021612/fullmyeloid-derived suppressor cellsDNA methylationhistone modificationnon-coding RNAs regulationautoimmune diseases |
| spellingShingle | Dandan Xu Cheng Li Yushan Xu Mingyue Huang Dawei Cui Jue Xie Myeloid-derived suppressor cell: A crucial player in autoimmune diseases Frontiers in Immunology myeloid-derived suppressor cells DNA methylation histone modification non-coding RNAs regulation autoimmune diseases |
| title | Myeloid-derived suppressor cell: A crucial player in autoimmune diseases |
| title_full | Myeloid-derived suppressor cell: A crucial player in autoimmune diseases |
| title_fullStr | Myeloid-derived suppressor cell: A crucial player in autoimmune diseases |
| title_full_unstemmed | Myeloid-derived suppressor cell: A crucial player in autoimmune diseases |
| title_short | Myeloid-derived suppressor cell: A crucial player in autoimmune diseases |
| title_sort | myeloid derived suppressor cell a crucial player in autoimmune diseases |
| topic | myeloid-derived suppressor cells DNA methylation histone modification non-coding RNAs regulation autoimmune diseases |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1021612/full |
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