The association between hypothyroidism and proteinuria in patients with chronic kidney disease: a cross-sectional study
Abstract Hypothyroidism is known to be correlated with kidney function and nephrotic range proteinuria. However, it is uncertain whether non-nephrotic proteinuria is associated with hypothyroidism. This study aimed to evaluate the association of proteinuria and hypothyroidism in chronic kidney disea...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-19226-0 |
| _version_ | 1828114363899183104 |
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| author | Natsumi Matsuoka-Uchiyama Kenji Tsuji Yizhen Sang Kensaku Takahashi Kazuhiko Fukushima Hidemi Takeuchi Kenichi Inagaki Haruhito A. Uchida Shinji Kitamura Hitoshi Sugiyama Jun Wada |
| author_facet | Natsumi Matsuoka-Uchiyama Kenji Tsuji Yizhen Sang Kensaku Takahashi Kazuhiko Fukushima Hidemi Takeuchi Kenichi Inagaki Haruhito A. Uchida Shinji Kitamura Hitoshi Sugiyama Jun Wada |
| author_sort | Natsumi Matsuoka-Uchiyama |
| collection | DOAJ |
| description | Abstract Hypothyroidism is known to be correlated with kidney function and nephrotic range proteinuria. However, it is uncertain whether non-nephrotic proteinuria is associated with hypothyroidism. This study aimed to evaluate the association of proteinuria and hypothyroidism in chronic kidney disease (CKD) patients. We conducted a cross-sectional study composed of 421 CKD patients in a single hospital with measurements of 24-h urine protein excretion (UP) and thyroid function tests. Spearman correlation analysis revealed that 24-h Cr clearance (24hrCcr) was positively (r = 0.273, p < 0.001) and UP was negatively (r = − 0.207, p < 0.001) correlated with free triiodothyronine. Frequency distribution analysis stratified by CKD stage and UP for hypothyroidism revealed that the prevalence of hypothyroidism was higher among participants with higher CKD stage and nephrotic range proteinuria. Multivariate logistic regression analysis revealed that 24hrCcr and UP were significantly correlated with hypothyroidism (24hrCcr/10 mL/min decrease: odds ratio [OR], 1.29; 95% confidence interval [CI], 1.18–1.41; UP/1 g increase: OR, 1.10; 95% CI, 1.03–1.17). In addition, nephrotic range proteinuria, but not moderate UP (UP: 1.5–3.49 g/day), was significantly correlated with hypothyroidism compared to UP < 0.5 g/day. In summary, decreased kidney function and nephrotic range proteinuria, not non-nephrotic proteinuria, are independently associated with the hypothyroidism. |
| first_indexed | 2024-04-11T12:23:17Z |
| format | Article |
| id | doaj.art-0fc8e73943844e1db6f315d0ad86c8cf |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T12:23:17Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0fc8e73943844e1db6f315d0ad86c8cf2022-12-22T04:24:01ZengNature PortfolioScientific Reports2045-23222022-09-0112111110.1038/s41598-022-19226-0The association between hypothyroidism and proteinuria in patients with chronic kidney disease: a cross-sectional studyNatsumi Matsuoka-Uchiyama0Kenji Tsuji1Yizhen Sang2Kensaku Takahashi3Kazuhiko Fukushima4Hidemi Takeuchi5Kenichi Inagaki6Haruhito A. Uchida7Shinji Kitamura8Hitoshi Sugiyama9Jun Wada10Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Chronic Kidney Disease and Cardiovascular Disease, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Human Resource Development of Dialysis Therapy for Kidney Disease, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesAbstract Hypothyroidism is known to be correlated with kidney function and nephrotic range proteinuria. However, it is uncertain whether non-nephrotic proteinuria is associated with hypothyroidism. This study aimed to evaluate the association of proteinuria and hypothyroidism in chronic kidney disease (CKD) patients. We conducted a cross-sectional study composed of 421 CKD patients in a single hospital with measurements of 24-h urine protein excretion (UP) and thyroid function tests. Spearman correlation analysis revealed that 24-h Cr clearance (24hrCcr) was positively (r = 0.273, p < 0.001) and UP was negatively (r = − 0.207, p < 0.001) correlated with free triiodothyronine. Frequency distribution analysis stratified by CKD stage and UP for hypothyroidism revealed that the prevalence of hypothyroidism was higher among participants with higher CKD stage and nephrotic range proteinuria. Multivariate logistic regression analysis revealed that 24hrCcr and UP were significantly correlated with hypothyroidism (24hrCcr/10 mL/min decrease: odds ratio [OR], 1.29; 95% confidence interval [CI], 1.18–1.41; UP/1 g increase: OR, 1.10; 95% CI, 1.03–1.17). In addition, nephrotic range proteinuria, but not moderate UP (UP: 1.5–3.49 g/day), was significantly correlated with hypothyroidism compared to UP < 0.5 g/day. In summary, decreased kidney function and nephrotic range proteinuria, not non-nephrotic proteinuria, are independently associated with the hypothyroidism.https://doi.org/10.1038/s41598-022-19226-0 |
| spellingShingle | Natsumi Matsuoka-Uchiyama Kenji Tsuji Yizhen Sang Kensaku Takahashi Kazuhiko Fukushima Hidemi Takeuchi Kenichi Inagaki Haruhito A. Uchida Shinji Kitamura Hitoshi Sugiyama Jun Wada The association between hypothyroidism and proteinuria in patients with chronic kidney disease: a cross-sectional study Scientific Reports |
| title | The association between hypothyroidism and proteinuria in patients with chronic kidney disease: a cross-sectional study |
| title_full | The association between hypothyroidism and proteinuria in patients with chronic kidney disease: a cross-sectional study |
| title_fullStr | The association between hypothyroidism and proteinuria in patients with chronic kidney disease: a cross-sectional study |
| title_full_unstemmed | The association between hypothyroidism and proteinuria in patients with chronic kidney disease: a cross-sectional study |
| title_short | The association between hypothyroidism and proteinuria in patients with chronic kidney disease: a cross-sectional study |
| title_sort | association between hypothyroidism and proteinuria in patients with chronic kidney disease a cross sectional study |
| url | https://doi.org/10.1038/s41598-022-19226-0 |
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