ArhGAP11A mediates amyloid-β generation and neuropathology in an Alzheimer’s disease-like mouse model

ArhGAP11A mediates amyloid-β generation and neuropathology in an Alzheimer’s disease-like mouse model

Summary: Amyloid-β (Aβ) plays an important role in the neuropathology of Alzheimer’s disease (AD), but some factors promoting Aβ generation and Aβ oligomer (Aβo) neurotoxicity remain unclear. We here find that the levels of ArhGAP11A, a Ras homology GTPase-activating protein, significantly increase...

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Bibliographic Details
Main Authors: Ya-ru Huang, Xi-xiu Xie, Jing Yang, Xiao-ying Sun, Xiao-yun Niu, Cheng-gang Yang, Ling-jie Li, Lun Zhang, Dan Wang, Chun-yu Liu, Sheng-jie Hou, Chen-yang Jiang, Yu-ming Xu, Rui-tian Liu
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723006356

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