Prognostic value of early radiological response to first‐line platinum‐containing chemotherapy in patients with metastatic nasopharyngeal carcinoma
Abstract Background To explore the prognostic value of early radiological response (ERR) to first‐line platinum‐containing chemotherapy in patients with metastatic nasopharyngeal carcinoma (mNPC), as well as its correlation with the best radiological response (BRR). Patients and methods A total of 7...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-02-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.2751 |
| _version_ | 1797984802065874944 |
|---|---|
| author | Guo‐Ying Liu Wang‐Zhong Li Kang‐Qiang Peng Xing Lv Liang‐Ru Ke Yi‐Shan Wu De‐Ling Wang Hu Liang Kui‐Yuan Liu Shu‐Hui Lv Xiang Guo Yan‐Qun Xiang Wei‐Xiong Xia |
| author_facet | Guo‐Ying Liu Wang‐Zhong Li Kang‐Qiang Peng Xing Lv Liang‐Ru Ke Yi‐Shan Wu De‐Ling Wang Hu Liang Kui‐Yuan Liu Shu‐Hui Lv Xiang Guo Yan‐Qun Xiang Wei‐Xiong Xia |
| author_sort | Guo‐Ying Liu |
| collection | DOAJ |
| description | Abstract Background To explore the prognostic value of early radiological response (ERR) to first‐line platinum‐containing chemotherapy in patients with metastatic nasopharyngeal carcinoma (mNPC), as well as its correlation with the best radiological response (BRR). Patients and methods A total of 756 mNPC patients with measurable lesions who received first‐line platinum‐containing chemotherapy were enrolled in this study. ERR was defined as complete or partial response after 6 weeks of chemotherapy according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. We performed survival analyses according to the radiological response after repeated chemotherapy. Log‐rank test and Cox regression were used to analyze the survival data. Results About 470 patients achieved ERR and 78 patients achieved subsequent response (objective response after repeated chemotherapy). ERR patients had better OS (P < .001, median OS: 34.3 vs 22.2 months) and PFS (P < .001, median PFS: 10.2 vs 7.4 months) than non‐ERR ones. ERR (OS: HR = 0.591, 95% CI, 0.495‐0.705, P < .001, PFS: HR = 0.586, 95% CI, 0.500‐0.686, P < .001) was independently prolonged survival compared with non‐ERR ones. Besides, ERR was significantly correlated with the BRR (Kappa: 0.73; Pearson: 0.74, P < .001), and had significantly longer OS and PFS than patients with subsequent response, respectively. Conclusion ERR is an independent prognostic factor in determining survival in mNPC patients received first‐line platinum‐containing chemotherapy, which may be a more sensitive predictor to assess overall efficacy of systemic treatment than BRR in mNPC. Prospective validation studies are needed. |
| first_indexed | 2024-04-11T07:08:35Z |
| format | Article |
| id | doaj.art-0fc9b1ce5110430abfbceff814ed02cf |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-11T07:08:35Z |
| publishDate | 2020-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-0fc9b1ce5110430abfbceff814ed02cf2022-12-22T04:38:17ZengWileyCancer Medicine2045-76342020-02-019392093010.1002/cam4.2751Prognostic value of early radiological response to first‐line platinum‐containing chemotherapy in patients with metastatic nasopharyngeal carcinomaGuo‐Ying Liu0Wang‐Zhong Li1Kang‐Qiang Peng2Xing Lv3Liang‐Ru Ke4Yi‐Shan Wu5De‐Ling Wang6Hu Liang7Kui‐Yuan Liu8Shu‐Hui Lv9Xiang Guo10Yan‐Qun Xiang11Wei‐Xiong Xia12State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat‐Sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat‐Sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat‐Sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat‐Sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat‐Sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat‐Sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat‐Sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat‐Sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat‐Sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat‐Sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat‐Sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat‐Sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat‐Sen University Cancer Center Guangzhou ChinaAbstract Background To explore the prognostic value of early radiological response (ERR) to first‐line platinum‐containing chemotherapy in patients with metastatic nasopharyngeal carcinoma (mNPC), as well as its correlation with the best radiological response (BRR). Patients and methods A total of 756 mNPC patients with measurable lesions who received first‐line platinum‐containing chemotherapy were enrolled in this study. ERR was defined as complete or partial response after 6 weeks of chemotherapy according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. We performed survival analyses according to the radiological response after repeated chemotherapy. Log‐rank test and Cox regression were used to analyze the survival data. Results About 470 patients achieved ERR and 78 patients achieved subsequent response (objective response after repeated chemotherapy). ERR patients had better OS (P < .001, median OS: 34.3 vs 22.2 months) and PFS (P < .001, median PFS: 10.2 vs 7.4 months) than non‐ERR ones. ERR (OS: HR = 0.591, 95% CI, 0.495‐0.705, P < .001, PFS: HR = 0.586, 95% CI, 0.500‐0.686, P < .001) was independently prolonged survival compared with non‐ERR ones. Besides, ERR was significantly correlated with the BRR (Kappa: 0.73; Pearson: 0.74, P < .001), and had significantly longer OS and PFS than patients with subsequent response, respectively. Conclusion ERR is an independent prognostic factor in determining survival in mNPC patients received first‐line platinum‐containing chemotherapy, which may be a more sensitive predictor to assess overall efficacy of systemic treatment than BRR in mNPC. Prospective validation studies are needed.https://doi.org/10.1002/cam4.2751early radiological responsefirst‐line chemotherapymetastatic nasopharyngeal carcinoma |
| spellingShingle | Guo‐Ying Liu Wang‐Zhong Li Kang‐Qiang Peng Xing Lv Liang‐Ru Ke Yi‐Shan Wu De‐Ling Wang Hu Liang Kui‐Yuan Liu Shu‐Hui Lv Xiang Guo Yan‐Qun Xiang Wei‐Xiong Xia Prognostic value of early radiological response to first‐line platinum‐containing chemotherapy in patients with metastatic nasopharyngeal carcinoma Cancer Medicine early radiological response first‐line chemotherapy metastatic nasopharyngeal carcinoma |
| title | Prognostic value of early radiological response to first‐line platinum‐containing chemotherapy in patients with metastatic nasopharyngeal carcinoma |
| title_full | Prognostic value of early radiological response to first‐line platinum‐containing chemotherapy in patients with metastatic nasopharyngeal carcinoma |
| title_fullStr | Prognostic value of early radiological response to first‐line platinum‐containing chemotherapy in patients with metastatic nasopharyngeal carcinoma |
| title_full_unstemmed | Prognostic value of early radiological response to first‐line platinum‐containing chemotherapy in patients with metastatic nasopharyngeal carcinoma |
| title_short | Prognostic value of early radiological response to first‐line platinum‐containing chemotherapy in patients with metastatic nasopharyngeal carcinoma |
| title_sort | prognostic value of early radiological response to first line platinum containing chemotherapy in patients with metastatic nasopharyngeal carcinoma |
| topic | early radiological response first‐line chemotherapy metastatic nasopharyngeal carcinoma |
| url | https://doi.org/10.1002/cam4.2751 |
| work_keys_str_mv | AT guoyingliu prognosticvalueofearlyradiologicalresponsetofirstlineplatinumcontainingchemotherapyinpatientswithmetastaticnasopharyngealcarcinoma AT wangzhongli prognosticvalueofearlyradiologicalresponsetofirstlineplatinumcontainingchemotherapyinpatientswithmetastaticnasopharyngealcarcinoma AT kangqiangpeng prognosticvalueofearlyradiologicalresponsetofirstlineplatinumcontainingchemotherapyinpatientswithmetastaticnasopharyngealcarcinoma AT xinglv prognosticvalueofearlyradiologicalresponsetofirstlineplatinumcontainingchemotherapyinpatientswithmetastaticnasopharyngealcarcinoma AT liangruke prognosticvalueofearlyradiologicalresponsetofirstlineplatinumcontainingchemotherapyinpatientswithmetastaticnasopharyngealcarcinoma AT yishanwu prognosticvalueofearlyradiologicalresponsetofirstlineplatinumcontainingchemotherapyinpatientswithmetastaticnasopharyngealcarcinoma AT delingwang prognosticvalueofearlyradiologicalresponsetofirstlineplatinumcontainingchemotherapyinpatientswithmetastaticnasopharyngealcarcinoma AT huliang prognosticvalueofearlyradiologicalresponsetofirstlineplatinumcontainingchemotherapyinpatientswithmetastaticnasopharyngealcarcinoma AT kuiyuanliu prognosticvalueofearlyradiologicalresponsetofirstlineplatinumcontainingchemotherapyinpatientswithmetastaticnasopharyngealcarcinoma AT shuhuilv prognosticvalueofearlyradiologicalresponsetofirstlineplatinumcontainingchemotherapyinpatientswithmetastaticnasopharyngealcarcinoma AT xiangguo prognosticvalueofearlyradiologicalresponsetofirstlineplatinumcontainingchemotherapyinpatientswithmetastaticnasopharyngealcarcinoma AT yanqunxiang prognosticvalueofearlyradiologicalresponsetofirstlineplatinumcontainingchemotherapyinpatientswithmetastaticnasopharyngealcarcinoma AT weixiongxia prognosticvalueofearlyradiologicalresponsetofirstlineplatinumcontainingchemotherapyinpatientswithmetastaticnasopharyngealcarcinoma |