LEDGF/p75 Is Required for an Efficient DNA Damage Response

LEDGF/p75 Is Required for an Efficient DNA Damage Response

Lens epithelium-derived growth factor splice variant of 75 kDa (LEDGF/p75) plays an important role in cancer, but its DNA-damage repair (DDR)-related implications are still not completely understood. Different LEDGF model cell lines were generated: a complete knock-out of LEDGF (KO) and re-expressio...

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Bibliographic Details
Main Authors: Victoria Liedtke, Christian Schröder, Dirk Roggenbuck, Romano Weiss, Ralf Stohwasser, Peter Schierack, Stefan Rödiger, Lysann Schenk
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
LEDGF
CRISPR/Cas9
DNA damage signaling
γH2AX
ubiquitination
Online Access:https://www.mdpi.com/1422-0067/22/11/5866

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