Leptin, Both Bad and Good Actor in Cancer
Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in obesity. Leptin exerts many different actions on various tissues and systems, including cancer, and is considered as a linkage between metabolism and the immune system. During the last decades, obesity and l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/6/913 |
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| author | Carlos Jiménez-Cortegana Ana López-Saavedra Flora Sánchez-Jiménez Antonio Pérez-Pérez Jesús Castiñeiras Juan A. Virizuela-Echaburu Luis de la de la Cruz-Merino Víctor Sánchez-Margalet |
| author_facet | Carlos Jiménez-Cortegana Ana López-Saavedra Flora Sánchez-Jiménez Antonio Pérez-Pérez Jesús Castiñeiras Juan A. Virizuela-Echaburu Luis de la de la Cruz-Merino Víctor Sánchez-Margalet |
| author_sort | Carlos Jiménez-Cortegana |
| collection | DOAJ |
| description | Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in obesity. Leptin exerts many different actions on various tissues and systems, including cancer, and is considered as a linkage between metabolism and the immune system. During the last decades, obesity and leptin have been associated with the initiation, proliferation and progression of many types of cancer. Obesity is also linked with complications and mortality, irrespective of the therapy used, affecting clinical outcomes. However, some evidence has suggested its beneficial role, called the “obesity paradox”, and the possible antitumoral role of leptin. Recent data regarding the immunotherapy of cancer have revealed that overweight leads to a more effective response and leptin may probably be involved in this beneficial process. Since leptin is a positive modulator of both the innate and the adaptive immune system, it may contribute to the increased immune response stimulated by immunotherapy in cancer patients and may be proposed as a good actor in cancer. Our purpose is to review this dual role of leptin in cancer, as well as trying to clarify the future perspectives of this adipokine, which further highlights its importance as a cornerstone of the immunometabolism in oncology. |
| first_indexed | 2024-03-10T10:14:19Z |
| format | Article |
| id | doaj.art-0fcbd0f39cc5438ab95f61dcf5678ae2 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T10:14:19Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-0fcbd0f39cc5438ab95f61dcf5678ae22023-11-22T00:54:44ZengMDPI AGBiomolecules2218-273X2021-06-0111691310.3390/biom11060913Leptin, Both Bad and Good Actor in CancerCarlos Jiménez-Cortegana0Ana López-Saavedra1Flora Sánchez-Jiménez2Antonio Pérez-Pérez3Jesús Castiñeiras4Juan A. Virizuela-Echaburu5Luis de la de la Cruz-Merino6Víctor Sánchez-Margalet7Department of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, Virgen Macarena University Hospital, University of Seville, 41009 Seville, SpainDepartment of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, Virgen Macarena University Hospital, University of Seville, 41009 Seville, SpainDepartment of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, Virgen Macarena University Hospital, University of Seville, 41009 Seville, SpainDepartment of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, Virgen Macarena University Hospital, University of Seville, 41009 Seville, SpainUrology Service, Virgen Macarena University Hospital, University of Seville, 41009 Sevilla, SpainMedical Oncology Service, Virgen Macarena University Hospital, University of Seville, 41009 Sevilla, SpainMedical Oncology Service, Virgen Macarena University Hospital, University of Seville, 41009 Sevilla, SpainDepartment of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, Virgen Macarena University Hospital, University of Seville, 41009 Seville, SpainLeptin is an important regulator of basal metabolism and food intake, with a pivotal role in obesity. Leptin exerts many different actions on various tissues and systems, including cancer, and is considered as a linkage between metabolism and the immune system. During the last decades, obesity and leptin have been associated with the initiation, proliferation and progression of many types of cancer. Obesity is also linked with complications and mortality, irrespective of the therapy used, affecting clinical outcomes. However, some evidence has suggested its beneficial role, called the “obesity paradox”, and the possible antitumoral role of leptin. Recent data regarding the immunotherapy of cancer have revealed that overweight leads to a more effective response and leptin may probably be involved in this beneficial process. Since leptin is a positive modulator of both the innate and the adaptive immune system, it may contribute to the increased immune response stimulated by immunotherapy in cancer patients and may be proposed as a good actor in cancer. Our purpose is to review this dual role of leptin in cancer, as well as trying to clarify the future perspectives of this adipokine, which further highlights its importance as a cornerstone of the immunometabolism in oncology.https://www.mdpi.com/2218-273X/11/6/913leptinobesityinflammationcancerimmune systemimmunotherapy |
| spellingShingle | Carlos Jiménez-Cortegana Ana López-Saavedra Flora Sánchez-Jiménez Antonio Pérez-Pérez Jesús Castiñeiras Juan A. Virizuela-Echaburu Luis de la de la Cruz-Merino Víctor Sánchez-Margalet Leptin, Both Bad and Good Actor in Cancer Biomolecules leptin obesity inflammation cancer immune system immunotherapy |
| title | Leptin, Both Bad and Good Actor in Cancer |
| title_full | Leptin, Both Bad and Good Actor in Cancer |
| title_fullStr | Leptin, Both Bad and Good Actor in Cancer |
| title_full_unstemmed | Leptin, Both Bad and Good Actor in Cancer |
| title_short | Leptin, Both Bad and Good Actor in Cancer |
| title_sort | leptin both bad and good actor in cancer |
| topic | leptin obesity inflammation cancer immune system immunotherapy |
| url | https://www.mdpi.com/2218-273X/11/6/913 |
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