Comparison of the Effects of Bromelain and Mefenamic Acid on Menstrual Bleeding in Students with Primary Dysmenorrhea: A Double-Blind Randomized Clinical Trial
Introduction: The rate of bleeding is associated with impaired synthesis of endometrial prostaglandins, especially PGE2. One of the most common causes of anemia in women is menstrual bleeding. Bromelain, an enzyme found in pineapple, has anti-inflammatory effects and reduces prostaglandin E2 in infl...
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| Format: | Article |
| Language: | fas |
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Mashhad University of Medical Sciences
2019-01-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| Subjects: | |
| Online Access: | https://ijogi.mums.ac.ir/article_12328_17523638a1d948970ae37d2c7e934aaa.pdf |
| _version_ | 1811328946496602112 |
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| author | Bibi Maryam Mirlashari Zahra Abedian Hasan Rakhshandeh Habibollah Esmaily |
| author_facet | Bibi Maryam Mirlashari Zahra Abedian Hasan Rakhshandeh Habibollah Esmaily |
| author_sort | Bibi Maryam Mirlashari |
| collection | DOAJ |
| description | Introduction: The rate of bleeding is associated with impaired synthesis of endometrial prostaglandins, especially PGE2. One of the most common causes of anemia in women is menstrual bleeding. Bromelain, an enzyme found in pineapple, has anti-inflammatory effects and reduces prostaglandin E2 in inflammatory regions. This study was performed with aim to compare the effects of Bromelain and Mefenamic acid on the amount of menstrual bleeding.
Methods: A double-blind randomized clinical trial was conducted on 90 students with primary dysmenorrhea in dormitories of Velayat University of Iranshahr in 2017. The students were monitored for two cycles with Higham chart in terms of the rate of bleeding. Then, they were randomly assigned to two groups: Bromelain (n=32) and Mefenamic acid (n=34). The Higham chart was completed to measure menstrual bleeding in two cycles of control and two cycles of intervention. The subjects received 250mg capsules of Bromelain or 250mg capsules of Mefenamic acid, if needed, they received two interventional cycles every 6 hours during the first three days. Data was analyzed by SPSS software (version 22) and Mann-Whitney, Paired t-test and independent t-test. P <0.05 was considered significant.
Results: The results of Paired t-test showed significant difference in the amount of bleeding after intervention in the Bromelain group (P = 0.036), but this difference was not significant in the Mefenamic acid group (P = 0.088). The difference between the mean of bleeding in two cycles of intervention compared to the two cycles of control was -6.79 ± 17.57 in the bromelain group and was -5.36 ± 17.57 in the Mefenamic acid group that showed no significant difference (P = 0.744).
Conclusion: Consumption of Bromelain for reducing menstrual bleeding has no difference with Mefenamic acid in primary dysmenorrhea. |
| first_indexed | 2024-04-13T15:35:03Z |
| format | Article |
| id | doaj.art-0fcc0f9c991d44bb8165d6d4b37b030c |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-13T15:35:03Z |
| publishDate | 2019-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-0fcc0f9c991d44bb8165d6d4b37b030c2022-12-22T02:41:18ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632019-01-012111617010.22038/ijogi.2019.1232812328Comparison of the Effects of Bromelain and Mefenamic Acid on Menstrual Bleeding in Students with Primary Dysmenorrhea: A Double-Blind Randomized Clinical TrialBibi Maryam Mirlashari0Zahra Abedian1Hasan Rakhshandeh2Habibollah Esmaily3M.Sc. Student of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.Instructor, Department of Midwifery, Evidence-Based Care Research Center, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.Assistant Professor, Department of Pharmacology, Medicinal Plants Pharmacological Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranProfessor, Department of Epidemiology and Biostatistics, Social Factors Affecting Health Research Center, School of Public Health, Mashhad University of Medical Sciences, Mashhad, Iran.Introduction: The rate of bleeding is associated with impaired synthesis of endometrial prostaglandins, especially PGE2. One of the most common causes of anemia in women is menstrual bleeding. Bromelain, an enzyme found in pineapple, has anti-inflammatory effects and reduces prostaglandin E2 in inflammatory regions. This study was performed with aim to compare the effects of Bromelain and Mefenamic acid on the amount of menstrual bleeding. Methods: A double-blind randomized clinical trial was conducted on 90 students with primary dysmenorrhea in dormitories of Velayat University of Iranshahr in 2017. The students were monitored for two cycles with Higham chart in terms of the rate of bleeding. Then, they were randomly assigned to two groups: Bromelain (n=32) and Mefenamic acid (n=34). The Higham chart was completed to measure menstrual bleeding in two cycles of control and two cycles of intervention. The subjects received 250mg capsules of Bromelain or 250mg capsules of Mefenamic acid, if needed, they received two interventional cycles every 6 hours during the first three days. Data was analyzed by SPSS software (version 22) and Mann-Whitney, Paired t-test and independent t-test. P <0.05 was considered significant. Results: The results of Paired t-test showed significant difference in the amount of bleeding after intervention in the Bromelain group (P = 0.036), but this difference was not significant in the Mefenamic acid group (P = 0.088). The difference between the mean of bleeding in two cycles of intervention compared to the two cycles of control was -6.79 ± 17.57 in the bromelain group and was -5.36 ± 17.57 in the Mefenamic acid group that showed no significant difference (P = 0.744). Conclusion: Consumption of Bromelain for reducing menstrual bleeding has no difference with Mefenamic acid in primary dysmenorrhea.https://ijogi.mums.ac.ir/article_12328_17523638a1d948970ae37d2c7e934aaa.pdfbromelainmefenamic acidmenstrual bleedingprimary dysmenorrhea |
| spellingShingle | Bibi Maryam Mirlashari Zahra Abedian Hasan Rakhshandeh Habibollah Esmaily Comparison of the Effects of Bromelain and Mefenamic Acid on Menstrual Bleeding in Students with Primary Dysmenorrhea: A Double-Blind Randomized Clinical Trial Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān bromelain mefenamic acid menstrual bleeding primary dysmenorrhea |
| title | Comparison of the Effects of Bromelain and Mefenamic Acid on Menstrual Bleeding in Students with Primary Dysmenorrhea: A Double-Blind Randomized Clinical Trial |
| title_full | Comparison of the Effects of Bromelain and Mefenamic Acid on Menstrual Bleeding in Students with Primary Dysmenorrhea: A Double-Blind Randomized Clinical Trial |
| title_fullStr | Comparison of the Effects of Bromelain and Mefenamic Acid on Menstrual Bleeding in Students with Primary Dysmenorrhea: A Double-Blind Randomized Clinical Trial |
| title_full_unstemmed | Comparison of the Effects of Bromelain and Mefenamic Acid on Menstrual Bleeding in Students with Primary Dysmenorrhea: A Double-Blind Randomized Clinical Trial |
| title_short | Comparison of the Effects of Bromelain and Mefenamic Acid on Menstrual Bleeding in Students with Primary Dysmenorrhea: A Double-Blind Randomized Clinical Trial |
| title_sort | comparison of the effects of bromelain and mefenamic acid on menstrual bleeding in students with primary dysmenorrhea a double blind randomized clinical trial |
| topic | bromelain mefenamic acid menstrual bleeding primary dysmenorrhea |
| url | https://ijogi.mums.ac.ir/article_12328_17523638a1d948970ae37d2c7e934aaa.pdf |
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