Ultrasonic tissue characterization of vulnerable carotid plaque: correlation between videodensitometric method and histological examination
<p>Abstract</p> <p>Background</p> <p>To establish the correlation between quantitative analysis based on B-mode ultrasound images of vulnerable carotid plaque and histological examination of the surgically removed plaque, on the basis of a videodensitometric digital tex...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2006-08-01
|
| Series: | Cardiovascular Ultrasound |
| Online Access: | http://www.cardiovascularultrasound.com/content/4/1/32 |
| _version_ | 1819033182784192512 |
|---|---|
| author | Cherri Jesualdo Ramos Simone G Martins Antonio R Murta Junior Luiz O Pazin Filho Antonio Baroncini Liz Andréa V Piccinato Carlos E |
| author_facet | Cherri Jesualdo Ramos Simone G Martins Antonio R Murta Junior Luiz O Pazin Filho Antonio Baroncini Liz Andréa V Piccinato Carlos E |
| author_sort | Cherri Jesualdo |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>To establish the correlation between quantitative analysis based on B-mode ultrasound images of vulnerable carotid plaque and histological examination of the surgically removed plaque, on the basis of a videodensitometric digital texture characterization.</p> <p>Methods</p> <p>Twenty-five patients (18 males, mean age 67 ± 6.9 years) admitted for carotid endarterectomy for extracranial high-grade internal carotid artery stenosis (≥ 70% luminal narrowing) underwent to quantitative ultrasonic tissue characterization of carotid plaque before surgery. A computer software (Carotid Plaque Analysis Software) was developed to perform the videodensitometric analysis. The patients were divided into 2 groups according to symptomatology (group I, 15 symptomatic patients; and group II, 10 patients asymptomatic). Tissue specimens were analysed for lipid, fibromuscular tissue and calcium.</p> <p>Results</p> <p>The first order statistic parameter mean gray level was able to distinguish the groups I and II (<it>p </it>= 0.04). The second order parameter energy also was able to distinguish the groups (<it>p </it>= 0,02). A histological correlation showed a tendency of mean gray level to have progressively greater values from specimens with < 50% to >75% of fibrosis.</p> <p>Conclusion</p> <p>Videodensitometric computer analysis of scan images may be used to identify vulnerable and potentially unstable lipid-rich carotid plaques, which are less echogenic in density than stable or asymptomatic, more densely fibrotic plaques.</p> |
| first_indexed | 2024-12-21T07:13:47Z |
| format | Article |
| id | doaj.art-0fcc75962d7f4b9ea1d36a909b0e7082 |
| institution | Directory Open Access Journal |
| issn | 1476-7120 |
| language | English |
| last_indexed | 2024-12-21T07:13:47Z |
| publishDate | 2006-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Ultrasound |
| spelling | doaj.art-0fcc75962d7f4b9ea1d36a909b0e70822022-12-21T19:11:55ZengBMCCardiovascular Ultrasound1476-71202006-08-01413210.1186/1476-7120-4-32Ultrasonic tissue characterization of vulnerable carotid plaque: correlation between videodensitometric method and histological examinationCherri JesualdoRamos Simone GMartins Antonio RMurta Junior Luiz OPazin Filho AntonioBaroncini Liz Andréa VPiccinato Carlos E<p>Abstract</p> <p>Background</p> <p>To establish the correlation between quantitative analysis based on B-mode ultrasound images of vulnerable carotid plaque and histological examination of the surgically removed plaque, on the basis of a videodensitometric digital texture characterization.</p> <p>Methods</p> <p>Twenty-five patients (18 males, mean age 67 ± 6.9 years) admitted for carotid endarterectomy for extracranial high-grade internal carotid artery stenosis (≥ 70% luminal narrowing) underwent to quantitative ultrasonic tissue characterization of carotid plaque before surgery. A computer software (Carotid Plaque Analysis Software) was developed to perform the videodensitometric analysis. The patients were divided into 2 groups according to symptomatology (group I, 15 symptomatic patients; and group II, 10 patients asymptomatic). Tissue specimens were analysed for lipid, fibromuscular tissue and calcium.</p> <p>Results</p> <p>The first order statistic parameter mean gray level was able to distinguish the groups I and II (<it>p </it>= 0.04). The second order parameter energy also was able to distinguish the groups (<it>p </it>= 0,02). A histological correlation showed a tendency of mean gray level to have progressively greater values from specimens with < 50% to >75% of fibrosis.</p> <p>Conclusion</p> <p>Videodensitometric computer analysis of scan images may be used to identify vulnerable and potentially unstable lipid-rich carotid plaques, which are less echogenic in density than stable or asymptomatic, more densely fibrotic plaques.</p>http://www.cardiovascularultrasound.com/content/4/1/32 |
| spellingShingle | Cherri Jesualdo Ramos Simone G Martins Antonio R Murta Junior Luiz O Pazin Filho Antonio Baroncini Liz Andréa V Piccinato Carlos E Ultrasonic tissue characterization of vulnerable carotid plaque: correlation between videodensitometric method and histological examination Cardiovascular Ultrasound |
| title | Ultrasonic tissue characterization of vulnerable carotid plaque: correlation between videodensitometric method and histological examination |
| title_full | Ultrasonic tissue characterization of vulnerable carotid plaque: correlation between videodensitometric method and histological examination |
| title_fullStr | Ultrasonic tissue characterization of vulnerable carotid plaque: correlation between videodensitometric method and histological examination |
| title_full_unstemmed | Ultrasonic tissue characterization of vulnerable carotid plaque: correlation between videodensitometric method and histological examination |
| title_short | Ultrasonic tissue characterization of vulnerable carotid plaque: correlation between videodensitometric method and histological examination |
| title_sort | ultrasonic tissue characterization of vulnerable carotid plaque correlation between videodensitometric method and histological examination |
| url | http://www.cardiovascularultrasound.com/content/4/1/32 |
| work_keys_str_mv | AT cherrijesualdo ultrasonictissuecharacterizationofvulnerablecarotidplaquecorrelationbetweenvideodensitometricmethodandhistologicalexamination AT ramossimoneg ultrasonictissuecharacterizationofvulnerablecarotidplaquecorrelationbetweenvideodensitometricmethodandhistologicalexamination AT martinsantonior ultrasonictissuecharacterizationofvulnerablecarotidplaquecorrelationbetweenvideodensitometricmethodandhistologicalexamination AT murtajuniorluizo ultrasonictissuecharacterizationofvulnerablecarotidplaquecorrelationbetweenvideodensitometricmethodandhistologicalexamination AT pazinfilhoantonio ultrasonictissuecharacterizationofvulnerablecarotidplaquecorrelationbetweenvideodensitometricmethodandhistologicalexamination AT baroncinilizandreav ultrasonictissuecharacterizationofvulnerablecarotidplaquecorrelationbetweenvideodensitometricmethodandhistologicalexamination AT piccinatocarlose ultrasonictissuecharacterizationofvulnerablecarotidplaquecorrelationbetweenvideodensitometricmethodandhistologicalexamination |