Recovery of <sup>177</sup>Lu from Irradiated HfO<sub>2</sub> Targets for Nuclear Medicine Purposes

A new method of production of one of the most widely used isotopes in nuclear medicine, <sup>177</sup>Lu, with high chemical purity was developed; this method includes irradiation of the HfO<sub>2</sub> target with bremsstrahlung photons. The irradiated target was dissolved i...

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Main Authors: Andrey G. Kazakov, Taisya Y. Ekatova, Julia S. Babenya, Sergey S. Belyshev, Vadim V. Khankin, Alexander A. Kuznetsov, Sergey E. Vinokurov, Boris F. Myasoedov
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
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Online Access:https://www.mdpi.com/1420-3049/27/10/3179
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author Andrey G. Kazakov
Taisya Y. Ekatova
Julia S. Babenya
Sergey S. Belyshev
Vadim V. Khankin
Alexander A. Kuznetsov
Sergey E. Vinokurov
Boris F. Myasoedov
author_facet Andrey G. Kazakov
Taisya Y. Ekatova
Julia S. Babenya
Sergey S. Belyshev
Vadim V. Khankin
Alexander A. Kuznetsov
Sergey E. Vinokurov
Boris F. Myasoedov
author_sort Andrey G. Kazakov
collection DOAJ
description A new method of production of one of the most widely used isotopes in nuclear medicine, <sup>177</sup>Lu, with high chemical purity was developed; this method includes irradiation of the HfO<sub>2</sub> target with bremsstrahlung photons. The irradiated target was dissolved in HF and then diluted and placed onto a column filled with LN resin. Quantitative sorption of <sup>177</sup>Lu could be observed during this process. The column later was rinsed with the mixture of 0.1 M HF and 1 M HNO<sub>3</sub> and then 2 M HNO<sub>3</sub> to remove impurities. Quantitative desorption of <sup>177</sup>Lu was achieved by using 6 M HNO<sub>3</sub>. The developed method of <sup>177</sup>Lu production ensures high purification of this isotope from macroquantities of hafnium and zirconium and radioactive impurities of carrier-free yttrium. The content of <sup>177m</sup>Lu in <sup>177</sup>Lu in photonuclear production was determined. Due to high chemical and radionuclide purity, <sup>177</sup>Lu obtained by the developed method can be used in nuclear medicine.
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spelling doaj.art-0fccc664b7fe4acba002ca5c63f320592023-11-23T12:22:18ZengMDPI AGMolecules1420-30492022-05-012710317910.3390/molecules27103179Recovery of <sup>177</sup>Lu from Irradiated HfO<sub>2</sub> Targets for Nuclear Medicine PurposesAndrey G. Kazakov0Taisya Y. Ekatova1Julia S. Babenya2Sergey S. Belyshev3Vadim V. Khankin4Alexander A. Kuznetsov5Sergey E. Vinokurov6Boris F. Myasoedov7Radiochemistry Laboratory, Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences (GEOKHI RAS), Kosygin St., 19, 119991 Moscow, RussiaRadiochemistry Laboratory, Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences (GEOKHI RAS), Kosygin St., 19, 119991 Moscow, RussiaRadiochemistry Laboratory, Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences (GEOKHI RAS), Kosygin St., 19, 119991 Moscow, RussiaSkobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Leninskie Gory, 1, Bld. 2, 119991 Moscow, RussiaSkobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Leninskie Gory, 1, Bld. 2, 119991 Moscow, RussiaSkobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Leninskie Gory, 1, Bld. 2, 119991 Moscow, RussiaRadiochemistry Laboratory, Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences (GEOKHI RAS), Kosygin St., 19, 119991 Moscow, RussiaRadiochemistry Laboratory, Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences (GEOKHI RAS), Kosygin St., 19, 119991 Moscow, RussiaA new method of production of one of the most widely used isotopes in nuclear medicine, <sup>177</sup>Lu, with high chemical purity was developed; this method includes irradiation of the HfO<sub>2</sub> target with bremsstrahlung photons. The irradiated target was dissolved in HF and then diluted and placed onto a column filled with LN resin. Quantitative sorption of <sup>177</sup>Lu could be observed during this process. The column later was rinsed with the mixture of 0.1 M HF and 1 M HNO<sub>3</sub> and then 2 M HNO<sub>3</sub> to remove impurities. Quantitative desorption of <sup>177</sup>Lu was achieved by using 6 M HNO<sub>3</sub>. The developed method of <sup>177</sup>Lu production ensures high purification of this isotope from macroquantities of hafnium and zirconium and radioactive impurities of carrier-free yttrium. The content of <sup>177m</sup>Lu in <sup>177</sup>Lu in photonuclear production was determined. Due to high chemical and radionuclide purity, <sup>177</sup>Lu obtained by the developed method can be used in nuclear medicine.https://www.mdpi.com/1420-3049/27/10/3179<sup>177</sup>Luextraction chromatographyphotonuclear reactionsradiochemical recoverynuclear medicine
spellingShingle Andrey G. Kazakov
Taisya Y. Ekatova
Julia S. Babenya
Sergey S. Belyshev
Vadim V. Khankin
Alexander A. Kuznetsov
Sergey E. Vinokurov
Boris F. Myasoedov
Recovery of <sup>177</sup>Lu from Irradiated HfO<sub>2</sub> Targets for Nuclear Medicine Purposes
Molecules
<sup>177</sup>Lu
extraction chromatography
photonuclear reactions
radiochemical recovery
nuclear medicine
title Recovery of <sup>177</sup>Lu from Irradiated HfO<sub>2</sub> Targets for Nuclear Medicine Purposes
title_full Recovery of <sup>177</sup>Lu from Irradiated HfO<sub>2</sub> Targets for Nuclear Medicine Purposes
title_fullStr Recovery of <sup>177</sup>Lu from Irradiated HfO<sub>2</sub> Targets for Nuclear Medicine Purposes
title_full_unstemmed Recovery of <sup>177</sup>Lu from Irradiated HfO<sub>2</sub> Targets for Nuclear Medicine Purposes
title_short Recovery of <sup>177</sup>Lu from Irradiated HfO<sub>2</sub> Targets for Nuclear Medicine Purposes
title_sort recovery of sup 177 sup lu from irradiated hfo sub 2 sub targets for nuclear medicine purposes
topic <sup>177</sup>Lu
extraction chromatography
photonuclear reactions
radiochemical recovery
nuclear medicine
url https://www.mdpi.com/1420-3049/27/10/3179
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