Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans.
Compounds that delay aging might also postpone age-related diseases and extend healthspan in humans. Icariin is a flavonol extracted from several plant species of the Epimedium family. The icariin and its metabolic derivatives have been shown to exert wide protective effects in age-related diseases....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3244416?pdf=render |
| _version_ | 1811268880034693120 |
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| author | Wai-Jiao Cai Jian-Hua Huang Su-Qin Zhang Bin Wu Pankaj Kapahi Xin-Min Zhang Zi-Yin Shen |
| author_facet | Wai-Jiao Cai Jian-Hua Huang Su-Qin Zhang Bin Wu Pankaj Kapahi Xin-Min Zhang Zi-Yin Shen |
| author_sort | Wai-Jiao Cai |
| collection | DOAJ |
| description | Compounds that delay aging might also postpone age-related diseases and extend healthspan in humans. Icariin is a flavonol extracted from several plant species of the Epimedium family. The icariin and its metabolic derivatives have been shown to exert wide protective effects in age-related diseases. However, whether icariin and its derivatives have the potency of delaying aging remains unclear. Here, we report that icariin and its derivative icariside II extend C. elegans lifespan. Using HPLC, we found high level of icariside II in the animals treated with icariin, suggesting icariside II is the bioactive form in vivo of icariin. Icariside II also increased the thermo and oxidative stress tolerance, slowed locomotion decline in late adulthood and delayed the onset of paralysis mediated by polyQ and Aβ(1-42) proteotoxicity. The lifespan extension effect of icariside II is dependent on the insulin/IGF-1 signaling (IIS) since the daf-16(mu86) and daf-2(e1370) failed to show any lifespan extension upon icariside II treatment. Consistently, icariside II treatment upregulates the expression of DAF-16 targets in the wild-type. Moreover, our data suggests that the heat shock transcription factor HSF-1 has a role in icariside II-dependent lifespan extension further implicating the IIS pathway. In conclusion, we demonstrate a novel natural compound, icariside II as the bioactive form of icariin, extends the healthspan via IIS pathway in C. elegans. |
| first_indexed | 2024-04-12T21:32:00Z |
| format | Article |
| id | doaj.art-0fccf74b2e6a474ebf9797bf24323b20 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T21:32:00Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0fccf74b2e6a474ebf9797bf24323b202022-12-22T03:16:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-01612e2883510.1371/journal.pone.0028835Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans.Wai-Jiao CaiJian-Hua HuangSu-Qin ZhangBin WuPankaj KapahiXin-Min ZhangZi-Yin ShenCompounds that delay aging might also postpone age-related diseases and extend healthspan in humans. Icariin is a flavonol extracted from several plant species of the Epimedium family. The icariin and its metabolic derivatives have been shown to exert wide protective effects in age-related diseases. However, whether icariin and its derivatives have the potency of delaying aging remains unclear. Here, we report that icariin and its derivative icariside II extend C. elegans lifespan. Using HPLC, we found high level of icariside II in the animals treated with icariin, suggesting icariside II is the bioactive form in vivo of icariin. Icariside II also increased the thermo and oxidative stress tolerance, slowed locomotion decline in late adulthood and delayed the onset of paralysis mediated by polyQ and Aβ(1-42) proteotoxicity. The lifespan extension effect of icariside II is dependent on the insulin/IGF-1 signaling (IIS) since the daf-16(mu86) and daf-2(e1370) failed to show any lifespan extension upon icariside II treatment. Consistently, icariside II treatment upregulates the expression of DAF-16 targets in the wild-type. Moreover, our data suggests that the heat shock transcription factor HSF-1 has a role in icariside II-dependent lifespan extension further implicating the IIS pathway. In conclusion, we demonstrate a novel natural compound, icariside II as the bioactive form of icariin, extends the healthspan via IIS pathway in C. elegans.http://europepmc.org/articles/PMC3244416?pdf=render |
| spellingShingle | Wai-Jiao Cai Jian-Hua Huang Su-Qin Zhang Bin Wu Pankaj Kapahi Xin-Min Zhang Zi-Yin Shen Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS ONE |
| title | Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. |
| title_full | Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. |
| title_fullStr | Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. |
| title_full_unstemmed | Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. |
| title_short | Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. |
| title_sort | icariin and its derivative icariside ii extend healthspan via insulin igf 1 pathway in c elegans |
| url | http://europepmc.org/articles/PMC3244416?pdf=render |
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