High triglyceride-glucose index is associated with subclinical cerebral small vessel disease in a healthy population: a cross-sectional study
Abstract Background The triglyceride-glucose (TyG) index is a marker of insulin resistance (IR) and has been associated with various metabolic syndromes, cardiovascular diseases, and cerebrovascular diseases. However, limited information is available regarding its association with subclinical cerebr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12933-020-01031-6 |
| _version_ | 1818899202524053504 |
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| author | Ki-Woong Nam Hyung-Min Kwon Han-Yeong Jeong Jin-Ho Park Hyuktae Kwon Su-Min Jeong |
| author_facet | Ki-Woong Nam Hyung-Min Kwon Han-Yeong Jeong Jin-Ho Park Hyuktae Kwon Su-Min Jeong |
| author_sort | Ki-Woong Nam |
| collection | DOAJ |
| description | Abstract Background The triglyceride-glucose (TyG) index is a marker of insulin resistance (IR) and has been associated with various metabolic syndromes, cardiovascular diseases, and cerebrovascular diseases. However, limited information is available regarding its association with subclinical cerebral small vessel disease (cSVD). In this study, we evaluated the relationship between the TyG index and cSVD, including silent brain infarcts (SBIs) and white matter hyperintensity (WMH). Methods We assessed health check-up participants aged 40–79 years from 2006 to 2013. The TyG index was calculated using the log scale of fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2. The Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) was also calculated. This was compared with two insulin surrogates and cSVD as another IR indicator and compared the association between two insulin surrogates and cSVD. SBI was measured for both prevalence and burden. The WMH volume was quantitatively rated using a computer-assisted semi-automated technique. Results A total of 2615 participants were evaluated (median age: 56 years, male sex: 53%). In the multivariable logistic regression analysis, the TyG index was seen to be associated with SBI prevalence (adjusted odds ratio: 1.39; 95% confidence interval [CI] = 1.06–1.81). Further quantitative analyses showed a positive dose–response relationship between the TyG index and SBI burden (P for trend = 0.006). In multivariable linear regression analysis, the TyG index was also found to be related to the volume of WMH (β = 0.084; 95% CI = 0.013 to 0.154). Additionally, the TyG index showed a similar or slightly stronger association with the prevalence of SBI and the volume of WMH than did HOMA-IR. Conclusions A high TyG index was associated with a higher prevalence and burden of cSVD in a neurologically healthy population. This marker of IR could be a convenient and useful predictor of cSVD. |
| first_indexed | 2024-12-19T19:44:13Z |
| format | Article |
| id | doaj.art-0fced3102530469681f8f8263363c559 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-19T19:44:13Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-0fced3102530469681f8f8263363c5592022-12-21T20:08:10ZengBMCCardiovascular Diabetology1475-28402020-05-011911810.1186/s12933-020-01031-6High triglyceride-glucose index is associated with subclinical cerebral small vessel disease in a healthy population: a cross-sectional studyKi-Woong Nam0Hyung-Min Kwon1Han-Yeong Jeong2Jin-Ho Park3Hyuktae Kwon4Su-Min Jeong5Department of Neurology, Seoul National University College of Medicine and Seoul National University HospitalDepartment of Neurology, Seoul National University College of Medicine and Seoul Metropolitan Government-Seoul National University Boramae Medical CenterDepartment of Neurology, Seoul National University College of Medicine and Seoul National University HospitalDepartment of Family Medicine, Seoul National University College of Medicine and Seoul National University HospitalDepartment of Family Medicine, Seoul National University College of Medicine and Seoul National University HospitalDepartment of Family Medicine, Seoul National University College of Medicine and Seoul Metropolitan Government-Seoul National University Boramae Medical CenterAbstract Background The triglyceride-glucose (TyG) index is a marker of insulin resistance (IR) and has been associated with various metabolic syndromes, cardiovascular diseases, and cerebrovascular diseases. However, limited information is available regarding its association with subclinical cerebral small vessel disease (cSVD). In this study, we evaluated the relationship between the TyG index and cSVD, including silent brain infarcts (SBIs) and white matter hyperintensity (WMH). Methods We assessed health check-up participants aged 40–79 years from 2006 to 2013. The TyG index was calculated using the log scale of fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2. The Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) was also calculated. This was compared with two insulin surrogates and cSVD as another IR indicator and compared the association between two insulin surrogates and cSVD. SBI was measured for both prevalence and burden. The WMH volume was quantitatively rated using a computer-assisted semi-automated technique. Results A total of 2615 participants were evaluated (median age: 56 years, male sex: 53%). In the multivariable logistic regression analysis, the TyG index was seen to be associated with SBI prevalence (adjusted odds ratio: 1.39; 95% confidence interval [CI] = 1.06–1.81). Further quantitative analyses showed a positive dose–response relationship between the TyG index and SBI burden (P for trend = 0.006). In multivariable linear regression analysis, the TyG index was also found to be related to the volume of WMH (β = 0.084; 95% CI = 0.013 to 0.154). Additionally, the TyG index showed a similar or slightly stronger association with the prevalence of SBI and the volume of WMH than did HOMA-IR. Conclusions A high TyG index was associated with a higher prevalence and burden of cSVD in a neurologically healthy population. This marker of IR could be a convenient and useful predictor of cSVD.http://link.springer.com/article/10.1186/s12933-020-01031-6TriglycerideGlucoseInsulin resistanceLeukoaraiosisLacunes |
| spellingShingle | Ki-Woong Nam Hyung-Min Kwon Han-Yeong Jeong Jin-Ho Park Hyuktae Kwon Su-Min Jeong High triglyceride-glucose index is associated with subclinical cerebral small vessel disease in a healthy population: a cross-sectional study Cardiovascular Diabetology Triglyceride Glucose Insulin resistance Leukoaraiosis Lacunes |
| title | High triglyceride-glucose index is associated with subclinical cerebral small vessel disease in a healthy population: a cross-sectional study |
| title_full | High triglyceride-glucose index is associated with subclinical cerebral small vessel disease in a healthy population: a cross-sectional study |
| title_fullStr | High triglyceride-glucose index is associated with subclinical cerebral small vessel disease in a healthy population: a cross-sectional study |
| title_full_unstemmed | High triglyceride-glucose index is associated with subclinical cerebral small vessel disease in a healthy population: a cross-sectional study |
| title_short | High triglyceride-glucose index is associated with subclinical cerebral small vessel disease in a healthy population: a cross-sectional study |
| title_sort | high triglyceride glucose index is associated with subclinical cerebral small vessel disease in a healthy population a cross sectional study |
| topic | Triglyceride Glucose Insulin resistance Leukoaraiosis Lacunes |
| url | http://link.springer.com/article/10.1186/s12933-020-01031-6 |
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