The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials
Green tea catechins (GTCs) are secondary plant metabolites that have been associated with health benefits in human trials. As such, they have the potential to reduce cardiovascular disease (CVD) risk; however, results are not consistent. This systematic review of the published data assessed the puta...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-06-01
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| Series: | Beverages |
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| Online Access: | http://www.mdpi.com/2306-5710/2/2/16 |
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| author | Sarah O. Lau Ekavi N. Georgousopoulou Jane Kellett Jackson Thomas Andrew McKune Duane Mellor Paul D. Roach Nenad Naumovski |
| author_facet | Sarah O. Lau Ekavi N. Georgousopoulou Jane Kellett Jackson Thomas Andrew McKune Duane Mellor Paul D. Roach Nenad Naumovski |
| author_sort | Sarah O. Lau |
| collection | DOAJ |
| description | Green tea catechins (GTCs) are secondary plant metabolites that have been associated with health benefits in human trials. As such, they have the potential to reduce cardiovascular disease (CVD) risk; however, results are not consistent. This systematic review of the published data assessed the putative effect of GTCs supplementation on anthropometric, blood pressure, and biochemical measures associated with CVD risk. It was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines exploring four major electronic databases (MEDLINE, Cochrane Library, Web of Science, and Scopus). Studies were included if they were published in peer-reviewed journals in English from 1990 until October 2015, and were human double-blind randomized and placebo-controlled trials (RCTs). From 122,428 articles initially identified, after two levels of screening, seven studies met the inclusion criteria. The review revealed consistent and significant (p ≤ 0.05) reductions in body mass index (BMI), blood pressure and plasma lipids; however, this effect would have been less if between-group effects had been considered. The current evidence base also has considerable methodological limitations due to suboptimal statistical methods used in data analyses. Future research efforts must aim to rectify this paucity of evidence with well-designed and well-reported prospective studies. |
| first_indexed | 2024-04-13T16:14:33Z |
| format | Article |
| id | doaj.art-0fd0cc02da8f40669276a27324020d4d |
| institution | Directory Open Access Journal |
| issn | 2306-5710 |
| language | English |
| last_indexed | 2024-04-13T16:14:33Z |
| publishDate | 2016-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Beverages |
| spelling | doaj.art-0fd0cc02da8f40669276a27324020d4d2022-12-22T02:40:06ZengMDPI AGBeverages2306-57102016-06-01221610.3390/beverages2020016beverages2020016The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical TrialsSarah O. Lau0Ekavi N. Georgousopoulou1Jane Kellett2Jackson Thomas3Andrew McKune4Duane Mellor5Paul D. Roach6Nenad Naumovski7Faculty of Health, University of Canberra, Canberra ACT 2601, AustraliaFaculty of Health, University of Canberra, Canberra ACT 2601, AustraliaFaculty of Health, University of Canberra, Canberra ACT 2601, AustraliaFaculty of Health, University of Canberra, Canberra ACT 2601, AustraliaFaculty of Health, University of Canberra, Canberra ACT 2601, AustraliaFaculty of Health, University of Canberra, Canberra ACT 2601, AustraliaFaculty of Health, University of Canberra, Canberra ACT 2601, AustraliaFaculty of Health, University of Canberra, Canberra ACT 2601, AustraliaGreen tea catechins (GTCs) are secondary plant metabolites that have been associated with health benefits in human trials. As such, they have the potential to reduce cardiovascular disease (CVD) risk; however, results are not consistent. This systematic review of the published data assessed the putative effect of GTCs supplementation on anthropometric, blood pressure, and biochemical measures associated with CVD risk. It was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines exploring four major electronic databases (MEDLINE, Cochrane Library, Web of Science, and Scopus). Studies were included if they were published in peer-reviewed journals in English from 1990 until October 2015, and were human double-blind randomized and placebo-controlled trials (RCTs). From 122,428 articles initially identified, after two levels of screening, seven studies met the inclusion criteria. The review revealed consistent and significant (p ≤ 0.05) reductions in body mass index (BMI), blood pressure and plasma lipids; however, this effect would have been less if between-group effects had been considered. The current evidence base also has considerable methodological limitations due to suboptimal statistical methods used in data analyses. Future research efforts must aim to rectify this paucity of evidence with well-designed and well-reported prospective studies.http://www.mdpi.com/2306-5710/2/2/16green tea catechinsGTCsepigallocatechin gallateEGCGsystematic reviewhuman clinical trialscardiovascular disease biomarkers |
| spellingShingle | Sarah O. Lau Ekavi N. Georgousopoulou Jane Kellett Jackson Thomas Andrew McKune Duane Mellor Paul D. Roach Nenad Naumovski The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials Beverages green tea catechins GTCs epigallocatechin gallate EGCG systematic review human clinical trials cardiovascular disease biomarkers |
| title | The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials |
| title_full | The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials |
| title_fullStr | The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials |
| title_full_unstemmed | The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials |
| title_short | The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials |
| title_sort | effect of dietary supplementation of green tea catechins on cardiovascular disease risk markers in humans a systematic review of clinical trials |
| topic | green tea catechins GTCs epigallocatechin gallate EGCG systematic review human clinical trials cardiovascular disease biomarkers |
| url | http://www.mdpi.com/2306-5710/2/2/16 |
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