Janus Kinase Signaling: Oncogenic Criminal of Lymphoid Cancers
The Janus kinase (JAK) family are known to respond to extracellular cytokine stimuli and to phosphorylate and activate signal transducers and activators of transcription (STAT), thereby modulating gene expression profiles. Recent studies have highlighted JAK abnormality in inducing over-activation o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/20/5147 |
| _version_ | 1797515049911189504 |
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| author | Boheng Li Qin Wan Zhubo Li Wee-Joo Chng |
| author_facet | Boheng Li Qin Wan Zhubo Li Wee-Joo Chng |
| author_sort | Boheng Li |
| collection | DOAJ |
| description | The Janus kinase (JAK) family are known to respond to extracellular cytokine stimuli and to phosphorylate and activate signal transducers and activators of transcription (STAT), thereby modulating gene expression profiles. Recent studies have highlighted JAK abnormality in inducing over-activation of the JAK/STAT pathway, and that the cytoplasmic JAK tyrosine kinases may also have a nuclear role. A couple of anti-JAK therapeutics have been developed, which effectively harness lymphoid cancer cells. Here we discuss mutations and fusions leading to JAK deregulations, how upstream nodes drive JAK expression, how classical JAK/STAT pathways are represented in lymphoid malignancies and the noncanonical and nuclear role of JAKs. We also summarize JAK inhibition therapeutics applied alone or synergized with other drugs in treating lymphoid malignancies. |
| first_indexed | 2024-03-10T06:40:08Z |
| format | Article |
| id | doaj.art-0fd0d88991bc42ef907e1671280e8ac9 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T06:40:08Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0fd0d88991bc42ef907e1671280e8ac92023-11-22T17:41:01ZengMDPI AGCancers2072-66942021-10-011320514710.3390/cancers13205147Janus Kinase Signaling: Oncogenic Criminal of Lymphoid CancersBoheng Li0Qin Wan1Zhubo Li2Wee-Joo Chng3College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, ChinaCollege of Pharmaceutical Sciences, Southwest University, Chongqing 400715, ChinaCollege of Pharmaceutical Sciences, Southwest University, Chongqing 400715, ChinaDepartment of Haematology-Oncology, National University Cancer Institute of Singapore, Singapore 119074, SingaporeThe Janus kinase (JAK) family are known to respond to extracellular cytokine stimuli and to phosphorylate and activate signal transducers and activators of transcription (STAT), thereby modulating gene expression profiles. Recent studies have highlighted JAK abnormality in inducing over-activation of the JAK/STAT pathway, and that the cytoplasmic JAK tyrosine kinases may also have a nuclear role. A couple of anti-JAK therapeutics have been developed, which effectively harness lymphoid cancer cells. Here we discuss mutations and fusions leading to JAK deregulations, how upstream nodes drive JAK expression, how classical JAK/STAT pathways are represented in lymphoid malignancies and the noncanonical and nuclear role of JAKs. We also summarize JAK inhibition therapeutics applied alone or synergized with other drugs in treating lymphoid malignancies.https://www.mdpi.com/2072-6694/13/20/5147JAK/STATlymphomamyelomainhibitor |
| spellingShingle | Boheng Li Qin Wan Zhubo Li Wee-Joo Chng Janus Kinase Signaling: Oncogenic Criminal of Lymphoid Cancers Cancers JAK/STAT lymphoma myeloma inhibitor |
| title | Janus Kinase Signaling: Oncogenic Criminal of Lymphoid Cancers |
| title_full | Janus Kinase Signaling: Oncogenic Criminal of Lymphoid Cancers |
| title_fullStr | Janus Kinase Signaling: Oncogenic Criminal of Lymphoid Cancers |
| title_full_unstemmed | Janus Kinase Signaling: Oncogenic Criminal of Lymphoid Cancers |
| title_short | Janus Kinase Signaling: Oncogenic Criminal of Lymphoid Cancers |
| title_sort | janus kinase signaling oncogenic criminal of lymphoid cancers |
| topic | JAK/STAT lymphoma myeloma inhibitor |
| url | https://www.mdpi.com/2072-6694/13/20/5147 |
| work_keys_str_mv | AT bohengli januskinasesignalingoncogeniccriminaloflymphoidcancers AT qinwan januskinasesignalingoncogeniccriminaloflymphoidcancers AT zhuboli januskinasesignalingoncogeniccriminaloflymphoidcancers AT weejoochng januskinasesignalingoncogeniccriminaloflymphoidcancers |