A fiber-modified adenoviral vector interacts with immunoevasion molecules of the B7 family at the surface of murine leukemia cells derived from dormant tumors

A fiber-modified adenoviral vector interacts with immunoevasion molecules of the B7 family at the surface of murine leukemia cells derived from dormant tumors

<p>Abstract</p> <p>Tumor cells can escape the immune system by overexpressing molecules of the B7 family, e.g. B7-H1 (PD-L1 or CD86), which suppresses the anti-tumor T-cell responses through binding to the PD-1 receptor, and similarly for B7.1 (CD80), through binding to CTLA-4. Mor...

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Bibliographic Details
Main Authors: Rogée Sophie, Lécolle Katia, Grellier Elodie, Couturier Cyril, D'Halluin Jean-Claude, Hong Saw-See, Fender Pascal, Boulanger Pierre, Quesnel Bruno, Colin Morvane
Format: Article
Language:English
Published: BMC 2011-08-01
Series:Molecular Cancer
Subjects:
B7-H1
B7.1
dormant leukemia cells
adenovirus
adenovirus vector
atadenovirus
chimeric fiber
Online Access:http://www.molecular-cancer.com/content/10/1/105

Internet

http://www.molecular-cancer.com/content/10/1/105

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