Prediction of incidence of neurological disorders in HIV-infected persons in Taiwan: a nested case–control study
Abstract Background Neurological disorders are still prevalent in HIV-infected people. We aimed to determine the prevalence of neurological disorders and identify their risk factors in HIV-infected persons in Taiwan. Methods We identified 30,101 HIV-infected people between 2002 and 2016 from the Nat...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-023-08761-4 |
| _version_ | 1797637021018095616 |
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| author | Ya-Wei Weng Susan Shin-Jung Lee Hung-Chin Tsai Chih-Hui Hsu Sheng-Hsiang Lin |
| author_facet | Ya-Wei Weng Susan Shin-Jung Lee Hung-Chin Tsai Chih-Hui Hsu Sheng-Hsiang Lin |
| author_sort | Ya-Wei Weng |
| collection | DOAJ |
| description | Abstract Background Neurological disorders are still prevalent in HIV-infected people. We aimed to determine the prevalence of neurological disorders and identify their risk factors in HIV-infected persons in Taiwan. Methods We identified 30,101 HIV-infected people between 2002 and 2016 from the National Health Insurance Research Database in Taiwan, and analyzed the incidence of neurological disorders. We applied a retrospective, nested case–control study design. The individuals with (case group) and without (control group) a neurological disorder were then matched by age, sex and time. Factors associated with neurological disorders were analyzed using a conditional logistic regression model, and a nomogram was generated to estimate the risk of developing a neurological disorder. Results The incidence of neurological disorders was 13.67 per 1000 person-years. The incidence remained stable during the observation period despite the use of early treatment and more tolerable modern anti-retroviral therapy. The conditional logistic regression model identified nine clinical factors and comorbidities that were associated with neurological disorders, namely age, substance use, traumatic brain injury, psychiatric illness, HIV-associated opportunistic infections, frequency of emergency department visits, cART adherence, urbanization, and monthly income. These factors were used to establish the nomogram. Conclusion Neurological disorders are still prevalent in HIV-infected people in Taiwan. To efficiently identify those at risk, we established a nomogram with nine risk factors. This nomogram could prompt clinicians to initiate further evaluations and management of neurological disorders in this population. |
| first_indexed | 2024-03-11T12:43:22Z |
| format | Article |
| id | doaj.art-0fd115a72d5e4a60b72253f5711277da |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-11T12:43:22Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-0fd115a72d5e4a60b72253f5711277da2023-11-05T12:08:59ZengBMCBMC Infectious Diseases1471-23342023-11-0123111010.1186/s12879-023-08761-4Prediction of incidence of neurological disorders in HIV-infected persons in Taiwan: a nested case–control studyYa-Wei Weng0Susan Shin-Jung Lee1Hung-Chin Tsai2Chih-Hui Hsu3Sheng-Hsiang Lin4Institute of Clinical Medicine, College of Medicine, National Cheng Kung UniversityDivision of Infectious Disease, Department of Internal Medicine, Kaohsiung Veterans General HospitalDivision of Infectious Disease, Department of Internal Medicine, Kaohsiung Veterans General HospitalBiostatistics Consulting Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityInstitute of Clinical Medicine, College of Medicine, National Cheng Kung UniversityAbstract Background Neurological disorders are still prevalent in HIV-infected people. We aimed to determine the prevalence of neurological disorders and identify their risk factors in HIV-infected persons in Taiwan. Methods We identified 30,101 HIV-infected people between 2002 and 2016 from the National Health Insurance Research Database in Taiwan, and analyzed the incidence of neurological disorders. We applied a retrospective, nested case–control study design. The individuals with (case group) and without (control group) a neurological disorder were then matched by age, sex and time. Factors associated with neurological disorders were analyzed using a conditional logistic regression model, and a nomogram was generated to estimate the risk of developing a neurological disorder. Results The incidence of neurological disorders was 13.67 per 1000 person-years. The incidence remained stable during the observation period despite the use of early treatment and more tolerable modern anti-retroviral therapy. The conditional logistic regression model identified nine clinical factors and comorbidities that were associated with neurological disorders, namely age, substance use, traumatic brain injury, psychiatric illness, HIV-associated opportunistic infections, frequency of emergency department visits, cART adherence, urbanization, and monthly income. These factors were used to establish the nomogram. Conclusion Neurological disorders are still prevalent in HIV-infected people in Taiwan. To efficiently identify those at risk, we established a nomogram with nine risk factors. This nomogram could prompt clinicians to initiate further evaluations and management of neurological disorders in this population.https://doi.org/10.1186/s12879-023-08761-4HIVNeurological disordersNational health insurance research database |
| spellingShingle | Ya-Wei Weng Susan Shin-Jung Lee Hung-Chin Tsai Chih-Hui Hsu Sheng-Hsiang Lin Prediction of incidence of neurological disorders in HIV-infected persons in Taiwan: a nested case–control study BMC Infectious Diseases HIV Neurological disorders National health insurance research database |
| title | Prediction of incidence of neurological disorders in HIV-infected persons in Taiwan: a nested case–control study |
| title_full | Prediction of incidence of neurological disorders in HIV-infected persons in Taiwan: a nested case–control study |
| title_fullStr | Prediction of incidence of neurological disorders in HIV-infected persons in Taiwan: a nested case–control study |
| title_full_unstemmed | Prediction of incidence of neurological disorders in HIV-infected persons in Taiwan: a nested case–control study |
| title_short | Prediction of incidence of neurological disorders in HIV-infected persons in Taiwan: a nested case–control study |
| title_sort | prediction of incidence of neurological disorders in hiv infected persons in taiwan a nested case control study |
| topic | HIV Neurological disorders National health insurance research database |
| url | https://doi.org/10.1186/s12879-023-08761-4 |
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