Absence of Integrase Inhibitor-Associated Resistance Among Antiretroviral Therapy-Naïve HIV-1-Infected Adults in Guangdong Province, China, in 2018
Yun Lan,1,* Linghua Li,2,* Weilie Chen,1,* Xizi Deng,1 Junbin Li,2 Qinghong Fan,1 Xiaoli Cai,1 Weiping Cai,2 Fengyu Hu1 1Institute of Infectious Disease, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Infectiou...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-12-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/absence-of-integrase-inhibitor-associated-resistance-among-antiretrovi-peer-reviewed-article-IDR |
| _version_ | 1818875605255454720 |
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| author | Lan Y Li L Chen W Deng X Li J Fan Q Cai X Cai W Hu F |
| author_facet | Lan Y Li L Chen W Deng X Li J Fan Q Cai X Cai W Hu F |
| author_sort | Lan Y |
| collection | DOAJ |
| description | Yun Lan,1,* Linghua Li,2,* Weilie Chen,1,* Xizi Deng,1 Junbin Li,2 Qinghong Fan,1 Xiaoli Cai,1 Weiping Cai,2 Fengyu Hu1 1Institute of Infectious Disease, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Infectious Disease Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weiping CaiInfectious Disease Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, 627 Dongfeng East Road, Yuexiu District, Guangzhou 510030, People’s Republic of ChinaTel +86-20-83710825Email gz8hcwp@126.comFengyu HuInstitute of Infectious Disease, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, 627 Dongfeng East Road, Yuexiu District, Guangzhou 510030, People’s Republic of ChinaTel +86-20-83710851Email gz8hhfy@126.comBackground: Antiretroviral therapy (ART) containing an integrase strand transfer inhibitor (INSTI) plus two nucleoside reverse-transcriptase inhibitors has been recommended as a first-line regimen for ART-naïve HIV-1-infected patients in the latest Chinese Guidelines for Diagnosis and Treatment of HIV/AIDS.Objective: To determine the prevalence of INSTI-related mutations among ART-naïve HIV-1-infected adults in Guangdong, China, in 2018.Methods: The entire integrase gene was amplified from blood plasma. Demographic and epidemiological information was collected. INSTI mutations and antiretroviral susceptibility were interpreted using the Stanford University HIV Drug Resistance Database HIVdb program.Results: Of 927 samples, 827 integrase sequences were successfully obtained. Among them, no major resistance mutations to INSTIs were identified, and four accessory mutations, including T97A (0.12%, 1/827), A128T (0.24%, 2/827), E157Q (0.85%, 7/827), and G163R (0.24%, 2/827), were found in twelve individuals. Two patient samples contained the G163R mutation conferring low-level resistance to elvitegravir and raltegravir.Conclusion: The overall prevalence of INSTI mutations remains low. Drug resistance mutation testing for the detection of INSTI drug resistance mutations in HIV treatment-naïve patients should be considered due to the circulation of polymorphisms contributing to INSTI resistance and the expected increasing use of this class of drugs.Keywords: HIV-1, integrase inhibitor, drug resistance mutation, Guangdong |
| first_indexed | 2024-12-19T13:29:09Z |
| format | Article |
| id | doaj.art-0fd15ef078654342ae856589dc84ebd1 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-19T13:29:09Z |
| publishDate | 2020-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-0fd15ef078654342ae856589dc84ebd12022-12-21T20:19:28ZengDove Medical PressInfection and Drug Resistance1178-69732020-12-01Volume 134389439460130Absence of Integrase Inhibitor-Associated Resistance Among Antiretroviral Therapy-Naïve HIV-1-Infected Adults in Guangdong Province, China, in 2018Lan YLi LChen WDeng XLi JFan QCai XCai WHu FYun Lan,1,* Linghua Li,2,* Weilie Chen,1,* Xizi Deng,1 Junbin Li,2 Qinghong Fan,1 Xiaoli Cai,1 Weiping Cai,2 Fengyu Hu1 1Institute of Infectious Disease, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Infectious Disease Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weiping CaiInfectious Disease Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, 627 Dongfeng East Road, Yuexiu District, Guangzhou 510030, People’s Republic of ChinaTel +86-20-83710825Email gz8hcwp@126.comFengyu HuInstitute of Infectious Disease, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, 627 Dongfeng East Road, Yuexiu District, Guangzhou 510030, People’s Republic of ChinaTel +86-20-83710851Email gz8hhfy@126.comBackground: Antiretroviral therapy (ART) containing an integrase strand transfer inhibitor (INSTI) plus two nucleoside reverse-transcriptase inhibitors has been recommended as a first-line regimen for ART-naïve HIV-1-infected patients in the latest Chinese Guidelines for Diagnosis and Treatment of HIV/AIDS.Objective: To determine the prevalence of INSTI-related mutations among ART-naïve HIV-1-infected adults in Guangdong, China, in 2018.Methods: The entire integrase gene was amplified from blood plasma. Demographic and epidemiological information was collected. INSTI mutations and antiretroviral susceptibility were interpreted using the Stanford University HIV Drug Resistance Database HIVdb program.Results: Of 927 samples, 827 integrase sequences were successfully obtained. Among them, no major resistance mutations to INSTIs were identified, and four accessory mutations, including T97A (0.12%, 1/827), A128T (0.24%, 2/827), E157Q (0.85%, 7/827), and G163R (0.24%, 2/827), were found in twelve individuals. Two patient samples contained the G163R mutation conferring low-level resistance to elvitegravir and raltegravir.Conclusion: The overall prevalence of INSTI mutations remains low. Drug resistance mutation testing for the detection of INSTI drug resistance mutations in HIV treatment-naïve patients should be considered due to the circulation of polymorphisms contributing to INSTI resistance and the expected increasing use of this class of drugs.Keywords: HIV-1, integrase inhibitor, drug resistance mutation, Guangdonghttps://www.dovepress.com/absence-of-integrase-inhibitor-associated-resistance-among-antiretrovi-peer-reviewed-article-IDRhiv-1integrase inhibitordrug resistance mutationguangdong |
| spellingShingle | Lan Y Li L Chen W Deng X Li J Fan Q Cai X Cai W Hu F Absence of Integrase Inhibitor-Associated Resistance Among Antiretroviral Therapy-Naïve HIV-1-Infected Adults in Guangdong Province, China, in 2018 Infection and Drug Resistance hiv-1 integrase inhibitor drug resistance mutation guangdong |
| title | Absence of Integrase Inhibitor-Associated Resistance Among Antiretroviral Therapy-Naïve HIV-1-Infected Adults in Guangdong Province, China, in 2018 |
| title_full | Absence of Integrase Inhibitor-Associated Resistance Among Antiretroviral Therapy-Naïve HIV-1-Infected Adults in Guangdong Province, China, in 2018 |
| title_fullStr | Absence of Integrase Inhibitor-Associated Resistance Among Antiretroviral Therapy-Naïve HIV-1-Infected Adults in Guangdong Province, China, in 2018 |
| title_full_unstemmed | Absence of Integrase Inhibitor-Associated Resistance Among Antiretroviral Therapy-Naïve HIV-1-Infected Adults in Guangdong Province, China, in 2018 |
| title_short | Absence of Integrase Inhibitor-Associated Resistance Among Antiretroviral Therapy-Naïve HIV-1-Infected Adults in Guangdong Province, China, in 2018 |
| title_sort | absence of integrase inhibitor associated resistance among antiretroviral therapy na iuml ve hiv 1 infected adults in guangdong province china in 2018 |
| topic | hiv-1 integrase inhibitor drug resistance mutation guangdong |
| url | https://www.dovepress.com/absence-of-integrase-inhibitor-associated-resistance-among-antiretrovi-peer-reviewed-article-IDR |
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