Multi-approach metabolomics analysis and artificial simplified phytocomplexes reveal cultivar-dependent synergy between polyphenols and ascorbic acid in fruits of the sweet cherry (Prunus avium L.).
Fruits of the sweet cherry (Prunus avium L.) accumulate a range of antioxidants that can help to prevent cardiovascular disease, inflammation and cancer. We tested the in vitro antioxidant activity of 18 sweet cherry cultivars collected from 12 farms in the protected geographical indication region o...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5521804?pdf=render |
| _version_ | 1811237349274681344 |
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| author | Mauro Commisso Martino Bianconi Flavia Di Carlo Stefania Poletti Alessandra Bulgarini Francesca Munari Stefano Negri Matteo Stocchero Stefania Ceoldo Linda Avesani Michael Assfalg Gianni Zoccatelli Flavia Guzzo |
| author_facet | Mauro Commisso Martino Bianconi Flavia Di Carlo Stefania Poletti Alessandra Bulgarini Francesca Munari Stefano Negri Matteo Stocchero Stefania Ceoldo Linda Avesani Michael Assfalg Gianni Zoccatelli Flavia Guzzo |
| author_sort | Mauro Commisso |
| collection | DOAJ |
| description | Fruits of the sweet cherry (Prunus avium L.) accumulate a range of antioxidants that can help to prevent cardiovascular disease, inflammation and cancer. We tested the in vitro antioxidant activity of 18 sweet cherry cultivars collected from 12 farms in the protected geographical indication region of Marostica (Vicenza, Italy) during two growing seasons. Multiple targeted and untargeted metabolomics approaches (NMR, LC-MS, HPLC-DAD, HPLC-UV) as well as artificial simplified phytocomplexes representing the cultivars Sandra Tardiva, Sandra and Grace Star were then used to determine whether the total antioxidant activity reflected the additive effects of each compound or resulted from synergistic interactions. We found that the composition of each cultivar depended more on genetic variability than environmental factors. Furthermore, phenolic compounds were the principal source of antioxidant activity and experiments with artificial simplified phytocomplexes indicated strong synergy between the anthocyanins and quercetins/ascorbic acid specifically in the cultivar Sandra Tardiva. Our data therefore indicate that the total antioxidant activity of sweet cherry fruits may originate from cultivar-dependent interactions among different classes of metabolite. |
| first_indexed | 2024-04-12T12:22:54Z |
| format | Article |
| id | doaj.art-0fd1eaa37c3b43beb4f02ea82ffef987 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T12:22:54Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0fd1eaa37c3b43beb4f02ea82ffef9872022-12-22T03:33:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01127e018088910.1371/journal.pone.0180889Multi-approach metabolomics analysis and artificial simplified phytocomplexes reveal cultivar-dependent synergy between polyphenols and ascorbic acid in fruits of the sweet cherry (Prunus avium L.).Mauro CommissoMartino BianconiFlavia Di CarloStefania PolettiAlessandra BulgariniFrancesca MunariStefano NegriMatteo StoccheroStefania CeoldoLinda AvesaniMichael AssfalgGianni ZoccatelliFlavia GuzzoFruits of the sweet cherry (Prunus avium L.) accumulate a range of antioxidants that can help to prevent cardiovascular disease, inflammation and cancer. We tested the in vitro antioxidant activity of 18 sweet cherry cultivars collected from 12 farms in the protected geographical indication region of Marostica (Vicenza, Italy) during two growing seasons. Multiple targeted and untargeted metabolomics approaches (NMR, LC-MS, HPLC-DAD, HPLC-UV) as well as artificial simplified phytocomplexes representing the cultivars Sandra Tardiva, Sandra and Grace Star were then used to determine whether the total antioxidant activity reflected the additive effects of each compound or resulted from synergistic interactions. We found that the composition of each cultivar depended more on genetic variability than environmental factors. Furthermore, phenolic compounds were the principal source of antioxidant activity and experiments with artificial simplified phytocomplexes indicated strong synergy between the anthocyanins and quercetins/ascorbic acid specifically in the cultivar Sandra Tardiva. Our data therefore indicate that the total antioxidant activity of sweet cherry fruits may originate from cultivar-dependent interactions among different classes of metabolite.http://europepmc.org/articles/PMC5521804?pdf=render |
| spellingShingle | Mauro Commisso Martino Bianconi Flavia Di Carlo Stefania Poletti Alessandra Bulgarini Francesca Munari Stefano Negri Matteo Stocchero Stefania Ceoldo Linda Avesani Michael Assfalg Gianni Zoccatelli Flavia Guzzo Multi-approach metabolomics analysis and artificial simplified phytocomplexes reveal cultivar-dependent synergy between polyphenols and ascorbic acid in fruits of the sweet cherry (Prunus avium L.). PLoS ONE |
| title | Multi-approach metabolomics analysis and artificial simplified phytocomplexes reveal cultivar-dependent synergy between polyphenols and ascorbic acid in fruits of the sweet cherry (Prunus avium L.). |
| title_full | Multi-approach metabolomics analysis and artificial simplified phytocomplexes reveal cultivar-dependent synergy between polyphenols and ascorbic acid in fruits of the sweet cherry (Prunus avium L.). |
| title_fullStr | Multi-approach metabolomics analysis and artificial simplified phytocomplexes reveal cultivar-dependent synergy between polyphenols and ascorbic acid in fruits of the sweet cherry (Prunus avium L.). |
| title_full_unstemmed | Multi-approach metabolomics analysis and artificial simplified phytocomplexes reveal cultivar-dependent synergy between polyphenols and ascorbic acid in fruits of the sweet cherry (Prunus avium L.). |
| title_short | Multi-approach metabolomics analysis and artificial simplified phytocomplexes reveal cultivar-dependent synergy between polyphenols and ascorbic acid in fruits of the sweet cherry (Prunus avium L.). |
| title_sort | multi approach metabolomics analysis and artificial simplified phytocomplexes reveal cultivar dependent synergy between polyphenols and ascorbic acid in fruits of the sweet cherry prunus avium l |
| url | http://europepmc.org/articles/PMC5521804?pdf=render |
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