The correlation between fatty liver disease and chronic kidney disease
Background/purpose: The impact of non-alcoholic fatty liver disease (NAFLD) on the prevalence of chronic kidney disease (CKD) is not fully elucidated. We aimed to assess the correlation between NAFLD and CKD in a large population study. Methods: We included consecutive subjects who had received heal...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Journal of the Formosan Medical Association |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664618305916 |
| _version_ | 1811310827511218176 |
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| author | Po-Chun Chen Wei-Yu Kao Yuan-Lung Cheng Yuan-Jen Wang Ming-Chih Hou Jaw-Ching Wu Chien-Wei Su |
| author_facet | Po-Chun Chen Wei-Yu Kao Yuan-Lung Cheng Yuan-Jen Wang Ming-Chih Hou Jaw-Ching Wu Chien-Wei Su |
| author_sort | Po-Chun Chen |
| collection | DOAJ |
| description | Background/purpose: The impact of non-alcoholic fatty liver disease (NAFLD) on the prevalence of chronic kidney disease (CKD) is not fully elucidated. We aimed to assess the correlation between NAFLD and CKD in a large population study. Methods: We included consecutive subjects who had received health check-up service at Taipei Veterans General Hospital from 2002 to 2009. NAFLD was diagnosed with abdominal ultrasound, and advanced liver fibrosis was determined with NAFLD fibrosis score (NAFLD-FS). CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2. Results: Among the 29,797 subjects enrolled in this study, NAFLD and CKD were diagnosed in 44.5% and 20.2% of the population, respectively. Subjects with NAFLD had a higher proportion of CKD compared to those without NAFLD (24.1% vs. 17.1%, p < 0.001). However, NAFLD was not related to CKD with an odds ratio (OR) of 1.015 (95% confidence interval [CI] 0.954–1.081, p = 0.630) after multivariate analyses. Nevertheless, further analyses revealed that among patients with NAFLD, those with advanced fibrosis were more likely to have CKD after adjusting for confounding factors (OR 2.284, 95% CI 1.513–3.448, p < 0.001). Conclusion: NAFLD per se was not a risk factor for CKD, but NAFLD patients with advanced fibrosis faced a higher possibility of CKD. Hence, patients with NAFLD and advanced fibrosis should be screened for CKD and prompted to receive treatment if the diagnosis was made. Keywords: Non-alcoholic fatty liver disease, Kidney diseases, Liver fibrosis |
| first_indexed | 2024-04-13T10:05:56Z |
| format | Article |
| id | doaj.art-0fd212aacf5e4402aed99d1355725995 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-04-13T10:05:56Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-0fd212aacf5e4402aed99d13557259952022-12-22T02:51:05ZengElsevierJournal of the Formosan Medical Association0929-66462020-01-0111914250The correlation between fatty liver disease and chronic kidney diseasePo-Chun Chen0Wei-Yu Kao1Yuan-Lung Cheng2Yuan-Jen Wang3Ming-Chih Hou4Jaw-Ching Wu5Chien-Wei Su6Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, TaiwanFaculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, TaiwanFaculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Gastroenterology, Department of Medicine, Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan; Corresponding author. Division of Gastroenterology, Department of Medicine, Taipei Municipal Gan-Dau Hospital, No. 12, Ln. 225, Zhixing Rd., Taipei, Taiwan. Fax: +886 2 2858 2266.Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Healthcare and Services, Department of Medicine, Taipei Veterans General Hospital, Taipei, TaiwanDivision of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, TaiwanInstitute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Medical Research, Taipei Veterans General Hospital, Taipei, TaiwanDivision of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Corresponding author. Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, No.201 Shih-Pai Road, Section 2, Taipei, 112, Taiwan. Fax: +886 2 2873 9318.Background/purpose: The impact of non-alcoholic fatty liver disease (NAFLD) on the prevalence of chronic kidney disease (CKD) is not fully elucidated. We aimed to assess the correlation between NAFLD and CKD in a large population study. Methods: We included consecutive subjects who had received health check-up service at Taipei Veterans General Hospital from 2002 to 2009. NAFLD was diagnosed with abdominal ultrasound, and advanced liver fibrosis was determined with NAFLD fibrosis score (NAFLD-FS). CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2. Results: Among the 29,797 subjects enrolled in this study, NAFLD and CKD were diagnosed in 44.5% and 20.2% of the population, respectively. Subjects with NAFLD had a higher proportion of CKD compared to those without NAFLD (24.1% vs. 17.1%, p < 0.001). However, NAFLD was not related to CKD with an odds ratio (OR) of 1.015 (95% confidence interval [CI] 0.954–1.081, p = 0.630) after multivariate analyses. Nevertheless, further analyses revealed that among patients with NAFLD, those with advanced fibrosis were more likely to have CKD after adjusting for confounding factors (OR 2.284, 95% CI 1.513–3.448, p < 0.001). Conclusion: NAFLD per se was not a risk factor for CKD, but NAFLD patients with advanced fibrosis faced a higher possibility of CKD. Hence, patients with NAFLD and advanced fibrosis should be screened for CKD and prompted to receive treatment if the diagnosis was made. Keywords: Non-alcoholic fatty liver disease, Kidney diseases, Liver fibrosishttp://www.sciencedirect.com/science/article/pii/S0929664618305916 |
| spellingShingle | Po-Chun Chen Wei-Yu Kao Yuan-Lung Cheng Yuan-Jen Wang Ming-Chih Hou Jaw-Ching Wu Chien-Wei Su The correlation between fatty liver disease and chronic kidney disease Journal of the Formosan Medical Association |
| title | The correlation between fatty liver disease and chronic kidney disease |
| title_full | The correlation between fatty liver disease and chronic kidney disease |
| title_fullStr | The correlation between fatty liver disease and chronic kidney disease |
| title_full_unstemmed | The correlation between fatty liver disease and chronic kidney disease |
| title_short | The correlation between fatty liver disease and chronic kidney disease |
| title_sort | correlation between fatty liver disease and chronic kidney disease |
| url | http://www.sciencedirect.com/science/article/pii/S0929664618305916 |
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