Oxidized Low-Density Lipoprotein and its Atherogenic Potential
The emergence of oxidized low-density lipoprotein (OxLDL) is crucial for the progression of cardiovascular diseases (CVD) linked to atherosclerosis. OxLDL stimulates endothelial activation and smooth muscle proliferation and has an atherosclerotic-promoting effect. The measurement of OxLDL correlate...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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International Medical Research and Development Corporation
2022-09-01
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| Series: | International Journal of Biomedicine |
| Subjects: | |
| Online Access: | http://www.ijbm.org/articles/i47/ijbm_12(3)_ra2.pdf |
| _version_ | 1818066633310076928 |
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| author | Harish Rangareddy Shashidhar Kurpad Nagaraj Soumya Narayanaswamy |
| author_facet | Harish Rangareddy Shashidhar Kurpad Nagaraj Soumya Narayanaswamy |
| author_sort | Harish Rangareddy |
| collection | DOAJ |
| description | The emergence of oxidized low-density lipoprotein (OxLDL) is crucial for the progression of cardiovascular diseases (CVD) linked to atherosclerosis. OxLDL stimulates endothelial activation and smooth muscle proliferation and has an atherosclerotic-promoting effect. The measurement of OxLDL correlates with the presence of CVD and may be a prognostic marker for future health outcomes. Circulating OxLDLs can be used as biomarkers since their levels rise in patients with advanced atherosclerosis. Immunological methods have proven to be very useful methodologies. Anti-OxLDL monoclonal antibodies have been developed that bind strongly to OxLDL and are used in ELISA for OxLDL measurements. Routine inclusion of OxLDL estimation in an at-risk population can help the clinicians understand the disease initiation and progression and improve early intervention and management. |
| first_indexed | 2024-12-10T15:10:53Z |
| format | Article |
| id | doaj.art-0fd2212371f848a4a827a7687d102784 |
| institution | Directory Open Access Journal |
| issn | 2158-0510 2158-0529 |
| language | English |
| last_indexed | 2024-12-10T15:10:53Z |
| publishDate | 2022-09-01 |
| publisher | International Medical Research and Development Corporation |
| record_format | Article |
| series | International Journal of Biomedicine |
| spelling | doaj.art-0fd2212371f848a4a827a7687d1027842022-12-22T01:43:55ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292022-09-0112333934310.21103/Article12(3)_RA2Oxidized Low-Density Lipoprotein and its Atherogenic PotentialHarish Rangareddy0Shashidhar Kurpad Nagaraj1Soumya Narayanaswamy2Department of Biochemistry, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, IndiaDepartment of Biochemistry, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, IndiaDepartment of Biochemistry, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, IndiaThe emergence of oxidized low-density lipoprotein (OxLDL) is crucial for the progression of cardiovascular diseases (CVD) linked to atherosclerosis. OxLDL stimulates endothelial activation and smooth muscle proliferation and has an atherosclerotic-promoting effect. The measurement of OxLDL correlates with the presence of CVD and may be a prognostic marker for future health outcomes. Circulating OxLDLs can be used as biomarkers since their levels rise in patients with advanced atherosclerosis. Immunological methods have proven to be very useful methodologies. Anti-OxLDL monoclonal antibodies have been developed that bind strongly to OxLDL and are used in ELISA for OxLDL measurements. Routine inclusion of OxLDL estimation in an at-risk population can help the clinicians understand the disease initiation and progression and improve early intervention and management.http://www.ijbm.org/articles/i47/ijbm_12(3)_ra2.pdfoxidized ldloxidative stressatherosclerosiselisa |
| spellingShingle | Harish Rangareddy Shashidhar Kurpad Nagaraj Soumya Narayanaswamy Oxidized Low-Density Lipoprotein and its Atherogenic Potential International Journal of Biomedicine oxidized ldl oxidative stress atherosclerosis elisa |
| title | Oxidized Low-Density Lipoprotein and its Atherogenic Potential |
| title_full | Oxidized Low-Density Lipoprotein and its Atherogenic Potential |
| title_fullStr | Oxidized Low-Density Lipoprotein and its Atherogenic Potential |
| title_full_unstemmed | Oxidized Low-Density Lipoprotein and its Atherogenic Potential |
| title_short | Oxidized Low-Density Lipoprotein and its Atherogenic Potential |
| title_sort | oxidized low density lipoprotein and its atherogenic potential |
| topic | oxidized ldl oxidative stress atherosclerosis elisa |
| url | http://www.ijbm.org/articles/i47/ijbm_12(3)_ra2.pdf |
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