Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI
Abstract Background The current study investigated the performance of intravoxel incoherent motion diffusion (IVIM) technology in monitoring early renal injury in streptozotocin rats. Methods Forty-eight Sprague-Dawley (SD) rats were divided into a control group and a diabetic mellitus (DM) group. S...
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| Language: | English |
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BMC
2021-09-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-021-02530-8 |
| _version_ | 1818399198587912192 |
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| author | You-Zhen Feng Xiao-Qiao Chen Zhong-Yuan Cheng Qi-Ting Lin Ping-Kang Chen Ding-Kun Si-Tu Rui Cao Long Qian Baoli Heng Xiang-Ran Cai |
| author_facet | You-Zhen Feng Xiao-Qiao Chen Zhong-Yuan Cheng Qi-Ting Lin Ping-Kang Chen Ding-Kun Si-Tu Rui Cao Long Qian Baoli Heng Xiang-Ran Cai |
| author_sort | You-Zhen Feng |
| collection | DOAJ |
| description | Abstract Background The current study investigated the performance of intravoxel incoherent motion diffusion (IVIM) technology in monitoring early renal injury in streptozotocin rats. Methods Forty-eight Sprague-Dawley (SD) rats were divided into a control group and a diabetic mellitus (DM) group. Six rats in each group were randomly selected for MR scans at four different time points (0, 4, 8, and 12 weeks). The IVIM-derived parameters (D, D*, f and ADC values) of the renal cortex (CO), outer and inner stripe of the outer medulla (OS, IS), and internal medulla (IM) were acquired. Changes in each IVIM-derived parameter over time were analyzed, and differences between the two groups at each point were assessed. The associations between the IVIM parameters and IV collagen expression, urine volume (UV), blood urea nitrogen (BUN), and serum creatinine (Scr) were investigated. Results The D and D* values of CO and the ADC values of CO, OS, IS and IM displayed significantly different trends between the two groups over time (P<0.05). In addition, significant correlations were discovered between the D* value of CO and UV and BUN (r=0.527, P=0.033; r=0.617, P=0.005), between the ADC value of IM and BUN (r=0.557, P=0.019) and between the f value of IM and BUN (r=0.527, P=0.033). No correlation was found between IVIM parameters and IV collagen expression and Scr. Conclusions IVIM is a potential sensitive and noninvasive technology for the simultaneous assessment of early renal cortical and medullary injuries induced by diabetes. |
| first_indexed | 2024-12-14T07:16:52Z |
| format | Article |
| id | doaj.art-0fd57017d10d4b37b2cc2e19e5398bc9 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-14T07:16:52Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-0fd57017d10d4b37b2cc2e19e5398bc92022-12-21T23:11:41ZengBMCBMC Nephrology1471-23692021-09-0122111210.1186/s12882-021-02530-8Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRIYou-Zhen Feng0Xiao-Qiao Chen1Zhong-Yuan Cheng2Qi-Ting Lin3Ping-Kang Chen4Ding-Kun Si-Tu5Rui Cao6Long Qian7Baoli Heng8Xiang-Ran Cai9Medical Imaging Center, Jinan University First Affiliated HospitalMedical Imaging Center, The Eighth Affiliated Hospital of Sun Yat-Sen UniversityMedical Imaging Center, Jinan University First Affiliated HospitalMedical Imaging Center, Jinan University First Affiliated HospitalMedical Imaging Center, Jinan University First Affiliated HospitalMedical Imaging Center, Jinan University First Affiliated HospitalNephrology Department, Jinan University First Affiliated HospitalGE HealthcareYingde Base, Institute of Kidney Surgery, Jinan UniversityMedical Imaging Center, Jinan University First Affiliated HospitalAbstract Background The current study investigated the performance of intravoxel incoherent motion diffusion (IVIM) technology in monitoring early renal injury in streptozotocin rats. Methods Forty-eight Sprague-Dawley (SD) rats were divided into a control group and a diabetic mellitus (DM) group. Six rats in each group were randomly selected for MR scans at four different time points (0, 4, 8, and 12 weeks). The IVIM-derived parameters (D, D*, f and ADC values) of the renal cortex (CO), outer and inner stripe of the outer medulla (OS, IS), and internal medulla (IM) were acquired. Changes in each IVIM-derived parameter over time were analyzed, and differences between the two groups at each point were assessed. The associations between the IVIM parameters and IV collagen expression, urine volume (UV), blood urea nitrogen (BUN), and serum creatinine (Scr) were investigated. Results The D and D* values of CO and the ADC values of CO, OS, IS and IM displayed significantly different trends between the two groups over time (P<0.05). In addition, significant correlations were discovered between the D* value of CO and UV and BUN (r=0.527, P=0.033; r=0.617, P=0.005), between the ADC value of IM and BUN (r=0.557, P=0.019) and between the f value of IM and BUN (r=0.527, P=0.033). No correlation was found between IVIM parameters and IV collagen expression and Scr. Conclusions IVIM is a potential sensitive and noninvasive technology for the simultaneous assessment of early renal cortical and medullary injuries induced by diabetes.https://doi.org/10.1186/s12882-021-02530-8Early diabetic nephropathyNoninvasiveIntravoxel incoherent motion diffusionPathological correlationStreptozotocin |
| spellingShingle | You-Zhen Feng Xiao-Qiao Chen Zhong-Yuan Cheng Qi-Ting Lin Ping-Kang Chen Ding-Kun Si-Tu Rui Cao Long Qian Baoli Heng Xiang-Ran Cai Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI BMC Nephrology Early diabetic nephropathy Noninvasive Intravoxel incoherent motion diffusion Pathological correlation Streptozotocin |
| title | Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI |
| title_full | Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI |
| title_fullStr | Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI |
| title_full_unstemmed | Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI |
| title_short | Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI |
| title_sort | non invasive investigation of early kidney damage in streptozotocin induced diabetic rats by intravoxel incoherent motion diffusion weighted ivim mri |
| topic | Early diabetic nephropathy Noninvasive Intravoxel incoherent motion diffusion Pathological correlation Streptozotocin |
| url | https://doi.org/10.1186/s12882-021-02530-8 |
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