Long-term survival, toxicities, and the role of chrono-chemotherapy with different infusion rates in locally advanced nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy: a retrospective study with a 5-year follow-up
PurposeThis study aimed to evaluate 5-year outcomes and the late toxicity profile of chrono-chemotherapy with different infusion rates in patients with locally advanced nasopharyngeal carcinoma (NPC).Methods and materialsOur retrospective analysis included 70 patients with locally advanced NPC stage...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1371878/full |
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| author | Lina Liu Lina Liu Lina Liu Xunyan Luo Weili Wu Weili Wu Yuanyuan Li Yuanyuan Li Yuanyuan Li Jinhua Long Jinhua Long Xiuling Luo Xiuling Luo Xiaoxiao Chen Xiuyun Gong Chaofen Zhao Chaofen Zhao Qianyong He Qianyong He Qianyong He Zhuoling Li Zhuoling Li Zhuoling Li Kai Shang Yue Chen Xu Xinyu Feng Jin Feng Jin Feng Jin |
| author_facet | Lina Liu Lina Liu Lina Liu Xunyan Luo Weili Wu Weili Wu Yuanyuan Li Yuanyuan Li Yuanyuan Li Jinhua Long Jinhua Long Xiuling Luo Xiuling Luo Xiaoxiao Chen Xiuyun Gong Chaofen Zhao Chaofen Zhao Qianyong He Qianyong He Qianyong He Zhuoling Li Zhuoling Li Zhuoling Li Kai Shang Yue Chen Xu Xinyu Feng Jin Feng Jin Feng Jin |
| author_sort | Lina Liu |
| collection | DOAJ |
| description | PurposeThis study aimed to evaluate 5-year outcomes and the late toxicity profile of chrono-chemotherapy with different infusion rates in patients with locally advanced nasopharyngeal carcinoma (NPC).Methods and materialsOur retrospective analysis included 70 patients with locally advanced NPC stages III and IVB (according to the 2010 American Joint Committee on Cancer staging system). Patients were treated with two cycles of induction chemotherapy (IC) before concurrent chemoradiotherapy (CCRT) at Guizhou Cancer Hospital. The IC with docetaxel, cisplatin (DDP) and fluorouracil regimen. Patients were divided into two groups during CCRT. Using a “MELODIE” multi-channel programmed pump, DDP (100 mg/m2) was administered for 12 hours from 10:00 am to 10:00 pm and repeated every 3 weeks for 2-3 cycles. DDP was administered at the peak period of 4:00 pm in the sinusoidal chrono-modulated infusion group (Arm A, n=35). The patients in Arm B received a constant rate of infusion. Both arms received radiotherapy through the same technique and dose fraction. The long-term survival and disease progression were observed.ResultsAfter a median follow-up of 82.8 months, the 5-year progression-free survival rate was 81.3% in Arm A and 79.6% in Arm B (P = 0.85). The 5-year overall survival rate was not significantly different between Arm A and Arm B (79.6% vs 85.3%, P = 0.79). The 5-year distant metastasis-free survival rate was 83.6% in Arm A and 84.6% in Arm B (P = 0.75). The 5-year local recurrence-free survival rate was 88.2% in Arm A and 85.3% in Arm B (P = 0.16). There were no late toxicities of grade 3-4 in either group. Both groups had grade 1-2 late toxicities. Dry mouth was the most common late toxic side effect, followed by hearing loss and difficulty in swallowing. There was no statistically significant difference between Arm A and Arm B in terms of side effects.ConclusionLong-term analysis confirmed that in CCRT, cisplatin administration with sinusoidal chrono-modulated infusion was not superior to the constant infusion rate in terms of long-term toxicity and prognosis. |
| first_indexed | 2024-04-24T20:27:39Z |
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| language | English |
| last_indexed | 2024-04-24T20:27:39Z |
| publishDate | 2024-03-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-0fd57c202a184f1faaeba1cd46be80f82024-03-22T04:55:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-03-011410.3389/fonc.2024.13718781371878Long-term survival, toxicities, and the role of chrono-chemotherapy with different infusion rates in locally advanced nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy: a retrospective study with a 5-year follow-upLina Liu0Lina Liu1Lina Liu2Xunyan Luo3Weili Wu4Weili Wu5Yuanyuan Li6Yuanyuan Li7Yuanyuan Li8Jinhua Long9Jinhua Long10Xiuling Luo11Xiuling Luo12Xiaoxiao Chen13Xiuyun Gong14Chaofen Zhao15Chaofen Zhao16Qianyong He17Qianyong He18Qianyong He19Zhuoling Li20Zhuoling Li21Zhuoling Li22Kai Shang23Yue Chen24Xu Xinyu25Feng Jin26Feng Jin27Feng Jin28Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaPurposeThis study aimed to evaluate 5-year outcomes and the late toxicity profile of chrono-chemotherapy with different infusion rates in patients with locally advanced nasopharyngeal carcinoma (NPC).Methods and materialsOur retrospective analysis included 70 patients with locally advanced NPC stages III and IVB (according to the 2010 American Joint Committee on Cancer staging system). Patients were treated with two cycles of induction chemotherapy (IC) before concurrent chemoradiotherapy (CCRT) at Guizhou Cancer Hospital. The IC with docetaxel, cisplatin (DDP) and fluorouracil regimen. Patients were divided into two groups during CCRT. Using a “MELODIE” multi-channel programmed pump, DDP (100 mg/m2) was administered for 12 hours from 10:00 am to 10:00 pm and repeated every 3 weeks for 2-3 cycles. DDP was administered at the peak period of 4:00 pm in the sinusoidal chrono-modulated infusion group (Arm A, n=35). The patients in Arm B received a constant rate of infusion. Both arms received radiotherapy through the same technique and dose fraction. The long-term survival and disease progression were observed.ResultsAfter a median follow-up of 82.8 months, the 5-year progression-free survival rate was 81.3% in Arm A and 79.6% in Arm B (P = 0.85). The 5-year overall survival rate was not significantly different between Arm A and Arm B (79.6% vs 85.3%, P = 0.79). The 5-year distant metastasis-free survival rate was 83.6% in Arm A and 84.6% in Arm B (P = 0.75). The 5-year local recurrence-free survival rate was 88.2% in Arm A and 85.3% in Arm B (P = 0.16). There were no late toxicities of grade 3-4 in either group. Both groups had grade 1-2 late toxicities. Dry mouth was the most common late toxic side effect, followed by hearing loss and difficulty in swallowing. There was no statistically significant difference between Arm A and Arm B in terms of side effects.ConclusionLong-term analysis confirmed that in CCRT, cisplatin administration with sinusoidal chrono-modulated infusion was not superior to the constant infusion rate in terms of long-term toxicity and prognosis.https://www.frontiersin.org/articles/10.3389/fonc.2024.1371878/fullnasopharyngeal carcinomachrono-chemotherapyradiotherapyintensity-modulated radiotherapylate toxicity |
| spellingShingle | Lina Liu Lina Liu Lina Liu Xunyan Luo Weili Wu Weili Wu Yuanyuan Li Yuanyuan Li Yuanyuan Li Jinhua Long Jinhua Long Xiuling Luo Xiuling Luo Xiaoxiao Chen Xiuyun Gong Chaofen Zhao Chaofen Zhao Qianyong He Qianyong He Qianyong He Zhuoling Li Zhuoling Li Zhuoling Li Kai Shang Yue Chen Xu Xinyu Feng Jin Feng Jin Feng Jin Long-term survival, toxicities, and the role of chrono-chemotherapy with different infusion rates in locally advanced nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy: a retrospective study with a 5-year follow-up Frontiers in Oncology nasopharyngeal carcinoma chrono-chemotherapy radiotherapy intensity-modulated radiotherapy late toxicity |
| title | Long-term survival, toxicities, and the role of chrono-chemotherapy with different infusion rates in locally advanced nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy: a retrospective study with a 5-year follow-up |
| title_full | Long-term survival, toxicities, and the role of chrono-chemotherapy with different infusion rates in locally advanced nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy: a retrospective study with a 5-year follow-up |
| title_fullStr | Long-term survival, toxicities, and the role of chrono-chemotherapy with different infusion rates in locally advanced nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy: a retrospective study with a 5-year follow-up |
| title_full_unstemmed | Long-term survival, toxicities, and the role of chrono-chemotherapy with different infusion rates in locally advanced nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy: a retrospective study with a 5-year follow-up |
| title_short | Long-term survival, toxicities, and the role of chrono-chemotherapy with different infusion rates in locally advanced nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy: a retrospective study with a 5-year follow-up |
| title_sort | long term survival toxicities and the role of chrono chemotherapy with different infusion rates in locally advanced nasopharyngeal carcinoma patients treated with intensity modulated radiation therapy a retrospective study with a 5 year follow up |
| topic | nasopharyngeal carcinoma chrono-chemotherapy radiotherapy intensity-modulated radiotherapy late toxicity |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1371878/full |
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