Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome
Abstract Background Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports were inconsistent. Methods Two hundred s...
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BMC
2020-05-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12902-020-0538-1 |
| _version_ | 1818417414202720256 |
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| author | Sha Liu Wenjing Hu Yirui He Ling Li Hua Liu Lin Gao Gangyi Yang Xin Liao |
| author_facet | Sha Liu Wenjing Hu Yirui He Ling Li Hua Liu Lin Gao Gangyi Yang Xin Liao |
| author_sort | Sha Liu |
| collection | DOAJ |
| description | Abstract Background Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports were inconsistent. Methods Two hundred seven subjects were screened for PCOS according to the diagnostic guideline of the Rotterdam consensus criterion. Serum Fetuin-A levels were measured using an ELISA kit. An independent t-test or Nonparametric test was used to detect differences between PCOS and control groups. Spearman’s correlation analysis was used to examine the association of the serum Fetuin-A with other parameters. Results Our findings showed that circulating Fetuin-A concentration ranged from 196.6 to 418.2 μg/L for most women without PCOS (95%). Women with PCOS had higher circulating Fetuin-A levels than healthy women (437.9 ± 119.3 vs. 313.8 ± 60.5 μg/L; p < 0.01). Serum Fetuin-A was positively correlated with BMI, WHR, TG, TC, LDL-C, HOMA-IR, LH, T, and DHEA-S. Multivariate regression analysis showed that WHR, TG, HOMA-IR, and DHEA-S were independent predictors of the levels of circulating Fetuin-A. Binary logistic regression revealed that serum Fetuin-A was associated with the occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6 μg/L. Conclusion Blood Fetuin-A may be a useful biomarker for screening women for PCOS and IR. |
| first_indexed | 2024-12-14T12:06:24Z |
| format | Article |
| id | doaj.art-0fd6a8e1fb9742cdbaa53d88d9e8727c |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-14T12:06:24Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-0fd6a8e1fb9742cdbaa53d88d9e8727c2022-12-21T23:01:51ZengBMCBMC Endocrine Disorders1472-68232020-05-012011710.1186/s12902-020-0538-1Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndromeSha Liu0Wenjing Hu1Yirui He2Ling Li3Hua Liu4Lin Gao5Gangyi Yang6Xin Liao7Department of Endocrinology, the Affiliated Hospital, Zunyi Medical UniversityChongqing Prevention and Treatment Hospital for Occupational DiseasesDepartment of Endocrinology, the Second Affiliated Hospital, Chongqing Medical UniversityKey Laboratory of Diagnostic Medicine (Ministry of Education) and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical UniversityDepartment of Pediatrics, University of Mississippi Medical CenterDepartment of Endocrinology, the Affiliated Hospital, Zunyi Medical UniversityDepartment of Endocrinology, the Affiliated Hospital, Zunyi Medical UniversityDepartment of Endocrinology, the Affiliated Hospital, Zunyi Medical UniversityAbstract Background Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports were inconsistent. Methods Two hundred seven subjects were screened for PCOS according to the diagnostic guideline of the Rotterdam consensus criterion. Serum Fetuin-A levels were measured using an ELISA kit. An independent t-test or Nonparametric test was used to detect differences between PCOS and control groups. Spearman’s correlation analysis was used to examine the association of the serum Fetuin-A with other parameters. Results Our findings showed that circulating Fetuin-A concentration ranged from 196.6 to 418.2 μg/L for most women without PCOS (95%). Women with PCOS had higher circulating Fetuin-A levels than healthy women (437.9 ± 119.3 vs. 313.8 ± 60.5 μg/L; p < 0.01). Serum Fetuin-A was positively correlated with BMI, WHR, TG, TC, LDL-C, HOMA-IR, LH, T, and DHEA-S. Multivariate regression analysis showed that WHR, TG, HOMA-IR, and DHEA-S were independent predictors of the levels of circulating Fetuin-A. Binary logistic regression revealed that serum Fetuin-A was associated with the occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6 μg/L. Conclusion Blood Fetuin-A may be a useful biomarker for screening women for PCOS and IR.http://link.springer.com/article/10.1186/s12902-020-0538-1Fetuin-aPolycystic ovary syndromeInsulin resistance |
| spellingShingle | Sha Liu Wenjing Hu Yirui He Ling Li Hua Liu Lin Gao Gangyi Yang Xin Liao Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome BMC Endocrine Disorders Fetuin-a Polycystic ovary syndrome Insulin resistance |
| title | Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome |
| title_full | Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome |
| title_fullStr | Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome |
| title_full_unstemmed | Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome |
| title_short | Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome |
| title_sort | serum fetuin a levels are increased and associated with insulin resistance in women with polycystic ovary syndrome |
| topic | Fetuin-a Polycystic ovary syndrome Insulin resistance |
| url | http://link.springer.com/article/10.1186/s12902-020-0538-1 |
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